\u3ci\u3eAfghan poetry of the seventeenth century: being selections from the poems of Khushhal Khan Khatak, with translations and grammatical introductions; edited and compiled by C. E. Biddulph \u3c/i\u3e

Selections from the poems of Khushhal Khan Khatak with translations and grammatical introductions; edited and compiled by C. E. Biddulph

Associations between vitamin D levels and depressive symptoms in later life: evidence from the English Longitudinal Study of Ageing (ELSA)

BACKGROUND: A possible role of vitamin D in depression has received considerable attention, especially given the significant disability, mortality, and healthcare costs associated to depression and the high prevalence of vitamin D deficiency. METHODS: We investigated the cross-sectional associations between serum 25-hydroxyvitamin D (25OHD) levels and depressive symptoms (CES-D) in 5,607 older adults from the English Longitudinal Study of Ageing (ELSA). RESULTS: Overall, there was a significant association between low 25OHD levels and elevated depressive symptoms (odds ratio [OR] = 1.58, 95% confidence interval [CI] = 1.20–2.07 for the lowest quartile; OR = 1.45, 95% CI = 1.15–1.83 for <30 nmol/L cut-off and OR = 1.34, 95% CI = 1.10–1.62 for the ≤50 nmol/L cut-off) after adjustment for a wide range of covariates of clinical significance. Fully adjusted models showed that women in the lowest (OR = 1.67, 95% CI = 1.20–2.34) and second lowest (OR = 1.68, 95% CI = 1.20–2.35) quartiles of 25OHD as well as those with 25OHD levels <30 nmol/L (OR = 1.40, 95% CI = 1.06–1.86) and ≤50 nmol/L (OR = 1.35, 95% CI = 1.07–1.72) were more likely to report elevated depressive symptoms. For men, however, this association only remained significant for those with 25OHD levels of <30 nmol/L (OR = 1.60, 95% CI = 1.06–2.42) in the fully adjusted models. CONCLUSIONS: The independent and inverse association found between low 25OHD levels and elevated depressive symptoms suggests that vitamin D deficiency may be a risk factor for late-life depression, particularly among women. Whether our findings have any clinical meaning or not, additional data are needed from well-designed randomized controlled trials of vitamin D for the prevention and treatment of late-life depression

Vitamin D and inflammatory markers: cross-sectional analyses using data from the English Longitudinal Study of Ageing (ELSA)

Recent evidence suggests that low vitamin D concentrations are associated with increased levels of inflammatory markers. However, there are limited studies investigating associations between vitamin D levels and inflammatory markers in the general population and much of this evidence in older adults is inconclusive. Therefore, this study investigates the cross-sectional association of serum 25-hydroxyvitamin D (25(OH)D) levels with inflammatory markers in 5870 older English adults from wave 6 (2012-2013) of the English Longitudinal Study of Ageing (ELSA). ELSA is a large prospective observational study of community-dwelling people aged 50 years and over in England. Serum 25(OH)D levels, C-reactive protein (CRP) levels, plasma fibrinogen levels, white blood cell count (WBC), age, season of blood collection, waist circumference, total non-pension household wealth, measures of health and health behaviours that included depression, number of cardiovascular, non-cardiovascular conditions and difficulties in activities of daily living, smoking, and physical activity were measured. There was a significant negative association between low 25(OH)D levels (≤30 nmol/l) and CRP (OR 1·23, 95 % CI 1·00, 1·51) and WBC (OR 1·35, 95 % CI 1·13, 1·60) that remained after adjustment for a wide range of covariates of clinical significance. However, for fibrinogen, the association did not remain significant when waist circumference was entered in the final model. Our findings showed that 25(OH)D levels were associated with two out the three inflammatory markers investigated. The independent and inverse association between serum 25(OH)D levels and inflammation suggests a potential anti-inflammatory role for vitamin D in older English individuals from the general population

Modelling six sustainable development transformations in Australia and their accelerators, impediments, enablers, and interlinkages

There is an urgent need to accelerate progress on the Sustainable Development Goals (SDGs) and recent research has identified six critical transformations. It is important to demonstrate how these transformations could be practically accelerated in a national context and what their combined effects would be. Here we bridge national systems modelling with transformation storylines to provide an analysis of a Six Transformations Pathway for Australia. We explore important policies to accelerate progress, synergies and trade-offs, and conditions that determine policy success. We find that implementing policy packages to accelerate each transformation would boost performance on the SDGs by 2030 (+23% above the baseline). Policymakers can maximize transformation synergies through investments in energy decarbonization, resilience, social protection, and sustainable food systems, while managing trade-offs for income and employment. To overcome resistance to transformations, ambitious policy action will need to be underpinned by technological, social, and political enabling conditions

Subjective social status and mortality: the English Longitudinal Study of Ageing

Self-perceptions of own social position are potentially a key aspect of socioeconomic inequalities in health, but their association with mortality remains poorly understood. We examined whether subjective social status (SSS), a measure of the self-perceived element of social position, was associated with mortality and its role in the associations between objective socioeconomic position (SEP) measures and mortality. We used Cox regression to model the associations between SSS, objective SEP measures and mortality in a sample of 9972 people aged ≥ 50 years from the English Longitudinal Study of Ageing over a 10-year follow-up (2002-2013). Our findings indicate that SSS was associated with all-cause, cardiovascular, cancer and other mortality. A unit decrease in the 10-point continuous SSS measure increased by 24 and 8% the mortality risk of people aged 50-64 and ≥ 65 years, respectively, after adjustment for age, sex and marital status. The respective estimates for cardiovascular mortality were 36 and 11%. Adjustment for all covariates fully explained the association between SSS and cancer mortality, and partially the remaining associations. In people aged 50-64 years, SSS mediated to a varying extent the associations between objective SEP measures and all-cause mortality. In people aged ≥ 65 years, SSS mediated to a lesser extent these associations, and to some extent was associated with mortality independent of objective SEP measures. Nevertheless, in both age groups, wealth partially explained the association between SSS and mortality. In conclusion, SSS is a strong predictor of mortality at older ages, but its role in socioeconomic inequalities in mortality appears to be complex

