Cochlear Damage Affects Neurotransmitter Chemistry in the Central Auditory System

Tinnitus, the perception of a monotonous sound not actually present in the environment, affects nearly 20% of the population of the United States. Although there has been great progress in tinnitus research over the past 25 years, the neurochemical basis of tinnitus is still poorly understood. We review current research about the effects of various types of cochlear damage on the neurotransmitter chemistry in the central auditory system and document evidence that different changes in this chemistry can underlie similar behaviorally measured tinnitus symptoms. Most available data have been obtained from rodents following cochlear damage produced by cochlear ablation, loud sound, or ototoxic drugs. Effects on neurotransmitter systems have been measured as changes in neurotransmitter level, synthesis, release, uptake, and receptors. In this review, magnitudes of changes are presented for neurotransmitter-related amino acids, acetylcholine, and serotonin. A variety of effects have been found in these studies that may be related to animal model, survival time, type of cochlear damage, or methodology. The overall impression from the evidence presented is that any imbalance of neurotransmitter-related chemistry could disrupt auditory processing in such a way as to produce tinnitus

Internalizing symptomatology and academic achievement: bi-directional prospective relations in adolescence

Prior research has documented negative, concurrent relations between internalizing symptomatology and academic achievement among adolescents. The present study provided the first rigorous, longitudinal examination of the bi-directional, prospective relations between adolescent internalizing symptomatology and academic achievement. One hundred and thirty adolescents reported depression and anxiety annually from 6th through 10th grades, and GPA records were obtained annually from schools. Results showed that a) high depression and anxiety at the beginning of a school year predicted lower GPA during that school year, and b) low GPA in any school year predicted higher depression and anxiety at the beginning of the following school year. These findings underscore the tight link between adolescent internalizing symptomatology and academic achievement

Toxicological Indices of Wistar Rats Fed Formulated Chaw of Telfairia occidentalis Planted on Crude Oil Contaminated and Remediated Soil

Toxicological indices of wistar rats fed formulated chaw of Telfairia occidentalis planted on crude oil contaminated and bioremediated soil was studied. Farmland, measuring 18 m2 was divided into three lots of 4 m2 and 2 m space was allowed between each lot (A, B and C). Two lots were polluted, subjected to 16 weeks of bioremediation and viable seeds of T. occidentalis were planted and grown for 28 days. The harvested vegetable leaves were analyzed. Leaves from natural attenuated soil showed high concentration of both aliphatic and polycyclic aromatic hydrocarbons with values of 9.34+0.03 mg/kg and 9.18+0.05 mg/kg for C36 and Fluoranthene respectively, while the bioaugmented soil had Lead as the highest heavy metal with a value of 0.10+0.02 g/100g. Four groups, of 9 rats each (totalling 36 rats) of adult males and females, wealing males and females were subsequently sub-grouped into 3 and allowed to acclimatize for a period of 1 week. These animals were fed formulated rat chaw of 50% dry weight of T. occidentalis, from the three lots (control, bioaugmented and natural attenuated soil) for a period of 28 days. Assay of animals’ toxicological index showed elevated concentrations of alkaline phosphatase, alanine and aspartate aminotransferases, urea and creatinine in their sera. A slight increase in serum amylase activity was recorded, while concentrations of their haemoglobin and Packed Cell Volume (PCV) reduced. The obtained results from these biomarkers were confirmed by the histopathological sections of the animal organs

Hepatoprotective effect of an aqueous extract of the leaves of Acalypha wilkesiana 'Godseffiana' Muell Arg (Euphorbiaceae) against carbon tetrachloride induced liver injury in rats

The potential of aqueous extract of the leaves of Acalypha wilkesiana, to protect against carbon tetrachloride induced liver damage was investigated in Wistar albino rats. The carbon tetrachloride was prepared 1:5 (v:v) in olive oil, and administered subcutaneously at 1 mL/kg body weight. The extract was administered to both normal and carbon tetrachloride treated rats at 100, 200 and 300 mg/kg. On fractionation and gas chromatographic analysis of the crude aqueous extract, thirty nine known alkaloids were detected, consisting mainly of akuamidine (69.027 %), voacangine (26.226 %), echitamine (1.974 %), echitamidine (0.599 %), lupanine (0.521 %) and augustamine (0.278 %). Compared to test control, the treatment dose dependently produced significantly lower (P<0.05) alkaline phosphatase, aspartate and alanine transaminase activities. Histopathological studies on the liver sections showed that pre-treatment with the extract protected against carbon tetrachloride induced fatty degeneration of hepatocytes, thus, confirming the results of the biochemical studies. The above results imply that treatment with the plant extract protects the liver against carbon tetrachloride induced hepatotoxicity, therefore, justifying the use of Acalypha wilkesiana in African traditional health care for the management of liver problems

Ultrasound Findings in the Gallbladder of Sickle‑Cell Patients: A Cross‑Sectional Study in Enugu, Nigeria

