Bridging the gap between methods research and the needs of policy makers: A review of the research priorities of the National Institute for Health and Clinical Excellence

Objectives: The aim of this study was to establish a list of priority topics for methods research to support decision making at the National Institute for Health and Clinical Excellence (NICE). Methods: Potential priorities for methods research topics were identified through a focused literature review, interviews, an email survey, a workshop and a Web-based feedback exercise. Participants were members of the NICE secretariat and its advisory bodies, representatives from academia, industry, and other organizations working closely with NICE. The Web exercise was open to anyone to complete but publicized among the above groups. Results: A list of potential topics was collated. Priorities for further research differed according to the type of respondent and the extent to which they work directly with NICE. Priorities emerging from the group closest to NICE included: methodology for indirect and mixed treatment comparisons; synthesis of qualitative evidence; research relating to the use of quality-adjusted life-years (QALYs) in decision making; methods and empirical research for establishing the cost-effectiveness threshold; and determining how data on the uncertainty of effectiveness and cost-effectiveness data should be taken into account in the decision-making process. Priorities emerging from the broadest group of respondents (through the Web exercise) included: methods for extrapolating beyond evidence observed in trials, methods for capturing benefits not included in the QALY and methods to assess when technologies should be recommended in the context of further evidence gathering. Conclusions: Consideration needs to be given to the needs of those who use the outputs of research for decision making when determining priorities for future methods research.NIHR Medical Research Council

Calibration of transonic and supersonic wind tunnels

State-of-the art instrumentation and procedures for calibrating transonic (0.6 less than M less than 1.4) and supersonic (M less than or equal to 3.5) wind tunnels were reviewed and evaluated. Major emphasis was given to transonic tunnels. Continuous, blowdown and intermittent tunnels were considered. The required measurements of pressure, temperature, flow angularity, noise and humidity were discussed, and the effects of measurement uncertainties were summarized. A comprehensive review of instrumentation currently used to calibrate empty tunnel flow conditions was included. The recent results of relevant research are noted and recommendations for achieving improved data accuracy are made where appropriate. It is concluded, for general testing purposes, that satisfactory calibration measurements can be achieved in both transonic and supersonic tunnels. The goal of calibrating transonic tunnels to within 0.001 in centerline Mach number appears to be feasible with existing instrumentation, provided correct calibration procedures are carefully followed. A comparable accuracy can be achieved off-centerline with carefully designed, conventional probes, except near Mach 1. In the range 0.95 less than M less than 1.05, the laser Doppler velocimeter appears to offer the most promise for improved calibration accuracy off-centerline

Studying clinical reasoning, part 2: Applying social judgement theory

Part 1 of this paper (Harries and Harries 2001) examined the reasoning studies of the 1980s and 1990s and critiqued the ethnographic and informationprocessing approaches, based on stated information use. The need for an approach that acknowledged the intuitive nature of experienced thinkers’ reasoning was identified. Part 2 describes such an approach ± social judgement theory ± and presents a pilot application in occupational therapy research. The method used is judgement analysis. The issue under study is that of prioritisation policies in community mental health work. The results present the prioritisation policies of four occupational therapists in relation to managing community mental health referrals

The Amish Population: County Estimates and Settlement Patterns

This article presents the findings of a county-based estimate of the Amish population. The results are from work commissioned by the Association of Statisticians of American Religious Bodies for the recently released 2010 U.S. Religion Census, plus research and updates associated with tracking the growth and geographic spread of Amish settlements in North America. County estimates are restricted to Amish church groups who rely on horse-and-buggy for travel. Using the terminology of the larger ASARB report, we break the Amish population into three groups: communicants (baptized members), non-baptized members (mostly children/young adults still living at home), and adherents (both baptized and non-baptized Amish). We report on population totals, state by state. We include tables showing the 25 largest Amish settlements, the 25 counties with the largest Amish populations, and the 25 counties with the highest percentage of Amish to their total population. Based on current rates of growth, we project the Amish population, decade by decade, to 2050.Association of Statisticians of American Religious BodiesInitiative in Population ResearchThe Ohio State UniversityHeritage Historical Librar

Identifying Blood Biomarkers and Physiological Processes That Distinguish Humans with Superior Performance under Psychological Stress

