Diabetic ketoacidosis with mild hyperglycemia associated with the use of canagliflozin. Report of one case with type 1 diabetes

Indexación: Web of Science; Scopus; Scielo.Diabetic ketoacidosis with mild hyperglycemia is a major complication of sodium-glucose cotransporter 2 inhibitors. Although its use is not approved for patients with type 1 diabetes mellitus, the drug is often prescribed with the hope of optimizing metabolic control. We report a 20 years old female with hypo-thyroidism and type 1 diabetes consulting for vomiting and abdominal pain. The patient had used canagliflozin during the two previous months. Laboratory showed a blood glucose of 200 mg/dl, a severe metabolic acidosis (pH 7.1) and ketonemia. The patient was successfully treated in the intensive care unit.http://ref.scielo.org/65brd

The Nuclear Stellar Cluster in the Seyfert~1 Galaxy NGC 3227: High Angular Resolution NIR Imaging and Spectroscopy

NIR high angular resolution speckle imaging and imaging spectroscopy of the nuclear region (10'' ~ 840pc) of the Seyfert1 galaxy NGC3227 are presented. A nuclear stellar cluster is slightly resolved in the J and H band with increasing contribution to the NIR continuum from the K to the J band. The stellar absorption lines are extended compared to the neighboring continuum suggesting a cluster size of ~ 70pc FWHM. Analysis of those lines suggests that the stars are contributing about 65% (40%) of the total continuum emission in the H (K) band in a 3.6'' aperture. Population synthesis in conjunction with NIR spectral synthesis indicates an age of 25 to 50 Myr when red supergiants contribute most to the NIR light. This is supported by published optical data on the MgIb line and the CaII triplet. Although a higher age of ~ 0.5 Gyr where AGB stars dominate the NIR light can not be excluded, the observed parameters are at the limit of those expected for a cluster dominated by AGB stars. However, in either case the resolved stellar cluster contributes only about ~ 15 % of the total dynamical mass in the inner 300pc implying another much older stellar population. Pure constant star formation over the last 10 Gyr can be excluded. Therefore, at least two star formation/starburst events took place in the nucleus of NGC3227. Since such sequences in the nuclear star formation history are also observed in the nuclei of other galaxies a link between the activity of the star formation and the AGN itself seems likely.Comment: accepted for publication in the Astrophysical Journal, 46 pages, 15 figure

The Nature of LINERs

We present $J$-band ($1.15-1.35 \mu$m) spectroscopy of a sample of nine galaxies showing some degree of LINER activity (classical LINERs, weak-[O {\sc i}] LINERs and transition objects), together with $H$-band spectroscopy for some of them. A careful subtraction of the stellar continuum allows us to obtain reliable [Fe {\sc ii}]$1.2567 \mu$m/Pa$\beta$ line ratios. We conclude that different types of LINERs (i.e., photoionized by a stellar continuum or by an AGN) cannot be easily distinguished based solely on the [Fe {\sc ii}]$1.2567 \mu$m/Pa$\beta$ line ratio. The emission line properties of many LINERs can be explained in terms of an aging starburst. The optical line ratios of these LINERs are reproduced by a model with a metal-rich H {\sc ii} region component photoionized with a single stellar temperature $T_* = 38,000$K, plus a supernova remnant (SNR) component. The [Fe {\sc ii}] line is predominantly excited by shocks produced by SNRs in starbursts and starburst-dominated LINERs, while Pa$\beta$ tracks H {\sc ii} regions ionized by massive young stars. The contribution from SNRs to the overall emission line spectrum is constrained by the [Fe {\sc ii}]$1.2567 \mu$m/Pa$\beta$ line ratio. Although our models for aging starbursts are constrained only by these infrared lines, they consistently explain the optical spectra of the galaxies also. The LINER-starburst connection is tested by predicting the time dependence of the ratio of the ionizing luminosity ($L_{\rm ion}$) to the supernova rate (SNr), $L_{\rm ion}$/(SNr). We predict the relative number of starbursts to starburst-dominated LINERs (aging starbursts) and show that it is in approximate agreement with survey findings for nearby galaxies.Comment: Accepted in ApJ (19 pages, 8 figures, uses emulateapj.sty

