Comparison of selected startup ecosystems in Germany and in the USA Explorative analysis of the startup environments

The startup ecosystems in Germany and in the US aredifferent in several dimensions and they have a huge impact onthe success of startups. In this study the factors that affects thestartup ecosystems are compared. It is analyzed what startupsconsider as critical to their success and how this varies based onthe location of the startups. Using the developed scoringmechanism, the study compares the relative scores of varioussuccess factors between the German and American startups toidentify areas for improvement. The findings suggest thatGermany is successful in implementing co-working spaces andincubators but it lacks on accelerator programs. Further, it needsto develop a better support system for their startups while theGerman startups themselves need to focus on building a strongerinternal team in order to boost the startup ecosystem

IOT Based Intelligent Bin for Smart Cities

The method of connecting the objects or things through wireless connectivity, Internet called Internet Of Things. Nowadays a variety of tasks are based on IOT. Cities in the world are becoming smarter by implementing the things around using IOT. This is a new trend in technology. Smart cities include obstacle tracking, object sensing, traffic control, tracking of our activities, examining the baby, monitoring home lights and so on. One of the objective of smart cities is keeping the environment clean and neat. This aim is not fulfilled without the garbage bin management system. Hence the paper “IOT Based Intelligent Bin for Smart Cities” has been developed. Bin management is one of the major applications of IOT. Here sensors are connected to the all the bins at different areas. It senses the level of garbage in bin. When it reaches threshold a message is sent via GSM to the concerned person to clean it as soon as possible. The completed task is done in LabVIEW environment

Laparoscopic management of an endometrioma complicated by an ovarian abscess

An ovarian abscess is defined as a primary infection of the ovary without the involvement of the fallopian tube. The possible factors for the cause of ovarian abscess are: disruption of the ovarian capsule, giving access to bacteria, haematogenous and lymphatic spread. A woman with a ruptured ovarian abscess presents with features of diffuse peritonitis. An unruptured abscess is more difficult to diagnose. Unruptured abscess can be dealt with either laparotomy or laparoscopy. Ruptured ovarian abscess requires an aggressive and primarily surgical approach.

β-cyclodextrin-enzalutamide self-assembly complexes for prostate cancer therapy

Background:Castrate circumstances brought on by therapy give rise to castrationresistant prostate cancer (CRPC), which thereafter develops androgen receptor (AR) resistance. AR inhibitors are frequently used to obstruct AR translocation in cells that overexpress AR and slow the progression of cancer by reducing the number of AR receptors that are accessible. In comparison to Bicalutamide, a first-generation AR inhibitor, the hydrophobic drug Enzalutamide has demonstrated higher effectiveness. We investigate Enzalutamide as a viable option for the formation of self-assembly complexes because AR downregulation is still the major treatment for CRPC. Methods:Enz-loaded self-assembly complexes (enz-β-CD) formulation was developed using solvent evaporatin method utilizing β-cyclodextrin (β-CD) as a solubilizer, which has a welldocumented safety profile and FDA approval. The inclusion complex formation has been confirmed from dynamic light scattering (DLS), Fourier-transformed infrared spectroscopy (FTIR), scanning electron microscopy (SEM), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), and nuclear magnetic resonance (NMR) spectral analysis, respectively. The cellular internalization capacity of this formulation was evaluated using flow cytometry and fluorescent microscopy. The therapeutic efficacy of enz-β-CD self-assembly complexes was evaluated using clinically relevant PC cell lines (C4-2B, and 22-RV1) through cell proliferation and colony formation assays. Caco2 permiability assay was used to test the suitability of compound for oral dosing. Results: Our DLS, DSC, XRD, FTIR, and NMR studies demonstrated that Enz was entrapped in the inner cavity of β-CD, and the inclusion complex formed in an amorphous state. The particle size of the inclusion complex was found less than 100 nm, while zeta potential and PDI were −7.6 mV and 0.2, respectively. Moreover, inclusion complexes have the characteristic structure of an adduct, in which one compound (Enz) guest molecule, is enclosed to the host molecule i.e. β-CD. Interestingly the guest molecule is situated in the cavity of the host without significantly affecting the host framework structure. The flow cytometry and fluorescence microscopy analysis confirmed a dose-dependant cellular uptake in PC cells. The CCK-8 assay confirms that enz-β-CD self-assembly complexes exhibited anticancer effects in C42B and 22RV1 cells, like bare Enz. A similar clonogenic potential was noticed with the enz-β-CD selfassembly complexes.The permeability assay showed the drug efflux that would allow for intestinal permiability of the drug. Conclusions: Based on our findings, the free medication does not possess the Enz-Beta cyclodextrin formulation\u27s improved anti-cancer characteristics. For the successful therapy of castrationresistant prostate cancer (CRPC), this new inclusion complex shows promise

