Leptoquarks decaying to a top quark and a charged lepton at hadron colliders

We study the sensitivity of the Tevatron and the 7 TeV LHC to a leptoquark S coupling to a top quark and a charged lepton L (= e, mu, or tau). For the Tevatron, we focus on the case m_S < m_t, where the leptoquark pair production cross section is large, and the decay is three-body: S --> W b L^{\pm}. We argue that existing Tevatron observations could exclude m_S \lsim 160 GeV. For m_S > m_t, we show that the LHC experiments with low integrated luminosity could be sensitive to such leptoquarks decaying to tl^{\pm} with l= mu or tau.Comment: 13 pages, 6 figures, minor changes (typos

Associations between cadmium exposure and neurocognitive test scores in a cross-sectional study of US adults

Background: Low-level environmental cadmium exposure and neurotoxicity has not been well studied in adults. Our goal was to evaluate associations between neurocognitive exam scores and a biomarker of cumulative cadmium exposure among adults in the Third National Health and Nutrition Examination Survey (NHANES III). Methods: NHANES III is a nationally representative cross-sectional survey of the U.S. population conducted between 1988 and 1994. We analyzed data from a subset of participants, age 20–59, who participated in a computer-based neurocognitive evaluation. There were four outcome measures: the Simple Reaction Time Test (SRTT: visual motor speed), the Symbol Digit Substitution Test (SDST: attention/perception), the Serial Digit Learning Test (SDLT) trials-to-criterion, and the SDLT total-error-score (SDLT-tests: learning recall/short-term memory). We fit multivariable-adjusted models to estimate associations between urinary cadmium concentrations and test scores. Results: 5662 participants underwent neurocognitive screening, and 5572 (98%) of these had a urinary cadmium level available. Prior to multivariable-adjustment, higher urinary cadmium concentration was associated with worse performance in each of the 4 outcomes. After multivariable-adjustment most of these relationships were not significant, and age was the most influential variable in reducing the association magnitudes. However among never-smokers with no known occupational cadmium exposure the relationship between urinary cadmium and SDST score (attention/perception) was significant: a 1 μg/L increase in urinary cadmium corresponded to a 1.93% (95%CI: 0.05, 3.81) decrement in performance. Conclusions: These results suggest that higher cumulative cadmium exposure in adults may be related to subtly decreased performance in tasks requiring attention and perception, particularly among those adults whose cadmium exposure is primarily though diet (no smoking or work based cadmium exposure). This association was observed among exposure levels that have been considered to be without adverse effects and these levels are common in U.S. adults. Thus further research into the potential neurocognitive effects of cadmium exposure is warranted. Because cumulative cadmium exposure may mediate some of the effects of age and smoking on cognition, adjusting for these variables may result in the underestimation of associations with cumulative cadmium exposure. Prospective studies that include never-smokers and non-occupationally exposed individuals are needed to clarify these issues

Electronic bill presentment and payment--is it just a click away?

This article addresses the following questions about electronic presentment and payment (EBPP) in the business-to-consumer marketplace: Why aren't electronically presented bills always paid electronically? And, if EBPP does aid in the migration to fully electronic end-to-end payment, what are the barriers to its adoption.Payment systems ; Electronic funds transfers

Formal Verification of Arithmetic Circuits by Function Extraction

The paper presents an algebraic approach to functional verification of gate-level, integer arithmetic circuits. It is based on extracting a unique bit-level polynomial function computed by the circuit directly from its gate-level implementation. The method can be used to verify the arithmetic function computed by the circuit against its known specification, or to extract an arithmetic function implemented by the circuit. Experiments were performed on arithmetic circuits synthesized and mapped onto standard cells using ABC system. The results demonstrate scalability of the method to large arithmetic circuits, such as multipliers, multiply-accumulate, and other elements of arithmetic datapaths with up to 512-bit operands and over 2 million gates. The results show that our approach wins over the state-of-the-art SAT/SMT solvers by several orders of magnitude of CPU time. The procedure has linear runtime and memory complexity, measured by the number of logic gates

Low energy n-\nuc{3}{H} scattering : a novel testground for nuclear interaction

The low energy n-\nuc{3}{H} elastic cross sections near the resonance peak are calculated by solving the 4-nucleon problem with realistic NN interactions. Three different methods -- Alt, Grassberger and Shandas (AGS), Hyperspherical Harmonics and Faddeev-Yakubovsky -- have been used and their respective results are compared. We conclude on a failure of the existing NN forces to reproduce the n-\nuc{3}{H} total cross section.Comment: To be published in Phys. Rev.

