Morphing of Triangular Meshes in Shape Space

We present a novel approach to morph between two isometric poses of the same non-rigid object given as triangular meshes. We model the morphs as linear interpolations in a suitable shape space $\mathcal{S}$. For triangulated 3D polygons, we prove that interpolating linearly in this shape space corresponds to the most isometric morph in $\mathbb{R}^3$. We then extend this shape space to arbitrary triangulations in 3D using a heuristic approach and show the practical use of the approach using experiments. Furthermore, we discuss a modified shape space that is useful for isometric skeleton morphing. All of the newly presented approaches solve the morphing problem without the need to solve a minimization problem.Comment: Improved experimental result

Relationships and reputation: Managing intercultural health communication issues

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Interpreting university sport policy in England: seeking a purpose in turbulent times?

Given the fundamental change in political landscape of current higher education in England, it is timely to (re)consider the purpose of university sport and its fit with national sports policy. This research investigates the purpose of university sport; how university sport fits with national sport strategies, if at all; and whether universities and sport policy are capitalising on Higher Education (HE) sport. An interpretivistic public policy analysis was carried out using eight semi-structured interviews with senior leaders of sport within universities in one region of the north of England. In addition, documentary analysis was examined. Outcomes illustrate the changed landscape for university sport in England with the key purpose of sport focusing on wider student experience; to engage students in sport and contribute to enhancing student recruitment, retention, satisfaction, mental health and graduate employability. However, there were mixed views as to whether senior university leaders were fully aware of the extent of the role of sport. Strategic drivers were more internal than external although universities recognised the value of working in a symbiotic relationship with internal and external stakeholders. Recommendations are offered for university leaders and sport policy makers on how to better capitalise on sport in England and beyond

Spatio-temporal feature extraction in sensory electroneurographic signals

The recording and analysis of peripheral neural signal can provide insight for various prosthetic and bioelectronics medicine applications. However, there are few studies that investigate how informative features can be extracted from population activity electroneurographic (ENG) signals. In this study, five feature extraction frameworks were implemented on sensory ENG datasets and their classification performance was compared. The datasets were collected in acute rat experiments where multi-channel nerve cuffs recorded from the sciatic nerve in response to proprioceptive stimulation of the hindlimb. A novel feature extraction framework, which incorporates spatio-temporal focus and dynamic time warping, achieved classification accuracies above 90% while keeping a low computational cost. This framework outperformed the remaining frameworks tested in this study and has improved the discrimination accuracy of the sensory signals. Thus, this study has extended the tools available to extract features from sensory population activity ENG signals. This article is part of the theme issue ‘Advanced neurotechnologies: translating innovation for health and well-being’

An empirical mean-field model of symmetry-breaking in a turbulent wake

Improved turbulence modeling remains a major open problem in mathematical physics. Turbulence is notoriously challenging, in part due to its multiscale nature and the fact that large-scale coherent structures cannot be disentangled from small-scale fluctuations. This closure problem is emblematic of a greater challenge in complex systems, where coarse-graining and statistical mechanics descriptions break down. This work demonstrates an alternative data-driven modeling approach to learn nonlinear models of the coherent structures, approximating turbulent fluctuations as state-dependent stochastic forcing. We demonstrate this approach on a high-Reynolds number turbulent wake experiment, showing that our model reproduces empirical power spectra and probability distributions. The model is interpretable, providing insights into the physical mechanisms underlying the symmetry-breaking behavior in the wake. This work suggests a path toward low-dimensional models of globally unstable turbulent flows from experimental measurements, with broad implications for other multiscale systems

Src/FAK-mediated regulation of E-cadherin as a mechanism for controlling collective cell movement Insights from in vivo imaging

Recent advances in confocal and multi-photon microscopy, together with fluorescent probe development, have enabled cancer biology studies to go beyond the culture dish and interrogate cancer-associated processes in the complex in vivo environment. Regulation of the tumor suppressor protein E-cadherin plays an important role in cancer development and progression, and may contribute to the decision between ‘single cell’ and ‘collective invasion’ in vivo. Mounting evidence from in vitro and in vivo experiments places the two nonreceptor protein tyrosine kinases Src and Focal Adhesion Kinase at the heart of E-cadherin regulation and the crosstalk between integrins and cadherins. Here we discuss recent insights, attained using high-resolution fluorescent in vivo imaging, into the regulation of E-cadherin and collective invasion. We focus on the regulatory crosstalk between the Src/FAK signaling axis and E-cadherin in vivo

The importance of core outcome sets and developing one for neonatal care

It has been estimated that 85% of all clinical research is wasted. Suboptimal outcome selection is an important cause of waste because it leads to research that cannot be compared and may not be clinically relevant. A solution to this problem is the use of a core outcome set, a standardised set of outcomes recorded whenever research in a specific field is carried out. The methodology behind developing a core outcome set and how this is being applied in the Core Outcomes in Neonatology (COIN) project is described

A mutational analysis of the globotriaosylceramide-binding sites of verotoxin VT1.

Escherichia coli verotoxin, also known as Shiga-like toxin, binds to eukaryotic cell membranes via the glycolipid Gb(3) receptors which present the P(k) trisaccharide Galalpha(1-4)Galbeta(1-4)Glcbeta. Crystallographic studies have identified three P(k) trisaccharide (P(k)-glycoside) binding sites per verotoxin 1B subunit (VT1B) monomer while NMR studies have identified binding of P(k)-glycoside only at site 2. To understand the basis for this difference, we studied binding of wild type VT1B and VT1B mutants, defective at one or more of the three sites, to P(k)-glycoside and pentavalent P(k) trisaccharide (pentaSTARFISH) in solution and Gb(3) presented on liposomal membranes using surface plasmon resonance. Site 2 was the key site in terms of free trisaccharide binding since mutants altered at sites 1 and 3 bound this ligand with wild type affinity. However, effective binding of the pentaSTARFISH molecule also required a functional site 3, suggesting that site 3 promotes pentavalent binding of linked trisaccharides at site 1 and site 2. Optimal binding to membrane-associated Gb(3) involved all three sites. Binding of all single site mutants to liposomal Gb(3) was weaker than wild type VT1B binding. Site 3 mutants behaved as if they had reduced ability to enter into high avidity interactions with Gb(3) in the membrane context. Double mutants at site 1/site 3 and site 2/site 3 were completely inactive in terms of binding to liposomal Gb(3,) even though the site 1/site 3 mutant bound trisaccharide with almost wild type affinity. Thus site 2 alone is not sufficient to confer high avidity binding to membrane-localized Gb(3). Cytotoxic activity paralleled membrane glycolipid binding. Our data show that the interaction of verotoxin with the Gb(3) trisaccharide is highly context dependent and that a membrane environment is required for biologically relevant studies of the interaction