Advice to clinicians on communication from adolescents and young adults with cancer and parents of children with cancer

Effective communication is integral to patient and family-centered care in pediatric and adolescent and young adult (AYA) oncology and improving healthcare delivery and outcomes. There is limited knowledge about whether AYAs and parents have similar communication preferences and needs. By eliciting and comparing communication advice from AYAs and parents, we can identify salient guidance for how clinicians can better communicate. We performed secondary analysis of semi-structured interviews from 2 qualitative communication studies. In one study, 80 parents of children with cancer during treatment, survivorship, or bereavement were interviewed. In the second study, AYAs with cancer during treatment or survivorship were interviewed. We asked AYAs and parents to provide communication advice for oncology clinicians. Using thematic analysis, we identified categories of advice related to three overarching themes: interpersonal relationships, informational preferences, and delivery of treatment, resources, and medical care. AYAs and parents provided similar advice about the need for compassion, strong connections, hopefulness, commitment, and transparent honesty However, AYAs placed additional emphasis on clinicians maintaining a calm demeanor

MATLAB Based Realtime Face Recognition for Attendance Monitoring using PCA

Face acknowledgment is a testing issue because of variety in demeanor, posture, brightening and maturing and so on. The presented paper basically deals with the working of face recognition system using Principal Component analysis (PCA). PCA is a quantifiable approach used for diminishing the quantity of factors in confront acknowledgement. In PCA, each photo in the planning set is considered as an immediate mix of weighted eigenvectors called eigenfaces. These eigenvectors are obtained from covariance lattice of an arrangement picture set. The weights are found in the way of picking a game plan of most noteworthy Eigenfaces. Affirmation is done by anticipating a test picture onto the subspace crossed by the eigenfaces and after that course of action is done by assessing the minimum Euclidean division

Development of liposomes using microfluids for delivery of miR-205

Background: The therapeutic application of microRNA(s) in the field of cancer has generated significant attention in research. miR-205 is a tumor suppressor in various cancers. However, the delivery of miR-205 is an unmet clinical need. Thus, the development of liposomal formulation platform to deliver miR-205 is highly sought. The most common applications of liposome formulations are vaccines and anticancer formulations (e.g., mRNA, small molecule drugs). However, large-scale production with precise control of size and size distribution of the lipid-based drug delivery systems (DDSs) is one of the major challenges in the pharmaceutical industry. The objective of this study is to develop liposomal formulation with precise size and optimal for delivery of miR-205. Methods: Microfluidics chip designed based on commercial microfluidic device platform was employed for preparation of liposomes. The device is set for the synthesis of liposome at total flow rate (FRR) 10 ml min−1 and 1:3 flow rate ratio (TFR). To determine the optimal conditions, the effect of different factors including FRR, TFR, and total lipid concentration (lipid and cholesterol) on particle size and size distribution is investigated. Liposomes are also produced by a bulk method to compare the properties of the liposomes formed through these methods. The obtained formulations were tested to analyses different physiochemical properties (DLS, FTIR, DSC, and TGA), stability studies and optimized liposomal formulation was confirmed by examining the intracellular accumulation. Results: All formulations displayed an average size less than 200 nm and exhibited acceptable physicochemical behavior. This design demonstrated high productivity and better control of liposome size and polydispersity index (PDI) than conventional liposome preparation methods. The microfluidic devices were used to produce miR-205-loaded liposomes under different processing conditions which were later characterized and studied in vitro to evaluate their efficiency as a drug delivery system. Conclusions: The obtained results demonstrated that the liposomes can effectively deliver miR-205 into cancer cells. Therefore, the microfluidic devices platform are promising devices for reproducible and scalable manufacturing of liposomal formulation

Prognostic Role of Serum Chloride Levels in Acute Decompensated Heart Failure

BACKGROUND: Acute decompensated heart failure (ADHF) can be complicated by electrolyte abnormalities, but the major focus has been concentrated on the clinical significance of serum sodium levels