Susceptibility of Gardnerella vaginalis to thiamphenicol: clinical experience with nonspecific vaginitis

We compared the in-vitro activity of thiamphenicol against 100 strains of Gardnerella vaginalis with the activity of 11 other antimicrobial agents. The MICs for thiamphenicol ranged from 0.39 micrograms/ml to 6.25 micrograms/ml. The concentration at which 50% of strains were inhibited (MIC50) was 1.96 micrograms/ml, and the concentration at which 90% of strains were inhibited (MIC90) was 3.93 micrograms/ml. All strains were very susceptible to erythromycin, chloramphenicol, beta-lactam antibiotics, and clindamycin. Tetracycline and metronidazole were only moderately active. In an attempt to cure G. vaginalis-associated vaginitis with a single-dose treatment, we administered 2.25 g of thiamphenicol to 20 volunteers; 17 were clinically and bacteriologically cured. In two cases we observed that G. vaginalis was not eliminated immediately (i.e., at the first follow-up visit), but we saw a progressive disappearance of the strain without further treatment. In one case the treatment seemed to have failed but reinfection could not be ruled out. The results show that a single dose of thiamphenicol can cure G. vaginalis-associated vaginitis</p

Evaluation of the in vitro activity of nifuroxazide on enteropathogenic microorganisms: determination of bacteriostatic and bactericidal concentrations and disk susceptibility36602

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Amoxicillin entry into human cerebrospinal fluid: comparison with ampicillin36588

The entry of amoxicillin and ampicillin into cerebrospinal fluid (CSF) of humans was studied in the absence of meningeal inflammation. Twelve volunteers received 33 mg of amoxicillin per kg intravenously over 30 min and nine volunteers received 33 mg of ampicillin per kg. The CSF specimens were sampled at 1, 2, and 4 h after the beginning of the infusion. Blood samples were obtained at the end of the infusion and at 45, 60, 90, 120, 180, and 240 min after the beginning of the infusion. Amoxicillin and ampicillin were both detected in the CSF. Ampicillin tended to give higher CSF levels than amoxicillin, although the difference was small. Serum concentrations of ampicillin equaled those of amoxicillin</p

The in-vitro activity of ceftazidime: comparison with other beta-lactam antibiotics36601

We have compared the in-vitro bacteriostatic and bactericidal activity of ceftazidime against cephalothin-resistant Gram-negative bacteria, Haemophilus influenzae and Gram-positive bacteria. Comparison was made with cefaperazone, cefuroxime, moxalactam, cefotaxime, cefamandole, cefoxitin, cephalothin, cefazolin, azlocillin, carbenicillin, ticarcillin, ampicillin and oxacillin. In general ceftazidime was one of the most active compounds with low MIC and MBC values</p

Towards a True Author Entry System for CAI

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