Contemporary Russian liberalism

This article analyzes contemporary Russian liberalism through the prism of competing trends of moderate pluralist and monistic radical thought. The author focuses particularly on the pluralist trend, less well known in the West, arguing that its prospects are more promising over the long term. Ideological and tactical differences within the liberal camp in Russia are compared with those in the West, both for the purpose of emphasizing that such differences are not unique to Russia and to show the connections between Russian and Western strands of liberal political thought

Bimodal Magnetic and Fluorescent Nanoparticles for Biomedical Applications

The study was carried out with the financial support of the Russian Foundation for Basic Research in the framework of the research project № 18-33-00785) as well as with the help of the complex program of the Ural Branch of the Russian Academy of Sciences project № 18-10-2-5

Competing ideologies of Russia's civil society

Many analysts and public opinion makers in the West conflate the notions of Russia’s non-systemic liberal opposition and the country’s civil society. Indeed, despite garnering the support of a minority of Russia’s population, non-systemic liberal opposition represents a well-organized civic group with a clearly articulated agenda and the ability to take action. Yet, does Russia’s civil society end there? A closer look at the country’s politics shows that Russia has a substantial conservative-traditionalist faction that has also developed agenda for action and formulated opinions. This group is anti-liberal rather than illiberal ideologically and pro-strong state/pro a geopolitically independent Russia rather than pro-Kremlin politically. The interaction between liberal and conservative civic groups represents the battle of meanings, ideas, and ethics, and ultimately determines the future trajectory of Russia’s evolution. Thus, the analysis of Russia’s civil society must represent a rather more nuanced picture than a mere study of the liberal non-systemic opposition. This article will examine the complexity of Russia’s civil society scene with reference to the interplay between the liberal opposition and conservative majority factions. The paper will argue that such complexity stems from ideological value pluralism that falls far beyond the boundaries of the liberal consensus, often skewing our understanding of political practice in Russia

Species-Specific Effects of Epigeic Earthworms on Microbial Community Structure during First Stages of Decomposition of Organic Matter

Background: Epigeic earthworms are key organisms in organic matter decomposition because of the interactions they establish with microorganisms. The earthworm species and the quality and/or substrate availability are expected to be major factors influencing the outcome of these interactions. Here we tested whether and to what extent the epigeic earthworms Eisenia andrei, Eisenia fetida and Perionyx excavatus, widely used in vermicomposting, are capable of altering the microbiological properties of fresh organic matter in the short-term. We also questioned if the earthworm-induced modifications to the microbial communities are dependent on the type of substrate ingested. Methodology/Principal Findings: To address these questions we determined the microbial community structure (phospholipid fatty acid profiles) and microbial activity (basal respiration and microbial growth rates) of three types of animal manure (cow, horse and rabbit) that differed in microbial composition, after being processed by each species of earthworm for one month. No differences were found between earthworm-worked samples with regards to microbial community structure, irrespective of type of manure, which suggests the existence of a bottleneck effect of worm digestion on microbial populations of the original material consumed. Moreover, in mesocosms containing cow manure the presence of E. andrei resulted not only in a decrease in bacterial and fungal biomass, but also in a reduced bacterial growth rate and total microbial activity, while no such reduction was found with E. fetida and P. excavatus

Позднекайнозойское разломообразование и напряженное состояние юго-восточной части Сибирской платформы

