10,250 research outputs found
Niobium hyperfine structure in crystal calcium tungstate
A study of the niobium hyperfine structure in single crystal calcium tungstate was made by the combination of the technique of electron paramagnetic resonance and electron nuclear double resonance (EPR/ENDOR). The microwave frequency was about 9.4 GHz and the radio frequency from 20MHz to 70 MHz. The rare earth ions Nd(3+), U(3+), or Tm(3+) were added as the charge compensator for Nb(5+). To create niobium paramagnetic centers, the sample was irradiated at 77 deg K with a 10 thousand curie Co-60 gamma source for 1 to 2 hours at a dose rate of 200 K rads per hour and then transferred quickly into the cavity. In a general direction of magnetic field, the spectra showed 4 sets of 10 main lines corresponding to 4 nonequivalent sites of niobium with I = 9/2. These 4 sets of lines coalesced into 2 sets of 10 in the ab-plane and into a single set of 10 along the c-axis. This symmetry suggested that the tungsten ions are substituted by the niobium ions in the crystal
Jet array impingement flow distributions and heat transfer characteristics. Effects of initial crossflow and nonuniform array geometry
Two-dimensional arrays of circular air jets impinging on a heat transfer surface parallel to the jet orifice plate are considered. The jet flow, after impingement, is constrained to exit in a single direction along the channel formed by the jet orifice plate and the heat transfer surface. The configurations considered are intended to model those of interest in current and contemplated gas turbine airfoil midchord cooling applications. The effects of an initial crossflow which approaches the array through an upstream extension of the channel are considered. Flow distributions as well as heat transfer coefficients and adiabatic wall temperatures resolved to one streamwise hole spacing were measured as a function of the initial crossflow rate and temperature relative to the jet flow rate and temperature. Both Nusselt number profiles and dimensionless adiabatic wall temperature (effectiveness) profiles are presented and discussed. Special test results which show a significant reduction of jet orifice discharge coefficients owing to the effect of a confined crossflow are also presented, along with a flow distribution model which incorporates those effects. A nonuniform array flow distribution model is developed and validated
Inhibition of dengue virus replication by novel inhibitors of RNA-dependent RNA polymerase and protease activities
Dengue virus (DENV) is the leading mosquito-transmitted viral infection in the world. With more than 390 million new infections annually, and up to 1 million clinical cases with severe disease manifestations, there continues to be a need to develop new antiviral agents against dengue infection. In addition, there is no approved anti-DENV agents for treating DENV-infected patients. In the present study, we identified new compounds with anti-DENV replication activity by targeting viral replication enzymes – NS5, RNA-dependent RNA polymerase (RdRp) and NS3 protease, using cell-based reporter assay. Subsequently, we performed an enzyme-based assay to clarify the action of these compounds against DENV RdRp or NS3 protease activity. Moreover, these compounds exhibited anti-DENV activity in vivo in the ICR-suckling DENV-infected mouse model. Combination drug treatment exhibited a synergistic inhibition of DENV replication. These results describe novel prototypical small anti-DENV molecules for further development through compound modification and provide potential antivirals for treating DENV infection and DENV-related diseases
Production of large-particle-size monodisperse latexes
The research program achieved two objectives: (1) it has refined and extended the experimental techniques for preparing monodisperse latexes in quantity on the ground up to a particle diameter of 10 microns; and (2) it has demonstrated that a microgravity environment can be used to grow monodisperse latexes to larger sizes, where the limitations in size have yet to be defined. The experimental development of the monodisperse latex reactor (MLR) and the seeded emulsion polymerizations carried out in the laboratory prototype of the flight hardware, as a function of the operational parameters is discussed. The emphasis is directed towards the measurement, interpretation, and modeling of the kinetics of seeded emulsion polymerization and successive seeded emulsion polymerization. The recipe development of seeded emulsion polymerization as a function of particle size is discussed. The equilibrium swelling of latex particles with monomers was investigated both theoretically and experimentally. Extensive studies are reported on both the type and concentration of initiators, surfactants, and inhibitors, which eventually led to the development of the flight recipes. The experimental results of the flight experiments are discussed, as well as the experimental development of inhibition of seeded emulsion polymerization in terms of time of inhibition and the effect of inhibitors on the kinetics of polymerization
The first products made in space: Monodisperse latex particles
The preparation of large particle size 3 to 30 micrometer monodisperse latexes in space confirmed that original rationale unequivocally. The flight polymerizations formed negligible amounts of coagulum as compared to increasing amounts for the ground-based polymerizations. The number of offsize large particles in the flight latexes was smaller than in the ground-based latexes. The particle size distribution broadened and more larger offsize particles were formed when the polymerizations of the partially converted STS-4 latexes were completed on Earth. Polymerization in space also showed other unanticipated advantages. The flight latexes had narrower particle size distributions than the ground-based latexes. The particles of the flight latexes were more perfect spheres than those of the ground-based latexes. The superior uniformity of the flight latexes was confirmed by the National Bureau of Standards acceptance of the 10 micrometer STS-6 latex and the 30 micrometer STS-11 latexes as Standard Reference Materials, the first products made in space for sale on Earth. The polymerization rates in space were the same as those on Earth within experimental error. Further development of the ground-based polymerization recipes gave monodisperse particles as large as 100 micrometer with tolerable levels of coagulum, but their uniformity was significantly poorer than the flight latexes. Careful control of the polymerization parameters gave uniform nonspherical particles: symmetrical and asymmetrical doublets, ellipsoids, egg-shaped, ice cream cone-shaped, and popcorn-shaped particles
Salient collinear grouping diminishes local salience in visual search: An eye movement study
SCI Impact Factor(2011)=2.417[[abstract]]Our eyes and attention are easily attracted to salient items in search displays. When a target is spatially overlapped with a salient distractor (overlapping target), it is usually detected more easily than when it is not (nonoverlapping target). Jingling and Tseng (2013), however, found that a salient distractor impaired visual search when the distractor was comprised of more than nine bars collinearly aligned to each other. In this study, we examined whether this search impairment is due to reduction of salience on overlapping targets. We used the short-latency saccades as an index for perceptual salience. Results showed that a long collinear distractor decreases perceptual salience of local overlapping targets in comparison to nonoverlapping targets, reflected by a smaller proportion of the short-latency saccades. Meanwhile, a salient noncollinear distractor increases salience of overlapping targets. Our results led us to conclude that a long collinear distractor diminishes the perceptual salience of the target, a factor which poses a counter-intuitive condition in which a target on a salient region becomes less salient. We discuss the possible causes for our findings, including crowding, the global precedence effect, and the filling-in of a collinear contour.[[notice]]補正完畢[[incitationindex]]SCI[[ispeerreviewed]]Y[[booktype]]電子版[[countrycodes]]US
Experimental evidence for the interplay between individual wealth and transaction network
We conduct a market experiment with human agents in order to explore the
structure of transaction networks and to study the dynamics of wealth
accumulation. The experiment is carried out on our platform for 97 days with
2,095 effective participants and 16,936 times of transactions. From these data,
the hybrid distribution (log-normal bulk and power-law tail) in the wealth is
observed and we demonstrate that the transaction networks in our market are
always scale-free and disassortative even for those with the size of the order
of few hundred. We further discover that the individual wealth is correlated
with its degree by a power-law function which allows us to relate the exponent
of the transaction network degree distribution to the Pareto index in wealth
distribution.Comment: 6 pages, 7 figure
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