An intelligent, multi-transducer signal conditioning design for manufacturing applications

This paper describes a flexible, intelligent, high bandwidth, signal conditioning reference design and implementation, which is suitable for a wide range of force and displacement transducers in manufacturing applications. The flexibility inherent in the design has allowed more than 10 specialised transducer conditioning boards to be replaced by this single design, in a range of bespoke mechanical test equipment manufactured by the authors. The board is able to automatically reconfigure itself for a wide range of transducers and calibrate and balance the transducer. The range of transducers includes LVDT, AC/DC strain gauge and inductive bridges, and a range of standard industrial voltage current interface transducers. Further, with a minor lowcost addition to the transducer connector, the board is able to recognise the type of transducer, reconfigure itself and store the calibration data within the transducer, thereafter allowing a plugand-play operation as transducers are changed. The paper provides an example of the operation in typical manufacturing test application and illustrates the stability and noise performance of the design

Infant Drowning Prevention: Insights from a New Ecological Psychology Approach

Drowning causes significant mortality and morbidity globally, and infants (0–4 years of age) are disproportionately impacted. In a groundbreaking approach to pediatric drowning prevention, ecological psychology has been used to investigate the relationship between infants’ perceptual–motor development and their behavior around bodies of water. In this review, we summarize recent research findings in the field of ecological psychology and apply these to the prevention of infant drowning. Studies have linked infants’ avoidance of falls into the water with locomotor experience and type of accessway into bodies of water. Through crawling experience, infants learn to perceive the risk of falling into water and start adapting their behavior to avoid drop-offs leading into water. Infants tend to enter deep water more when the access is via a slope than via a drop-off. We propose that ecological psychology can enhance infant drowning prevention interventions. The aim is to create an additional layer of protection, the perceptual information layer, in addition to existing strategies, such as supervision and barriers. This new protective layer can be a powerful tool to further highlight the risk of entering the water and reduce infant drowning-related mortality and morbidity

Examining weather-related factors on physical activity levels of children from rural communities

Objective: The objective was to examine the influence of weather on moderate-to-vigorous physical activity (MVPA) and light physical activity (LPA) levels of children aged 8–14 years from rural communities, an understudied Canadian population. Methods: Children (n = 90) from four communities in rural Northwestern Ontario participated in this study between September and December 2016. Children’s MVPA and LPA were measured using an Actical accelerometer and demographic data were gathered from surveys of children and their parents. Weather data were collected from the closest weather station. Cross-classified regression models were used to assess the relationship between weather and children’s MVPA and LPA. Results: Boys accumulated more MVPA than girls (b = 26.38, p \u3c 0.01), children were more active on weekdays as compared with weekends (b = − 16.23, p \u3c 0.01), children were less active on days with precipitation (b = − 22.88, p \u3c 0.01), and higher temperature led to a significant increase in MVPA (b = 1.33, p \u3c 0.01). As children aged, they accumulated less LPA (b = − 9.36, p \u3c 0.01) and children who perceived they had higher levels of physical functioning got more LPA (b = 25.18, p = 0.02). Similar to MVPA, children had higher levels of LPA on weekdays (b = − 37.24, p \u3c 0.01) as compared to weekend days and children accumulated less LPA (b = −50.01, p \u3c 0.01) on days with rain. Conclusion: The study findings indicate that weather influences rural children’s MVPA and LPA. Future research is necessary to incorporate these findings into interventions to increase rural children’s overall PA levels and improve their overall health

Possible Association of APOE Genotype with Working Memory in Young Adults

Possession of the ε4 allele of the Apolipoprotein E (APOE) gene is associated with an increased risk of Alzheimer's disease. Early adult life effects of ε4 are less well understood. Working memory has been relatively little studied (compared to episodic memory) in relation to APOE genotype despite its importance in cognitive functioning. Our hypothesis was that ε4 would lead to an impairment in working memory in young adults.We studied working memory using a computerised n-back task in the Avon Longitudinal Study of Parents and Children (ALSPAC) at age 18. Data was available for 1049-1927 participants and for the 2- and 3-back versions of the task. Using multiple and multi-level regression controlling for important confounders we examined the association between APOE genotype on accuracy and reaction times.There was no evidence of a genotype effect on accuracy when the two difficulty levels were examined separately. There was some evidence to support a deleterious effect of the ε4 allele on n-back accuracy in the multi-level regression. There was weak evidence that the ε22 group were less accurate but the numbers were very low in this group. The ε34 group had faster reaction times than the reference ε33 group in all adjusted analyses but the ε44 group were only faster in the 3-back condition in multi-level analyses.There was no evidence of benefit in ε4 carriers, but there was some evidence of a detrimental effect on working memory in this large study