We have studied the structural geology and geomorphology of the fault zones in the junction area of the Angara-Lena uplift and the Predbaikalsky trough. We have analyzed faults and folds and reconstructed paleostresses for this junction area named the Irkutsk amphitheatre. Our study shows that syn-fold (Middle Paleozoic) faults include thrusts, reverse faults and strike-slip faults with reverse components, that occurred due to compression from the neighbouring folded region. Recently, contrary to compression, faulting took place under the conditions of extension of the sedimentary cover: most of these recent faults have been classified as normal faults. In the Late Cenozoic, the platform cover was subjected to brittle and partly plicative deformation due to the NW–SE-trending extension that is most clearly observed in the adjacent Baikal rift. Thus, the divergent boundary between the Siberian block of the North Eurasian plate and the Transbaikalia block of the Amur plate is a zone of dynamic influence, which occupies the area considerably exceeding the mountainous region on the Siberian platform. Important factors of faulting are differentiated vertical movements of the blocks comprising the platform. Such vertical movements might have been related to displacements of brine volumes. In the Late Cenozoic basins, movements along separate faults took place in the Late Pleistocene – Holocene.Проведены геолого-структурные и геоморфологические исследования зон разломов восточной части Иркутского амфитеатра – зоны сочленения Ангаро-Ленского поднятия и Предбайкальского прогиба. Анализ парагенезов разрывов, складок и реконструкции палеостресса показали, что синскладчатые (среднепалеозойские) разломы представлены надвигами, взбросами и взбросо-сдвигами, сформированными при воздействии сжатия со стороны сопредельной складчатой области. Формирование разломов в новейшее время, напротив, происходило в условиях растяжения осадочного чехла. Разломы этого этапа представлены главным образом сбросами. Хрупкие и, частично, пликативные деформации чехла платформы в позднем кайнозое происходили в условиях растяжения СЗ–ЮВ направления, наиболее ярко выраженного в соседнем Байкальском рифте. Зона динамического влияния дивергентной границы между Сибирским блоком Северо-Евразийской плиты и Забайкальским блоком Амурской плиты, таким образом, простирается внутрь платформы далеко за границы горной области. Важным фактором формирования разломов являются дифференцированные вертикальные движения блоков платформы, в происхождении которых могли участвовать процессы перетекания солевых толщ. В позднекайнозойских впадинах движения по отдельным разломам происходили в позднем плейстоцене – голоцене

Synaptic Transmission from Horizontal Cells to Cones Is Impaired by Loss of Connexin Hemichannels

In the vertebrate retina, horizontal cells generate the inhibitory surround of bipolar cells, an essential step in contrast enhancement. For the last decades, the mechanism involved in this inhibitory synaptic pathway has been a major controversy in retinal research. One hypothesis suggests that connexin hemichannels mediate this negative feedback signal; another suggests that feedback is mediated by protons. Mutant zebrafish were generated that lack connexin 55.5 hemichannels in horizontal cells. Whole cell voltage clamp recordings were made from isolated horizontal cells and cones in flat mount retinas. Light-induced feedback from horizontal cells to cones was reduced in mutants. A reduction of feedback was also found when horizontal cells were pharmacologically hyperpolarized but was absent when they were pharmacologically depolarized. Hemichannel currents in isolated horizontal cells showed a similar behavior. The hyperpolarization-induced hemichannel current was strongly reduced in the mutants while the depolarization-induced hemichannel current was not. Intracellular recordings were made from horizontal cells. Consistent with impaired feedback in the mutant, spectral opponent responses in horizontal cells were diminished in these animals. A behavioral assay revealed a lower contrast-sensitivity, illustrating the role of the horizontal cell to cone feedback pathway in contrast enhancement. Model simulations showed that the observed modifications of feedback can be accounted for by an ephaptic mechanism. A model for feedback, in which the number of connexin hemichannels is reduced to about 40%, fully predicts the specific asymmetric modification of feedback. To our knowledge, this is the first successful genetic interference in the feedback pathway from horizontal cells to cones. It provides direct evidence for an unconventional role of connexin hemichannels in the inhibitory synapse between horizontal cells and cones. This is an important step in resolving a long-standing debate about the unusual form of (ephaptic) synaptic transmission between horizontal cells and cones in the vertebrate retina

A Positive Feedback Synapse from Retinal Horizontal Cells to Cone Photoreceptors

Cone photoreceptors and horizontal cells (HCs) have a reciprocal synapse that underlies lateral inhibition and establishes the antagonistic center-surround organization of the visual system. Cones transmit to HCs through an excitatory synapse and HCs feed back to cones through an inhibitory synapse. Here we report that HCs also transmit to cone terminals a positive feedback signal that elevates intracellular Ca2+ and accelerates neurotransmitter release. Positive and negative feedback are both initiated by AMPA receptors on HCs, but positive feedback appears to be mediated by a change in HC Ca2+, whereas negative feedback is mediated by a change in HC membrane potential. Local uncaging of AMPA receptor agonists suggests that positive feedback is spatially constrained to active HC-cone synapses, whereas the negative feedback signal spreads through HCs to affect release from surrounding cones. By locally offsetting the effects of negative feedback, positive feedback may amplify photoreceptor synaptic release without sacrificing HC-mediated contrast enhancement