Deterministic Controlled-NOT gate for single-photon two-qubit quantum logic

We demonstrate a robust implementation of a deterministic linear-optical Controlled-NOT (CNOT) gate for single-photon two-qubit quantum logic. A polarization Sagnac interferometer with an embedded 45$^{\circ}$-oriented dove prism is used to enable the polarization control qubit to act on the momentum (spatial) target qubit of the same photon. The CNOT gate requires no active stabilization because the two spatial modes share a common path, and it is used to entangle the polarization and momentum qubits.Comment: 10 pages, 4 figures. Typos corrected, referee comments and correction

Constraining the true nature of an exotic binary in the core of NGC 6624

We report on the identification of the optical counterpart to Star1, the exotic object serendipitously discovered by Deutsch et al. in the core of the Galactic globular cluster NGC 6624. Star1 has been classified by Deutsch et al. as either a quiescent Cataclysmic Variable or a low-mass X-ray binary. Deutsch et al. proposed StarA as possible optical counterpart to this object. We used high-resolution images obtained with the Hubble Space Telescope to perform a variability analysis of the stars close to the nominal position of Star1. While no variability was detected for StarA, we found another star, here named COM_Star1, showing a clear sinusoidal light modulation with amplitude \Delta m_F435W~0.7 mag and orbital period of P_orb~98 min. The shape of the light curve is likely caused by strong irradiation by the primary heating one hemisphere of the companion, thus suggesting a quite hot primary.Comment: Accepted for publication by ApJ Letters; 6 pages, 5 figure

Secure self-calibrating quantum random bit generator

Random bit generators (RBGs) are key components of a variety of information processing applications ranging from simulations to cryptography. In particular, cryptographic systems require "strong" RBGs that produce high-entropy bit sequences, but traditional software pseudo-RBGs have very low entropy content and therefore are relatively weak for cryptography. Hardware RBGs yield entropy from chaotic or quantum physical systems and therefore are expected to exhibit high entropy, but in current implementations their exact entropy content is unknown. Here we report a quantum random bit generator (QRBG) that harvests entropy by measuring single-photon and entangled two-photon polarization states. We introduce and implement a quantum tomographic method to measure a lower bound on the "min-entropy" of the system, and we employ this value to distill a truly random bit sequence. This approach is secure: even if an attacker takes control of the source of optical states, a secure random sequence can be distilled.Comment: 5 pages, 2 figure

Metronomic Chemotherapy with Vinorelbine Produces Clinical Benefit and Low Toxicity in Frail Elderly Patients Affected by Advanced Non-Small Cell Lung Cancer

Lung cancer is the leading cause of death worldwide. The treatment choice for advanced stage of lung cancer may depend on histotype, performance status (PS), age, and comorbidities. In the present study, we focused on the effect of metronomic vinorelbine treatment in elderly patients with advanced unresectable non-small cell lung cancer (NSCLC). Methods. From January 2016 to December 2016, 44 patients affected by non-small cell lung cancer referred to our oncology day hospital were progressively analyzed. The patients were treated with oral vinorelbine 30 mg x 3/wk or 40 mg x 3/wk meaning one day on and one day off. The patients were older than 60, stage IIIB or IV, ECOG PS ≥ 1, and have at least one important comorbidity (renal, hepatic, or cardiovascular disease). The schedule was based on ECOG-PS and comorbidities. The primary endpoint was progression-free survival (PFS). PFS was used to compare patients based on different scheduled dosage (30 or 40 mg x3/weekly) and age (more or less than 75 years old) as exploratory analysis. We also evaluated as secondary endpoint toxicity according to Common Toxicity Criteria Version 2.0. Results. Vinorelbine showed a good safety profile at different doses taken orally and was effective in controlling cancer progression. The median overall survival (OS) was 12 months. The disease control rate (DCR) achieved 63%. The median PFS was 9 months. A significant difference in PFS was detected comparing patients aged below with those over 75, and the HR value was 0.72 (p<0.05). Not significant was the difference between groups with different schedules. Conclusions. This study confirmed the safety profile of metronomic vinorelbine and its applicability for patients unfit for standard chemotherapies and adds the possibility of considering this type of schedule not only for very elderly patients