Examining weather-related factors on physical activity levels of children from rural communities

Objective: The objective was to examine the influence of weather on moderate-to-vigorous physical activity (MVPA) and light physical activity (LPA) levels of children aged 8–14 years from rural communities, an understudied Canadian population. Methods: Children (n = 90) from four communities in rural Northwestern Ontario participated in this study between September and December 2016. Children’s MVPA and LPA were measured using an Actical accelerometer and demographic data were gathered from surveys of children and their parents. Weather data were collected from the closest weather station. Cross-classified regression models were used to assess the relationship between weather and children’s MVPA and LPA. Results: Boys accumulated more MVPA than girls (b = 26.38, p \u3c 0.01), children were more active on weekdays as compared with weekends (b = − 16.23, p \u3c 0.01), children were less active on days with precipitation (b = − 22.88, p \u3c 0.01), and higher temperature led to a significant increase in MVPA (b = 1.33, p \u3c 0.01). As children aged, they accumulated less LPA (b = − 9.36, p \u3c 0.01) and children who perceived they had higher levels of physical functioning got more LPA (b = 25.18, p = 0.02). Similar to MVPA, children had higher levels of LPA on weekdays (b = − 37.24, p \u3c 0.01) as compared to weekend days and children accumulated less LPA (b = −50.01, p \u3c 0.01) on days with rain. Conclusion: The study findings indicate that weather influences rural children’s MVPA and LPA. Future research is necessary to incorporate these findings into interventions to increase rural children’s overall PA levels and improve their overall health

The effect of specific locomotor experiences on infants’ avoidance behaviour on real and water cliffs

© 2020 John Wiley & Sons Ltd Infants’ avoidance of drop-offs has been described as an affordance learning that is not transferable between different locomotor postures. In addition, there is evidence that infants perceive and act similarly around real and water cliffs. This cross-sectional study investigated the effects of specific locomotor experiences on infants’ avoidance behaviour using the Real Cliff/Water Cliff paradigm. The experiments included 102 infants, 58 crawling, but pre-walking, infants (Mage = 11.57 months, SD = 1.65) with crawling experience ranging between 0.03 and 7.4 months (M = 2.16, SD = 1.71) and 44 walking infants (Mage = 14.82 months, SD = 1.99), with walking experience ranging between 0.13 and 5.2 months (M = 1.86, SD = 1.28). The association between crawling experience and crawlers’ avoidance of the real and water cliffs was confirmed. Importantly, crawling and total self-produced locomotor experience, and not walking experience, were associated with walkers’ avoidance behaviour on both cliffs. These results suggest that some degree of perceptual learning acquired through crawling experience was developmentally transferred to the walking posture. A longer duration of crawling experience facilitates a more rapid recalibration to the new walking capability. In addition, there was no difference in infants’ avoidance of falling on the real and the water cliff. However, infants explored the water cliff more than the real cliff, revealing more enticement to examine bodies of water than for drop-offs

Nanotechnology in multimodal theranostic capsule endoscopy

Video capsule endoscopy (VCE) has become a clinically accepted diagnostic modality in the last 20 years and has established a technological roadmap for other capsule endoscopy (CE) devices, incorporating microscale technology, a local power supply and wireless communication. However, VCE does not provide a therapeutic function and research in therapeutic capsule endoscopy (TCE) has been limited. This paper proposes a new route towards viable TCE based on multiple CE devices including essential nanoscale components. A first device is used for multimodal diagnosis, with quantitative microultrasound as a complement to video imaging. Ultrasound-enhanced fluorescent marking of sites of pathology allows follow-up with a second device for therapy. This is based on fluorescence imaging and ultrasound-mediated targeted drug delivery. Subsequent treatment verification and monitoring with a third device exploits the minimally invasive nature of CE. Clinical implementation of a complete patient pathway remains the subject of research but several key components have been prepared in early prototype form. These are described, along with gaps that remain to be filled