BACKGROUND:Attrition of students from aviation training is a serious financial and operational concern for the U.S. Navy. Each late stage navy aviator training failure costs the taxpayer over $1,000,000 and ultimately results in decreased operational readiness of the fleet. Currently, potential aviators are selected based on the Aviation Selection Test Battery (ASTB), which is a series of multiple-choice tests that evaluate basic and aviation-related knowledge and ability. However, the ASTB does not evaluate a person's response to stress. This is important because operating sophisticated aircraft demands exceptional performance and causes high psychological stress. Some people are more resistant to this type of stress, and consequently better able to cope with the demands of naval aviation, than others. METHODOLOGY/PRINCIPAL FINDINGS:Although many psychological studies have examined psychological stress resistance none have taken advantage of the human genome sequence. Here we use high-throughput -omic biology methods and a novel statistical data normalization method to identify plasma proteins associated with human performance under psychological stress. We identified proteins involved in four basic physiological processes: innate immunity, cardiac function, coagulation and plasma lipid physiology. CONCLUSIONS/SIGNIFICANCE:The proteins identified here further elucidate the physiological response to psychological stress and suggest a hypothesis that stress-susceptible pilots may be more prone to shock. This work also provides potential biomarkers for screening humans for capability of superior performance under stress

An Eye-Tracking Methodology for Testing Consumer Preference of Display Trays in a Simulated Retail Environment

Display trays have traditionally been used to support distribution packaging and retail stocking. Yet, it is becoming increasingly common to find display trays as devices to garner attention and increase the shelf presence of packaging. This paper presents a method for testing consumer preference of display trays for liquid dish soap and canned tomatoes in CUShop™, a consumer experience laboratory, using eye-tracking technology. It was hypothesized that display trays would increase total fixation duration and decrease time to first fixation on the respective products tested. However, it was determined that attention to products in a display tray was less favorable to products not in a display tray. Experimental results are limited because of the many variables that exist for display trays. If further studies were to be conducted on a larger variety of display trays using the methodology described, the appeal and attention value of display trays could be comprehensively understood

The Effect of Decorative Foil Stamping on Consumer Attention

Packaging plays a crucial role in communicating product benefits to consumers. Oftentimes, designers use high visibility enhancements to differentiate packaging within the competitive array. Although luxury brands commonly use enhanced graphical and printing techniques to convey high quality products, many private label package designers are also utilizing enhancements to attract attention to their products. This research sought to understand how incorporating foil stamping to the primary panel of fast moving consumer good packaging will affect consumer attention and purchase preference. Through the collection of quantitative data, consumer attention and purchase preference were evaluated. Three different products were selected for evaluation for the study: popcorn, cereal, and boxed pasta dinners. A total of 172 participants completed the study, which took place in a realistic and immersive shopping environment (CUshop™). Two eye tracking metrics were collected using mobile eye tracking technology. Participants completed a qualitative survey, which recorded basic demographic information. Significance tests were conducted to test for statistical differences in consumer attention behavior as well as purchase decision between the foil and control packages. It was determined that foil stamping did significantly (α =0.05) affect consumer attention towards the respective product compared to the control, yet the effect was not consistent. Eye tracking metrics varied across the products and categories tested; some foil stamped samples positively affected consumer attention, others negatively and some had no effect whatsoever. Results show that foil stamping can be a highly strategic influencer (both positively and negatively) on consumer attention and purchase decision. However, it is recommended that this enhancement be tested within an in-context environment to ensure it benefits the brand and product within the competitive array

Low-ionization Line Emission from Starburst Galaxies: A New Probe of Galactic-Scale Outflows

We study the kinematically narrow, low-ionization line emission from a bright, starburst galaxy at z = 0.69 using slit spectroscopy obtained with Keck/LRIS. The spectrum reveals strong absorption in MgII and FeII resonance transitions with Doppler shifts of -200 to -300 km/s, indicating a cool gas outflow. Emission in MgII near and redward of systemic velocity, in concert with the observed absorption, yields a P Cygni-like line profile similar to those observed in the Ly alpha transition in Lyman Break Galaxies. Further, the MgII emission is spatially resolved, and extends significantly beyond the emission from stars and HII regions within the galaxy. Assuming the emission has a simple, symmetric surface brightness profile, we find that the gas extends to distances > ~7 kpc. We also detect several narrow FeII* fine-structure lines in emission near the systemic velocity, arising from energy levels which are radiatively excited directly from the ground state. We suggest that the MgII and FeII* emission is generated by photon scattering in the observed outflow, and emphasize that this emission is a generic prediction of outflows. These observations provide the first direct constraints on the minimum spatial extent and morphology of the wind from a distant galaxy. Estimates of these parameters are crucial for understanding the impact of outflows in driving galaxy evolution.Comment: Submitted to ApJL. 6 pages, 4 figures. Uses emulateapj forma