Mask-R 2 CNN: a distance-field regression version of Mask-RCNN for fetal-head delineation in ultrasound images

Background and objectives: Fetal head-circumference (HC) measurement from ultrasound (US) images provides useful hints for assessing fetal growth. Such measurement is performed manually during the actual clinical practice, posing issues relevant to intra- and inter-clinician variability. This work presents a fully automatic, deep-learning-based approach to HC delineation, which we named Mask-R2CNN. It advances our previous work in the field and performs HC distance-field regression in an end-to-end fashion, without requiring a priori HC localization nor any postprocessing for outlier removal. Methods: Mask-R2CNN follows the Mask-RCNN architecture, with a backbone inspired by feature-pyramid networks, a region-proposal network and the ROI align. The Mask-RCNN segmentation head is here modified to regress the HC distance field. Results: Mask-R2CNN was tested on the HC18 Challenge dataset, which consists of 999 training and 335 testing images. With a comprehensive ablation study, we showed that Mask-R2CNN achieved a mean absolute difference of 1.95 mm (standard deviation = ± 1.92 mm), outperforming other approaches in the literature. Conclusions: With this work, we proposed an end-to-end model for HC distance-field regression. With our experimental results, we showed that Mask-R2CNN may be an effective support for clinicians for assessing fetal growth

Strong low-frequency quantum correlations from a four-wave mixing amplifier

We show that a simple scheme based on nondegenerate four-wave mixing in a hot atomic vapor behaves like a near-perfect phase-insensitive optical amplifier, which can generate bright twin beams with a measured quantum noise reduction in the intensity difference of more than 8 dB, close to the best optical parametric amplifiers and oscillators. The absence of a cavity makes the system immune to external perturbations, and the strong quantum noise reduction is observed over a large frequency range.Comment: 4 pages, 4 figures. Major rewrite of the previous version. New experimental results and further analysi

Variable Stars in Local Group Galaxies. I: Tracing the Early Chemical Enrichment and Radial Gradients in the Sculptor dSph with RR Lyrae Stars

We identified and characterized the largest (536) RR Lyrae (RRL) sample in a Milky Way dSph satellite (Sculptor) based on optical photometry data collected over $\sim$24 years. The RRLs display a spread in V-magnitude ($\sim$0.35 mag) which appears larger than photometric errors and the horizontal branch (HB) luminosity evolution of a mono-metallic population. Using several calibrations of two different reddening free and metal independent Period-Wesenheit relations we provide a new distance estimate $\mu$=19.62 mag ($\sigma_{\mu}$=0.04 mag) that agrees well with literature estimates. We constrained the metallicity distribution of the old population, using the $M_I$ Period-Luminosity relation, and we found that it ranges from -2.3 to -1.5 dex. The current estimate is narrower than suggested by low and intermediate spectroscopy of RGBs ($\Delta$[Fe/H] $\le$ 1.5). We also investigated the HB morphology as a function of the galactocentric distance. The HB in the innermost regions is dominated by red HB stars and by RRLs, consistent with a more metal-rich population, while in the outermost regions it is dominated by blue HB stars and RRLs typical of a metal-poor population. Our results suggest that fast chemical evolution occurred in Sculptor, and that the radial gradients were in place at an early epoch.Comment: 10 pages, 5 figures, MNRAS accepte

Two-photon coincident-frequency-entanglement via extended phase matching

We demonstrate a new class of frequency-entangled states generated via spontaneous parametric down-conversion under extended phase matching conditions. Biphoton entanglement with coincident signal and idler frequencies is observed over a broad bandwidth in periodically poled KTiOPO$_4$. We demonstrate high visibility in Hong-Ou-Mandel interferometric measurements under pulsed pumping without spectral filtering, which indicates excellent frequency indistinguishability between the down-converted photons. The coincident-frequency entanglement source is useful for quantum information processing and quantum measurement applications.Comment: 4 pages, 3 figures, submitted to PR