The Interaction between Externalizing Proneness and Striatal Dopamine on Distinct Aspects of Reward Processing

Externalizing proneness, or impulse control and substance abuse problems, has been broadly associated with dysregulation in reward sensitivity. The goal of this investigation was to systematically determine the effects of distinct manifestations of externalizing proneness, namely disinhibition and substance abuse, on specific aspects of reward processing using a Research Domain Criteria approach. Additionally, this investigation examined whether striatal dopamine moderates the impact of externalizing proneness on reward processing. Striatal tonic dopamine levels were operationalized using spontaneous eyeblink rate. Participants completed disinhibition and substance abuse subscales of the brief form Externalizing Spectrum Inventory, and then performed assessments of reward wanting and learning, devaluation sensitivity, effort expenditure for rewards, and reward-incentivized cognitive control. Results revealed that disinhibition and substance abuse exerted unique effects on reward processing, which were moderated by variation in striatal dopamine levels. High-disinhibited individuals with low striatal dopamine showed greater reward wanting and preferred less physically effortful, smaller rewards. Individuals with substance abuse problems and high striatal dopamine showed enhanced long-term reward learning, while high substance users with low dopamine showed enhanced learning of immediately rewarding options, exerted greater cognitive effort to obtain rewards, and showed deficits in reward- incentivized cognitive control. Substance abuse, independent of striatal dopamine, was associated with reduced reward devaluation sensitivity. Collectively, these results suggest that in individuals with externalizing proneness, low striatal dopamine may represent a risk factor for addiction or elevated impulse control problems

Effects of emotion on prospection during decision-making

In two experiments we examined the role of emotion, specifically worry, anxiety, and mood, on prospection during decision-making. Worry is a particularly relevant emotion to study in the context of prospection because high levels of worry may make individuals more aversive toward the uncertainty associated with the prospect of obtaining future improvements in rewards or states. Thus, high levels of worry might lead to reduced prospection during decision-making and enhance preference for immediate over delayed rewards. In Experiment 1 participants performed a two-choice dynamic decision-making task where they were required to choose between one option (the decreasing option) which provided larger immediate rewards but declines in future states, and another option (the increasing option) which provided smaller immediate rewards but improvements in future states, making it the optimal choice. High levels of worry were associated with poorer performance in the task. Additionally, fits of a sophisticated reinforcement-learning model that incorporated both reward-based and state-based information suggested that individuals reporting high levels of worry gave greater weight to the immediate rewards they would receive on each trial than to the degree to which each action would lead to improvements in their future state. In Experiment 2 we found that high levels of worry were associated with greater delay discounting using a standard delay discounting task. Combined, the results suggest that high levels of worry are associated with reduced prospection during decision-making. We attribute these results to high worriers' aversion toward the greater uncertainty associated with attempting to improve future rewards than to maximize immediate reward. These results have implications for researchers interested in the effects of emotion on cognition, and suggest that emotion strongly affects the focus on temporal outcomes during decision-making.The open access fee for this work was funded through the Texas A&M University Open Access to Knowledge (OAK) Fund

Decomposing the roles of perseveration and expected value representation in models of the Iowa gambling task

Models of human behavior in the Iowa Gambling Task (IGT) have played a pivotal role in accounting for behavioral differences during decision-making. One critical difference between models that have been used to account for behavior in the IGT is the inclusion or exclusion of the assumption that participants tend to persevere, or stay with the same option over consecutive trials. Models that allow for this assumption include win-stay-lose-shift (WSLS) models and reinforcement learning (RL) models that include a decay learning rule where expected values for each option decay as they are chosen less often. One shortcoming of RL models that have included decay rules is that the tendency to persevere by sticking with the same option has been conflated with the tendency to select the option with the highest expected value because a single term is used to represent both of these tendencies. In the current work we isolate the tendencies to perseverate and to select the option with the highest expected value by including them as separate terms in a Value-Plus-Perseveration (VPP) RL model. Overall the VPP model provides a better fit to data from a large group of participants than models that include a single term to account for both perseveration and the representation of expected value. Simulations of each model show that the VPP model's simulated choices most closely resemble the decision-making behavior of human subjects. In addition, we also find that parameter estimates of loss aversion are more strongly correlated with performance when perseverative tendencies and expected value representations are decomposed as separate terms within the model. The results suggest that the tendency to persevere and the tendency to select the option that leads to the best net payoff are central components of decision-making behavior in the IGT. Future work should use this model to better examine decision-making behavior

Older and younger adults are influenced differently by dark pattern designs

Considering that prior research has found older users undergo a different privacy decision-making process compared to younger adults, more research is needed to inform the behavioral privacy disclosure effects of these strategies for different age groups. To address this gap, we used an existing dataset of an experiment with a photo-tagging Facebook application. This experiment had a 2x2x5 between-subjects design where the manipulations were common dark pattern design strategies: framing (positive vs. negative), privacy defaults (opt-in vs. opt-out), and justification messages (positive normative, negative normative, positive rationale, negative rationale, none). We compared older (above 65 years old, N=44) and young adults (18 to 25 years old, N=162) privacy concerns and disclosure behaviors (i.e., accepting or refusing automated photo tagging) in the scope of dark pattern design. Overall, we find support for the effectiveness of dark pattern designs in the sense that positive framing and opt-out privacy defaults significantly increased disclosure behavior, while negative justification messages significantly decreased privacy concerns. Regarding older adults, our results show that certain dark patterns do lead to more disclosure than for younger adults, but also to increased privacy concerns for older adults than for younger

Preliminary Evidence of the Association between Time on Buprenorphine and Cognitive Performance among Individuals with Opioid Use Disorder Maintained on Buprenorphine: A Pilot Study

People on buprenorphine maintenance treatment (BMT) commonly present cognitive deficits that have been associated with illicit drug use and dropout from buprenorphine treatment. This study has compared cognitive responses to the Stroop Task and the Continuous Performance Task (CPT) among individuals on BMT, with recent drug use, and healthy controls and explored the associations between cognitive responses and drug use, craving, and buprenorphine use among participants on BMT. The participants were 16 individuals on BMT and 23 healthy controls. All participants completed a 60 min laboratory session in which they completed the Stroop Task and the CPT, a saliva drug test, a brief clinical history that collected substance-use- and treatment-related information, and the Opioid Craving Scale. The results showed that the BMT participants presented more commission errors (MBMT participants = 2.49; Mhealthy controls = 1.38; p = 0.048) and longer reaction times (MBMT participants = 798.09; Mhealthy controls = 699.09; p = 0.047) in the Stroop Task than did the healthy controls. More days on buprenorphine were negatively associated with reaction time in the CPT (−0.52) and the number of commission errors (−0.53), simple reaction time (−0.54), and reaction time correct (−0.57) in the Stroop Task. Neither drug use nor craving was significantly associated with the results for the cognitive tasks. Relative to the control participants, the BMT individuals performed worse in terms of longer reaction times and more commission errors in the Stroop Task. Within the BMT participants, longer times on buprenorphine were associated with better cognitive results in terms of faster reaction times for both tasks and lower commission errors for the Stroop Task