Patient's breath controls comfort devices

Patient assist system for totally disabled persons was developed which permits a person, so paralyzed as to be unable to move, to activate by breathing, a call system to summon assistance, turn the page of a book, ajust his bed, or do any one of a number of other things. System consists of patient assist control and breath actuated switch

The influence of normal stress and sliding velocity on the frictional behaviour of calcite at room temperature. Insights from laboratory experiments and microstructural observations

The presence of calcite in and near faults, as the dominant material, cement, or vein fill, indicates that the mechanical behaviour of carbonate-dominated material likely plays an important role in shallow- and mid-crustal faulting. To better understand the behaviour of calcite, under loading conditions relevant to earthquake nucleation, we sheared powdered gouge of Carrara Marble, >98 per cent CaCO3, at constant normal stresses between 1 and 100 MPa under water-saturated conditions at room temperature. We performed slide-hold-slide tests, 1–3000 s, to measure the amount of static frictional strengthening and creep relaxation, and velocity-stepping tests, 0.1–1000 µm s–1, to evaluate frictional stability. We observe that the rates of frictional strengthening and creep relaxation decrease with increasing normal stress and diverge as shear velocity is increased from 1 to 3000 µm s–1 during slide-hold-slide experiments. We also observe complex frictional stability behaviour that depends on both normal stress and shearing velocity. At normal stresses less than 20 MPa, we observe predominantly velocity-neutral friction behaviour. Above 20 MPa, we observe strong velocity-strengthening frictional behaviour at low velocities, which then evolves towards velocity-weakening friction behaviour at high velocities. Microstructural analyses of recovered samples highlight a variety of deformation mechanisms including grain size reduction and localization, folding of calcite grains and fluid-assisted diffusion mass transfer processes promoting the development of calcite nanograins in the highly deformed portions of the experimental fault. Our combined analyses indicate that calcite fault gouge transitions from brittle to semi-brittle behaviour at high normal stress and slow sliding velocities. This transition has important implications for earthquake nucleation and propagation on faults in carbonate-dominated lithologies

Blood transfusion effects in kidney transplantation.

Within the three decades since the beginnings of the field of clinical renal transplantation there have been four phases in blood transfusion policies, swinging from liberal transfusions to avoidance of transfusions, followed by a repeat cycle of deliberate transfusions and at present turning back to abstinence again. Because of improving skills at the prevention and treatment of rejections, the beneficial effects of random transfusions in the transplant population as a whole is marginal. This comes at a time when community fears of blood-borne infections and the prospects of supporting red cell production by the use of EPO have emerged as new factors in blood banking. Observations on patients at risk for graft loss, namely those having rejection episodes, indicate that a beneficial blood transfusion effect still exists, however. Future application of deliberate HLA antigen exposure in conjunction with novel immunological manipulations may provide a more effective avenue to tolerance induction. The use of blood transfusions matched for one HLA-DR antigen with the recipient has produced major benefits in preliminary trials and represents one starting point in this direction

Negative Cell Cycle Regulation and DNA Damage-inducible Phosphorylation of the BRCT Protein 53BP1

In a screen designed to discover suppressors of mitotic catastrophe, we identified the Xenopus ortholog of 53BP1 (X53BP1), a BRCT protein previously identified in humans through its ability to bind the p53 tumor suppressor. X53BP1 transcripts are highly expressed in ovaries, and the protein interacts with Xp53 throughout the cell cycle in embryonic extracts. However, no interaction between X53BP1 and Xp53 can be detected in somatic cells, suggesting that the association between the two proteins may be developmentally regulated. X53BP1 is modified via phosphorylation in a DNA damage-dependent manner that correlates with the dispersal of X53BP1 into multiple foci throughout the nucleus in somatic cells. Thus, X53BP1 can be classified as a novel participant in the DNA damage response pathway. We demonstrate that X53BP1 and its human ortholog can serve as good substrates in vitro as well as in vivo for the ATM kinase. Collectively, our results reveal that 53BP1 plays an important role in the checkpoint response to DNA damage, possibly in collaboration with ATM

NICMOS2 hubble space telescope observations of the embedded cluster associated with Mon R2: Constraining the substellar initial mass function

