Catecholamine stress alters neutrophil trafficking and impairs wound healing by β2-adrenergic receptor-mediated upregulation of IL-6.

Stress-induced hormones can alter the inflammatory response to tissue injury; however, the precise mechanism by which epinephrine influences inflammatory response and wound healing is not well defined. Here we demonstrate that epinephrine alters the neutrophil (polymorphonuclear leukocyte (PMN))-dependent inflammatory response to a cutaneous wound. Using noninvasive real-time imaging of genetically tagged PMNs in a murine skin wound, chronic, epinephrine-mediated stress was modeled by sustained delivery of epinephrine. Prolonged systemic exposure of epinephrine resulted in persistent PMN trafficking to the wound site via an IL-6-mediated mechanism, and this in turn impaired wound repair. Further, we demonstrate that β2-adrenergic receptor-dependent activation of proinflammatory macrophages is critical for epinephrine-mediated IL-6 production. This study expands our current understanding of stress hormone-mediated impairment of wound healing and provides an important mechanistic link to explain how epinephrine stress exacerbates inflammation via increased number and lifetime of PMNs

Ampliação do Estudo de Validação da Escala Estilos de Pensar e Criar: Desenvolvimento de uma Versão Reduzida

There are several measures of cognition and creative styles, however few of them are valid and short enough to be administered in different settings. Therefore, this study had two purposes: to reanalyze and obtain validity evidence of the Scale of Thinking and Creative Scale (STCS), developed by Wechsler, measuring fve styles, based on a progression of increasingly rigorous exploratory and confrmatory factor analytic procedures, and (b) to provide a viable psychometrically sound short version of this scale. Based on a sample of 1,752 Brazilians (55% women; ages 14 to 70) living in four states (93% from Sao Paulo), results strongly supported fve dimensions of thinking and creative style, thus indicating the validity and reliability of the abridged STCS version.Existem várias medidas de estilos de pensar e criar, porém poucas são validadas e suficientemente curtas para administração em diferentes ambientes. Portanto, este estudo teve dois objetivos: (a) reanalisar e validar a Escala de Estilos de Pensar e Criar, desenvolvida por Wechsler, que mede cinco estilos, baseando-se em uma progressão de procedimentos estatísticos rigorosos de análises fatorial exploratória e confirmatória; (b) propor uma versão reduzida dessa escala, atendendo aos parâmetros psicométricos. Baseando-se em amostra de 1.752 brasileiros (55% mulheres, idades 14-70 anos) vivendo em quatro estados (93% de SP), os resultados demonstraram que existem cinco dimensões dos estilos de pensar e criar, que podem ser medidos de forma válida e precisa por meio de uma versão reduzida desta escala

Large-Scale Release of Campylobacter Draft Genomes: Resources for Food Safety and Public Health from the 100K Pathogen Genome Project.

Campylobacter is a food-associated bacterium and a leading cause of foodborne illness worldwide, being associated with poultry in the food supply. This is the initial public release of 202 Campylobacter genome sequences as part of the 100K Pathogen Genome Project. These isolates represent global genomic diversity in the Campylobacter genus

Genomic Scans across Three Eucalypts Suggest that Adaptation to Aridity is a Genome-Wide Phenomenon

Widespread species spanning strong environmental (e.g., climatic) gradients frequently display morphological and physiological adaptations to local conditions. Some adaptations are common to different species that occupy similar environments. However, the genomic architecture underlying such convergent traits may not be the same between species. Using genomic data from previous studies of three widespread eucalypt species that grow along rainfall gradients in southern Australia, our probabilistic approach provides evidence that adaptation to aridity is a genome-wide phenomenon, likely to involve multiple and diverse genes, gene families and regulatory regions that affect a multitude of complex genetic and biochemical processes

Understanding the Relationships between Tourists’ Emotional Experiences, Perceived Overall Image, Satisfaction, and Intention to Recommend

The purpose of this study is to empirically test an integrative model linking tourists' emotional experiences, perceived overall image, satisfaction, and intention to recommend. The model was tested using data collected from domestic tourists visiting Sardinia, Italy. Results show that tourists' emotional experiences act as antecedents of perceived overall image and satisfaction evaluations. In addition, overall image has a positive influence on tourist satisfaction and intention to recommend. The study expands current theorizations by examining the merits of emotions in tourist behavior models. From a practical perspective, the study offers important implications for destination marketers