Background: Sickle‑cell disease (SCD) causes chronic and recurrent hemolysis which is a recognized risk factor for gallbladder (GB) disease. The prevalence of GB disease in SCD is high and increases with age. Cholelithiasis and cholecystitis are relatively common GB diseases in SCD. They are important causes of acute abdominal pain in SCD and also increase morbidity. Ultrasound is a cheap and noninvasive means of evaluating the GB; it has a high degree of accuracy and is widely available. Aims: The aim of this study is to sonographically evaluate the GB of SCD patients in steady state at the University of Nigeria Teaching Hospital (UNTH), Ituku‑Ozalla, Enugu, and to determine the prevalence of specific GB diseases in SCD patients. Materials and Methods: A prospective cross‑sectional study of 130 known SCD patients attending sickle‑cell clinics at UNTH and 130 controls. Ultrasound of the GB was done after at least 6 h fast, using a Dp2200 mindray mobile ultrasound machine equipped with a 2.5–5 MHz convex probe. The data were analyzed using the SPSS software version 16. Results: The GBs of 130 consecutive SCD participants and 130 control group were sonographically evaluated. The prevalence of cholelithiasis in SCD was 10.8%, whereas the prevalence of cholelithiasis in the control group was 3.1%. No other GB diseases were seen. The mean dimensions of theGB for the study group were length (65.78 ± 9.85 mm), width (29.15 ± 6.01 mm), depth (25.58 ± 5.81 mm), wall thickness (1.59 ± 0.74 mm), and volume (26.52 ± 11.18 cm3). Conclusion: The prevalence of cholelithiasis in sickle cell disease in southeast Nigeria is 10.8% while the prevalence of cholelithiasis in the control population is 3.1%. Keywords: Cholecystitis, cholelithiasis, gallbladder, sickle cell disease, ultrasoun

‘Pseudopneumothorax’—Hold that chest tube!

We report a case of herniation of abdominal contents into the left hemithorax in a patient with a history of vague left-sided thoracoabdominal trauma 18 days previous to admission and who also had a recent 1-week history of upper respiratory symptoms, including cough, and then presented with dyspnoea and fever for 3 days. There was no preceding cardiorespiratory pathology of note. We also discuss the epidemiology, pathogenesis and management of blunt-traumatic diaphragmatic rupture

INFLUENCE OF LIBRARIANS ATTITUDE TOWARD CATALOGUING AND CLASSIFICATION IN ACADEMIC LIBRARIES

This study investigated the influence of librarians’ attitude toward cataloguing and classification in academic libraries. Academic library is the heartbeat of a higher institution of learning. Without an academic library, students, researchers, staff might find it very difficult to study and conduct effective and efficient research. All information resources in academic libraries are expected to be catalogued and classified by librarians/cataloguers with standard classification schemes which would bring all the related books together. The attitude of librarians toward cataloguing and classification can be positive or negative. Positive in the essence that they tend to enjoy or like cataloguing and classification, understand its value, and have confidence in it. However, librarians with a negative attitude toward cataloguing and classification tend to dislike it, and feel afraid to engage in it. The attitude of librarians toward cataloguing and classification would be determined whether the library information resources in the academic libraries would be catalogued or not. If librarians develop a positive attitude toward cataloguing and classification, all the library information resources in an academic library would be catalogued, classified, organized, arranged and shelved in order for the library users to make use of them. But if librarians develop a negative attitude toward cataloguing and classification, some of library information resources might not be catalogued or wrongly catalogued where they would not be useful for the users

Prognostic values of adiponectin and leptin in assessment of osteoarthritis in menopausal HIV women in Nauth Nnewi Nigeria

Background: Human immune deficiency virus (HIV) has progressively been implicated with development of inflammatory disease including osteoarthritis. This study evaluated serum levels of adiponectin and leptin in women living with HIV with/without osteoarthritis who have been placed on highly active anti-retroviral therapy (HAART) in NAUTH, Nnewi, Nigeria. Methods: Eighty eight participants aged between 18 and 65 years attending HAART unit of NAUTH, Nnewi were randomly selected and grouped thus: Group A (premenopausal HIV seropositive women with osteoarthritis), group B (postmenopausal HIV seropositive women with osteoarthritis), group C (premenopausal HIV seropositive women) and group D (postmenopausal HIV seropositive women). Five milliliters of blood sample collected from each of participants for determination of adiponectin and leptin using enzyme linked immunosorbent assay (ELISA) technique. Results: Adiponectin level was significantly higher in postmenopausal HIV seropositive women with osteoarthritis compared with pre and postmenopausal HIV seropositive women without osteoarthritis (p&lt;0.05 respectively). Similarly, leptin level was significantly higher in pre and post-menopausal HIV seropositive women with osteoartritis compared with their counterparts without osteoarthritis (p&lt;0.05 respectively). A positive significant correlation was observed between Leptin and age in premenopausal HIV seropositive women with osteoarthritis. Also, a significant negative correlation was observed between adiponectin, age in pre and postmenopausal HIV seropositive women without osteoarthritis. Conclusions: The significant increases in adiponectin and leptin levels in pre and postmenopausal HIV seropositive women can be linked to severe inflammatory reaction due to osteoarthritis which might have been aggravated by combined effects of menopause and HIV infection

Innovative use of tourniquet in the management of an advanced abdominal pregnancy to achieve an unusually normal postoperative outcome: a case report

Mrs. UVG was an un-booked G3P1+1 petty trader, who presented with an obstetric ultrasound scan report, with an incidental diagnosis of abdominal pregnancy at 32 weeks of gestation with the placenta attached to the fundus of the uterus. Her admission packed cell volume was 24%. She had pre-operative preparation and 2 units of compatible blood were transfused to correct the anemia. Four additional units of compatible blood were made available before she was scheduled for an exploratory laparotomy at 33 weeks of gestation. A grossly normal male infant weighing 2.2 kg was delivered from the peritoneal cavity with Apgar scores of 2 at 1 minute and the same at 5 minutes. The placenta which was attached to the fundus of the uterus was removed manually completely after a tourniquet had been applied distal to the point of separation. Intra-operative blood loss was 1000 ml. The infant died 1 hour after delivery due to respiratory failure. Autopsy report revealed massive intracerebral hemorrhage and pulmonary hypoplasia. The post-operative period was uneventful and the decline in serum assay of β-human chorionic gonadotrophin postpartum was normal. She was discharged home on the 8th post-operative day and seen at the postnatal clinic twice at weekly intervals with normal serum assay of β-human chorionic gonadotrophin. Her 6 weeks postnatal visit was also uneventful