Alternative routes to good jobs in the service economy: Employment restructuring and human resource management in incumbent telecommunications firms

This is a practitioner report detailing findings from a three-year study on organizational restructuring and employment outcomes at 10 incumbent telecommunications firms, supported by the Economic and Social Research Council. It presents background on markets, ownership, and institutions in the case study firms and countries, and compares restructuring policies in three areas: downsizing and employment adjustment; diversifying employment contracts; and work organization and human resource Management. The report concludes with policy recommendations, based on findings from the study.ESRC Grant RES-061-25-044

Institutions and Inequality in Liberalizing Markets: Explaining Different Trajectories of Institutional Change in Social Europe

Economic and Social Research Council [grant number RES-061-25-0444]

Not All Firms Are Created Equal: SMEs and Vocational Training in the UK, Italy, and Germany

Why do skill formation systems put SMEs at greater disadvantage in some countries than others vis-à-vis large employers? By comparing vocational education and training (VET) institutions and their differential effect on firms of different sizes across three countries (UK, Italy, and Germany), we show that the design of VET has profound implications for shaping the ability of SMEs to use institutions as resources. In particular, quasi-market institutions in the UK amplify SMEs’ disadvantage, while non-market coordinating institutions in Italy and Germany narrow the gap between SMEs and large employers. By unpacking the comparative disadvantage of SMEs, we offer important nuances to the argument that institutions help firms coordinate their business activities in different varieties of capitalism.Warum erfahren kleine und mittelständische Unternehmen (KMU) durch Berufsbildungssysteme mehr Nachteile als große Unternehmen und warum ist dieser Unterschied in manchen Ländern größer als in anderen? Wir vergleichen Ausbildungsinstitutionen und ihren unterschiedlichen Effekt auf Firmen verschiedener Größe in drei Ländern (Großbritannien, Italien und Deutschland). Dabei zeigen wir, dass die Art der Institutionen die Möglichkeit von Firmen, die vorhandenen Institutionen als Ressource zu nutzen, beeinflusst. Insbesondere verstärken die in Großbritannien vorherrschenden quasimarktlichen Institutionen den Nachteil von KMU, wohingegen nichtmarktliche Institutionen in Italien und Deutschland den Unterschied zu großen Unternehmen verringern. Durch das Aufzeigen des komparativen Nachteils von KMU leistet unser Papier einen Beitrag zu einer nuancierteren Sichtweise der Rolle von Institutionen in verschiedenen Spielarten des Kapitalismus.1 Introduction 2 Institutions, firms, and training 3 Puzzle and argument 4 Methodology 5 Findings The United Kingdom Italy Germany 6 Discussion and conclusion Appendix Reference

Effects of phase transitions in devices actuated by the electromagnetic vacuum force

We study the influence of the electromagnetic vacuum force on the behaviour of a model device based on materials, like germanium tellurides, that undergo fast and reversible metal-insulator transitions on passing from the crystalline to the amorphous phase. The calculations are performed at finite temperature and fully accounting for the behaviour of the material dielectric functions. The results show that the transition can be exploited to extend the distance and energy ranges under which the device can be operated without undergoing stiction phenomena. We discuss the approximation involved in adopting the Casimir expression in simulating nano- and micro- devices at finite temperature

Hypofractionated stereotactic radiotherapy in combination with whole brain radiotherapy for brain metastases

Background The efficacy and toxicity of hypofractionated stereotactic radiotherapy (HSRT) in combination with whole brain radiotherapy (WBRT), for the treatment of 1-4 brain metastases, using a non invasive fixation of the skull, was investigated. Methods Between 04/2001 and 01/2006 30 patients with 44 brain metastases underwent irradiation. Every patient received WBRT (10 x 3 Gy); 41/44 lesions received HSRT boost with a median dose fraction of 6 Gy, the fractionation schemes were 3 x 6 Gy and 4 x 8 Gy; a median total dose of 18 Gy was delivered to the tumor isocenter. Results The median survival period was 9.15 months, the actuarial 1-year overall survival and freedom from new brain metastases were 36.6% and 87.9%, respectively; at univariate analysis Karnofsky Performance Status (KPS) was statistically significant (P = 0.05); the actuarial 1-year local control for the 41/44 lesions was 86.1%. No patient had acute or late complications. Conclusions HSRT as a concomitant boost during WBRT is a safe and well tolerated treatment for selected patients with brain metastases

Mesenchymal stem cells for the treatment of psoriasis: a comprehensive review

Mesenchymal stem cells (MSCs) have recently been shown to have not only regenerative capabilities but also immunomodulating properties. For this reason, they are currently under investigation in clinical trials for the treatment of several autoimmune systemic disorders. Psoriasis is a systemic immune-mediated disease for which MSCs could have therapeutic potential. We analysed the existing literature with regard to MSC-based strategies for the treatment of psoriasis, using the MEDLINE, Embase, Scopus and Cochrane Library electronic databases from inception to the date of study. A number of studies confirm the involvement of MSCs in psoriasis pathogenesis and therefore designate MSCs as an important potential therapeutic tool in this setting. Preclinical data are mostly based on imiquimod-induced murine models of psoriasis, and confirm the anti-inflammatory and immunomodulatory action of MSCs in the setting of psoriasis. Six patients affected by psoriasis were described in four clinical studies. Despite significant differences in terms of therapeutic protocols and clinical outcomes, the MSC-based regimens were efficacious in 100% of the cases. Despite more data still being needed, MSCs could be a promising therapy for psoriasis

investigation of particle dynamics and classification mechanism in a spiral jet mill through computational fluid dynamics and discrete element methods

Abstract Predicting the outcome of jet-milling based on the knowledge of process parameters and starting material properties is a task still far from being accomplished. Given the technical difficulties in measuring thermodynamics, flow properties and particle statistics directly in the mills, modelling and simulations constitute alternative tools to gain insight in the process physics and many papers have been recently published on the subject. An ideal predictive simulation tool should combine the correct description of non-isothermal, compressible, high Mach number fluid flow, the correct particle-fluid and particle-particle interactions and the correct fracture mechanics of particle upon collisions but it is not currently available. In this paper we present our coupled CFD-DEM simulation results; while comparing them with the recent modelling and experimental works we will review the current understating of the jet-mill physics and particle classification. Subsequently we analyze the missing elements and the bottlenecks currently limiting the simulation technique as well as the possible ways to circumvent them towards a quantitative, predictive simulation of jet-milling

Mesenchymal stromal cells promote the proliferation of basal stem cells and efficient epithelization in organotypic models of wound healing

Adipose derived mesenchymal stromal cells (ADSCs) represent a fascinating tool in the scenario of wound healing and regenerative medicine. Recent data already demonstrated that ADSCs could exert a stimulatory action on epithelial cells through secretion of soluble factors. The aim of the present study was to assess how ADSCs guide wound re-epithelization in vitro in the presence of keratinocytes. We used an organotypic model of wound healing and we seeded keratinocytes on a ADSC-induced dermal matrix. Conventional hematoxylin–eosin stain and immunohistochemistry staining for Ki67, p63 and pan-keratins were performed at different timepoints. Histological sections of organotypic cultures showed complete coverage of the ADSC-induced matrix by keratinocytes. Proliferation of basal stem cells was found to be the main mechanism responsible for epithelization of the dermis. In conclusion, ADSC do not only stimulate dermal regeneration through collagen deposition but also promote epithelization