Effect of Eu 3+

This work presents the structural, morphological, and luminescent characterization of pure SrTiO3 and SrTiO3:Eu3+ powders doped with different europium atomic concentrations from 3.0 to 7.0 a.t.%. Those phosphors were prepared by pressure-assisted combustion synthesis using titanium oxide as precursor and were subjected to postannealing at 1200°C. XRD measurements indicated that undoped and Eu3+ doped samples presented a single cubic crystalline phase and SEM images demonstrated that we have particles with sizes in the range of 0.2 µm–1.0 µm. Moreover, the size of the grains increases as the content of Eu3+ dopant increases. A strong red emission from Eu3+ ions was obtained by photoluminescence under excitation at 396 nm and confirmed by cathodoluminescence. All those results indicate that our red phosphors could be useful for potential applications in solid state lighting and field emission displays

IRAS 06562-0337, The Iron Clad Nebula: A New Young Star Cluster

IRAS 06562-0337 has been the recent subject of a classic debate: proto-planetary nebula or young stellar object? We present the first 2 micron image of IRAS 06562-0337, which reveals an extended diffuse nebula containing approximately 70 stars inside a 30 arcsec radius around a bright, possibly resolved, central object. The derived stellar luminosity function is consistent with that expected from a single coeval population, and the brightness of the nebulosity is consistent with the predicted flux of unresolved low-mass stars. The stars and nebulosity are spatially coincident with strong CO line emission. We therefore identify IRAS 06562-0337 as a new young star cluster embedded in its placental molecular cloud. The central object is likely a Herbig Be star, M approx 20 M_sun, which may be seen in reflection. We present medium resolution, high S/N, 1997 epoch optical spectra of the central object. Comparison with previously published spectra shows new evidence for time variable permitted and forbidden line emission, including SiII, FeII, [FeII], and [OI]. We suggest the origin is a dynamic stellar wind in the extended, stratified atmosphere of the massive central star in IRAS 06562-0337.Comment: 25 pages (4 figures) using aaspp4.sty. Accepted for publication in A

Artillery Shells over Circinus

The recently identified Circinus Galaxy is the nearest (about 4 Mpc) Seyfert 2 galaxy known and we now demonstrate to be one of the best laboratories for studying the effects of nuclear activity on the surrounding environment. Here we present new imaging Fabry-Perot observations of Circinus which confirm the existence of an ionization cone in this object but also show for the first time a complex of ionized filaments extending radially from the nucleus out to distances of 1 kpc. Arcs suggestive of bow shocks are observed at the terminus of some of these filamentary structures. Most spectacular of all, one of the structures appears to be a scaled-up version of a Herbig-Haro jet. The velocity field of the filaments confirms that they represent material expelled from the nucleus (possibly in the form of `bullets') or entrained in a wide-angle wind roughly aligned with the polar axis of the galaxy. The motions observed across the ionization cone are highly supersonic, so high-velocity shocks are likely to contribute to the ionization of the line emitting gas. However, it is not clear at present whether shock ionization dominates over photoionization by the Seyfert 2 nucleus. Extrapolation of the filaments to smaller radii comes to within 1 arcsec (about 20 pc) of the infrared nucleus, therefore suggesting a AGN or nuclear starburst origin to these features. The complex of radial filaments detected in the Circinus galaxy is unique among active galaxies. The frequency of such events is unknown since only a handful of galaxies have been observed at the sensitivity level of our present observations. The event in the Circinus galaxy may represent a relatively common evolutionary phase in the lives of gas-rich active galaxies during which the dusty cocoon surrounding the nucleus is expelled by the action of jet or wind phenomena.Comment: 22 pages including 5 figures, Latex, requires aasms4.sty. To appear in ApJ Letters 479 (1997

Quadratic Curvature Gravity with Second Order Trace and Massive Gravity Models in Three Dimensions

The quadratic curvature lagrangians having metric field equations with second order trace are constructed relative to an orthonormal coframe. In $n>4$ dimensions, pure quadratic curvature lagrangian having second order trace constructed contains three free parameters in the most general case. The fourth order field equations of some of these models, in arbitrary dimensions, are cast in a particular form using the Schouten tensor. As a consequence, the field equations for the New massive gravity theory are related to those of the Topologically massive gravity. In particular, the conditions under which the latter is "square root" of the former are presented.Comment: 24 pages, to appear in GR