Terbinafina: Un nuovo farmaco antimicotico nel trattamento dell'aspergillosi polmonare : Studio pilota

Background and aim of the work. Bronchopulmonary aspergillosis is a spectrum of diseases extending from a harmless saprophytic state to rapidly fatal acute invasive conditions; their increasing frequency is due to the wide use of steroids and other immunosuppressive drugs. Conventional treatments are often ineffective and associated with side-effects. The aim of this work was to evaluate a mew allylamine antimycotic drug (terbinafine) in the treatment of lower respiratory tract mycotic infections unresponsive to conventional therapy. Methods. We report on 14 immunocompetent patients, who were unresponsive to conventional therapy or relapsed or showed untoward effects to conventional antifungal treatments. Diagnosis was based on compatible clinical history, indentification of mycotic microrganisms in biological fluids, chest x-ray and CT scan abnormalities, respiratory function test, positive skin tests and serum presence of Aspergillus precipitine. These patients were treated with terbinafine at oral doses ranging from 5 to 15 mg/kg/day for 84-264 days, depending on clinical severity of the disease, clinical course and compliance. Results. We obtained eradication of Aspergillus fumigatus (AF) in 11 patients: 3 of them obtained complete resolution of signs and symptoms; 4 a partial response with major clinical improvement and the last 4 a partial response with minor improvement. In other 3 patients, who were AF negative but with positive precipitins, we obtained one complete remission, and a clinical radiological improvement on 2 cases. Conclusion. These preliminary findings indicate that terbinafine appears to be effective in the treatment of bronchopulmonary aspergillosis in non immunocompromised patients. Controlled trials are warranted to evaluate terbinafine in pulmonary mycotic infections

Atti del Seminario Politiche culturali e scenari economici per il futuro del cinema italiano

Con meno 70% di spettatori rispetto all’epoca pre-pandemica, il cinema italiano vive un declino che appare inarrestabile, i cui sintomi erano però comparsi prima della pandemia. Il lockdown, con la serrata delle sale, è stato semmai l’acceleratore della crisi. Che fare? Arrendersi a un destino che appare già scritto o coltivare l’ottimismo della volontà, nuotando controcorrente spinti da una rinnovata azione politico-culturale? Il tema, dall’importanza fondamentale visto il peso dell’audiovisivo per la nostra economia, è stato al centro del seminario 'Politiche culturali e scenari economici per il futuro del cinema italiano' organizzato dall’Ente dello Spettacolo a Castiglione del Lago (PG), in occasione della manifestazione Castiglione Cinema - RdC incontra e nell’ambito del progetto “Il 75° anniversario della Fondazione Ente dello Spettacolo”. Questo volume, articolato in due parti (Scenari e Prospettive), ne raccoglie gli atti

Direct Synthesis of Vinylidene Fluoride-Based Amphiphilic Diblock Copolymers by RAFT/MADIX Polymerization

International audienceWe herein report the synthesis of original vinylidene fluoride (VDF)-based amphiphilic block copolymers by RAFT/MADIX polymerization. The controlled polymerization of VDF could be successfully mediated by a xanthate chain transfer agent as evidenced by SEC, 19F NMR and MALDI-TOF MS analysis. Copolymers of VDF and perfluoro(methyl vinyl ether) (PMVE) of varying controlled chain lengths were also obtained. Finally, the direct synthesis of main-chain fluorinated amphiphilic block copolymers was performed from hydrophilic poly(N,N-dimethylacrylamide) macro-RAFT agents. It is expected that this finding will open interesting perspectives for the development of new class of polymeric surfactants for the stabilization of emulsions based on water and supercritical carbon dioxide media