Changes in vitamin D levels and depressive symptoms in later life in England

Inadequate vitamin D levels have been associated with increased risk of depression. However, most of these studies are cross-sectional and failed to investigate the effect of changes in vitamin D levels. This study aimed to investigate the longitudinal association of changes in serum 25-hydroxyvitamin D levels with depressive symptoms in 3365 participants of the English Longitudinal Study of Ageing, a large nationally-representative study of older adults. Based on their vitamin D levels at baseline and follow-up (sufficient ≥ 50 nmol/L; insufficient &lt; 50 nmol/L), participants were classified as follows: with sufficient levels at both waves; with sufficient levels at baseline but not at follow-up; with insufficient levels at baseline but ≥ 50 nmol/L at follow-up; and with levels &lt; 50 nmol/L at each time point. Depressive symptoms were measured using the 8-point CES-D scale. Data were analysed using logistic regression models. Compared with those with sufficient levels of vitamin D at both waves, only those with insufficient levels throughout were more likely to report elevated depressive symptoms (OR = 1.39, 95% CI = 1.00–1.93). Becoming or no longer being vitamin D deficient was, in the short term, not associated with elevated depressive symptoms. Further evidence is required on whether vitamin D supplementation might contribute to the prevention or treatment of depression as well as on the duration of time for changes in vitamin D levels to lead to detectable changes in depressive symptoms

Simulation of pollution transport in buildings: the importance of taking into account dynamic thermal effects

The recent introduction of the Generic Contaminant Model in EnergyPlus allows for the integrated modelling of multizone contaminant and dynamic thermal behaviour within a single simulation package. This article demonstrates how dynamic thermal simulation can modify pollutant transport within a building. PM2.5 infiltration from the external to internal environment under dynamic thermal conditions is compared in CONTAM, EnergyPlus 8.0, and Polluto, an in-house pollutant transport model developed in EnergyPlus 3.1. The influence of internal temperature on indoor PM2.5 levels is investigated by comparing results from standard CONTAM simulations and dynamic thermal EnergyPlus 8 simulations. Circumstances where the predictions of such models can diverge are identified

How solid is our knowledge of solid walls? - Comparing energy savings through three different methods

Recent UK-based studies have shown a performance gap between the energy performance of buildings calculated using tabulated thermophysical properties of solid walls and that estimated from in-situ measurements. Solid-walled buildings have been targeted by UK Government policies and incentive schemes to meet climate change mitigation targets and improve the efficiency of the building stock, as they are less efficient and more expensive to treat than cavity walls. Since it is common practice to estimate energy use and potential savings for buildings retrofit assuming standard values from the literature, the performance gap may have serious implications on the decision-making and the cost-effectiveness of energy-saving interventions. The aim of this paper is to compare and contrast the results obtained from three different methods for estimating normalised dwelling energy demand: a) the UK energy performance certificate (EPC) method, which uses the standard assessment procedure (SAP) with tabulated inputs (the business as usual case); b) the SAP calculated using empirical air change rates from pressure tests and U-values estimated analysing monitored data with a Bayesian-based dynamic method developed by the authors; c) a normalised annual consumption (NAC) method based on empirical energy consumption data from smart meter and weather data. The analysis is performed on a sample of dwellings from the Energy Saving Trust “Solid Wall Field Trials” dataset. Results show that EPC estimates are systematically higher (between 7.5% and 22.0%) than SAP. Conversely, the NAC displayed a large range of relative differences (between -77% and +99%) compared to the EPC. This raises questions about the relative merits and purpose of the EPC and SAP bottom up methods compared to the smart-meter data-driven NAC method. Further research is suggested using SAP 2009 to isolate the thermal component of energy demand and compare it directly with the NAC component

‘Hitting the target and missing the point’: Analysis of air permeability data for new UK dwellings and what it reveals about the testing procedure

Airtightness testing is widely undertaken to assess the as-built performance of dwellings, in support of achieving energy and ventilation strategies. Mandatory schemes operate in some countries, such as the UK, to ensure that dwellings are built in accordance with their design air permeability. However, testing is only useful if the results give a true picture of the airtightness of the building. Previous literature has investigated factors which could influence airtightness test results but has not questioned data quality, despite the pressure on builders to achieve design targets. This paper presents air permeability results from the largest UK dataset, comprising 144,024 dwellings tested under the Air Tightness Testing and Measurement Association (ATTMA) scheme. The data show an unexpected distribution of test results with narrow peaks just within test targets. Such results were not expected theoretically but do reflect findings in other fields where performance-based targets are in place. Such a close match between design and tested airtightness may be achieved by remedial works taking place during the test rather than afterwards. Recommendations are made with respect to quality assurance systems, design guidance and on-site sealing practices to increase the likelihood of long-term airtight buildings being constructed first time