Interactions of lipopolysaccharide with lipid membranes, raft models — A solid state NMR study

AbstractLipopolysaccharide (LPS) is a major component of the external leaflet of bacterial outer membranes, key pro-inflammatory factor and an important mediator of host–pathogen interactions. In host cells it activates the complement along with a pro-inflammatory response via a TLR4-mediated signalling cascade and shows preference for cholesterol-containing membranes. Here, we use solid state 13C and 31P MAS NMR to investigate the interactions of LPS from three bacterial species, Brucella melitensis, Klebsiella pneumoniae and Escherichia coli, with mixed lipid membranes, raft models. All endotoxin types are found to be pyrophosphorylated and Klebsiellar LPS is phosphonylated, as well. Carbon-13 MAS NMR indicates an increase in lipid order in the presence of LPS. Longitudinal 31P relaxation, providing a direct probe of LPS molecular and segmental mobility, reveals a significant reduction in 31P T1 times and lower molecular mobility in the presence of ternary lipid mixtures. Along with the ordering effect on membrane lipid, this suggests a preferential partitioning of LPS into ordered bilayer sphingomyelin/cholesterol-rich domains. We hypothesise that this is an important evolutionary drive for the selection of GPI-anchored raft-associated LPS-binding proteins as a first line of response to membrane-associated LPS

Chemical Synthesis at Surfaces with Atomic Precision: Taming Complexity and Perfection

Scanning probe microscopy (SPM) is a powerful tool to study the structure and dynamics of molecules at surfaces and interfaces as well as to precisely manipulate atoms and molecules by applying an external force, by inelastic electron tunneling, or by means of an electric field. The rapid development of these SPM manipulation modes made it possible to achieve fine‐control over fundamental processes in the physics of interfaces as well as chemical reactivity, such as adsorption, diffusion, bond formation, and bond dissociation with precision at the single atom/molecule level. Their controlled use for the fabrication of atomic‐scale structures and synthesis of new, perhaps uncommon, molecules with programmed properties are reviewed. Opportunities and challenges towards the development of complex chemical systems are discussed, by analyzing potential future impacts in nanoscience and nanotechnology.journal articlereview2019 Dec 192019 11 28importe

Market segments based on the dominant movement patterns of tourists

This paper presents an innovative method for tourist market segmentation-based on dominant movement patterns of tourists; that is, the travel sequences or patterns used by tourists most frequently. There were three steps to achieve this goal. In the first step, general log-linear models were adopted to identify the dominant movement patterns, while the second step was to discover the characteristics of the groups of tourists who travelled with these patterns. The Expectation–Maximisation algorithm was then used to partition tourist segments in terms of socio-demographic and travel behavioural variables. The third step was to select target markets based upon the earlier analysis. These methods were applied to a sample of tourists, over the period of a week, on Phillip Island, Victoria, Australia. A significant outcome of this research is that it will assist tourism organisations to identify tourism market segments and develop better tour packages and more efficient marketing strategies aligned to the characteristics of the tourists

Recognition of membrane sterols by polyene antifungals amphotericin B and natamycin, a 13C MAS NMR Study

The molecular action of polyene macrolides with antifungal activity, amphotericin B and natamycin, involves recognition of sterols in membranes. Physicochemical and functional studies have contributed details to understanding the interactions between amphotericin B and ergosterol and, to a lesser extent, with cholesterol. Fewer molecular details are available on interactions between natamycin with sterols. We use solid state 13C MAS NMR to characterize the impact of amphotericin B and natamycin on mixed lipid membranes of DOPC/cholesterol or DOPC/ergosterol. In cholesterol-containing membranes, amphotericin B addition resulted in marked increase in both DOPC and cholesterol 13C MAS NMR linewidth, reflecting membrane insertion and cooperative perturbation of the bilayer. By contrast, natamycin affects little either DOPC or cholesterol linewidth but attenuates cholesterol resonance intensity preferentially for sterol core with lesser impact on the chain. Ergosterol resonances, attenuated by amphotericin B, reveal specific interactions in the sterol core and chain base. Natamycin addition selectively augmented ergosterol resonances from sterol core ring one and, at the same time, from the end of the chain. This puts forward an interaction model similar to the head-to-tail model for amphotericin B/ergosterol pairing but with docking on opposite sterol faces. Low toxicity of natamycin is attributed to selective, non-cooperative sterol engagement compared to cooperative membrane perturbation by amphotericin B