We have analyzed Hubble Space Telescope NICMOS2 F110W-, F160W-, F165M-, and F207M-band images covering the central 1' × 1' region of the cluster associated with Mon R2 in order to constrain the initial mass function (IMF) down to 20M_J. The flux ratio between the F165M and F160W bands was used to measure the strength of the water-band absorption feature and select a sample of 12 out of the total sample of 181 objects that have effective temperatures between 2700 and 3300 K. These objects are placed in the H-R diagram together with sources observed by Carpenter et al. to estimate an age of ~1 Myr for the low-mass cluster population. By constructing extinction-limited samples, we are able to constrain the IMF and the fraction of stars with a circumstellar disk in a sample that is 90% complete for both high- and low-mass objects. For stars with estimated masses between 0.1 and 1.0 M_☉ for a 1 Myr population with A_V ≤ 19 mag, we find that 27% ± 9% have a near-infrared excess indicative of a circumstellar disk. The derived fraction is similar to or slightly lower than the fraction found in other star-forming regions of comparable age. We constrain the number of stars in the mass interval 0.08-1.0 M_☉ to the number of objects in the mass interval 0.02-0.08 M_☉ by forming the ratio R^(**) = N(0.08-1 M_☉)/N(0.02-0.08 M_☉) for objects in an extinction-limited sample complete for A_V ≤ 7 mag. The ratio is found to be R^(**) = 2.2 ± 1.3, assuming an age of 1 Myr, consistent with the similar ratio predicted by the system IMF proposed by Chabrier. The ratio is similar to the ratios observed toward the Orion Nebula Cluster and IC 348, as well as the ratio derived in the 28 deg^2 survey of Taurus by Guieu et al

Antigenic determinants of tubular basement membranes and Bowman's capsule in rats

Antigenic determinants of tubular basement membranes and Bowman's capsule in rats. Kidney sections from several inbred rat strains were studied with an indirect immunofluorescence technique using five different, selected rat antisera which contained antibodies against the tubular basement membrane (TBM). The sera came from transplanted animals, an apparently normal animal, and animals treated with spleen cells in complete Freund's adjuvant. Upon panel analysis, at least two different antigenic determinants were recognized on the proximal TBM: One was present in nine and one was present in seven of the 15 strains tested; both determinants appear to be expressed in most antigen-positive strains. Using kidneys from major histocompatibility complex (MHC)-congenic strains, it was shown that the TBM antigens are encoded outside the MHC region. Three sera produced variable staining of Bowman's capsule in association with the proximal TBM; two sera produced clearly discordant staining of Bowman's capsule and proximal TBM. The capsular antigens were also coded outside the MHC region. These observations suggested the existence of at least two different antigenic determinants on proximal TBM. Bowman's capsule appeared to have antigenic determinants in common with the proximal TBM as well as distinct determinants.Déterminants antigéniques des membranes basales tubulaires et de la capsule de Bowman du rat. Des sections de rein de plusieurs souches pures de rats étaient étudié par une technique d'immunofluorescence indirecte utilisant cinq anti-sérums de rats différents, sélectionnés, contenant des anticorps contre la membrane basale tubulaire (MBT). Les sérums provenaient d'animaux transplantés, d'un animal en apparence normal, et d'animaux traités avec des cellules spléniques dans de l'adjuvant complet de Freund. En faisant une analyse globale, au moins deux déterminants antigéniques différents étaient reconnus dans les MBT proximales. L'un était présent chez neuf, l'autre chez sept des quinze souches testées; les deux déterminants antigéniques semblaient exprimés chez la plupart des souches antigène positif. En employant des reins provenant de souches complexe de histocompatibilité majeur (CHM)-congéniques, nous avons montré que les antigènes de la MBT sont codés à l'extérieur de la région MHC. Trois sérums ont produit une coloration variable de la capsule de Bowman en plus des MBT proximales; deux sérums ont produit des colorations nettement discordantes de la capsule de Bowman et des MTB proximales. Les antigènes capsulaires ont également codés à l'extérieur de la région MHC. Ces observations suggèrent l'existence d'au moins deux déterminants antigéniques différents dans les MTB proximales. La capsule de Bowman sembla avoir des déterminants antigéniques communs avec les MTB proximales, mais également des déterminants différents

The synthesis of 15 mu infrared horizon radiance profiles from meteorological data inputs

Computational computer program for modeling infrared horizon radiance profile using pressure and temperature profile input