Probe-based visual analysis of geospatial simulations

This work documents the design, development, refinement, and evaluation of probes as an interaction technique for expanding both the usefulness and usability of geospatial visualizations, specifically those of simulations. Existing applications that allow the visualization of, and interaction with, geospatial simulations and their results generally present views of the data that restrict the user to a single perspective. When zoomed out, local trends and anomalies become suppressed and lost; when zoomed in, spatial awareness and comparison between regions become limited. The probe-based interaction model integrates coordinated visualizations within individual probe interfaces, which depict the local data in user-defined regions-of-interest. It is especially useful when dealing with complex simulations or analyses where behavior in various localities differs from other localities and from the system as a whole. The technique has been incorporated into a number of geospatial simulations and visualization tools. In each of these applications, and in general, probe-based interaction enhances spatial awareness, improves inspection and comparison capabilities, expands the range of scopes, and facilitates collaboration among multiple users. The great freedom afforded to users in defining regions-of-interest can cause modifiable areal unit problems to affect the reliability of analyses without the user’s knowledge, leading to misleading results. However, by automatically alerting the user to these potential issues, and providing them tools to help adjust their selections, these unforeseen problems can be revealed, and even corrected

Author Correction: Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.

An amendment to this paper has been published and can be accessed via a link at the top of the paper

Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.

Risk for late-onset Alzheimer's disease (LOAD), the most prevalent dementia, is partially driven by genetics. To identify LOAD risk loci, we performed a large genome-wide association meta-analysis of clinically diagnosed LOAD (94,437 individuals). We confirm 20 previous LOAD risk loci and identify five new genome-wide loci (IQCK, ACE, ADAM10, ADAMTS1, and WWOX), two of which (ADAM10, ACE) were identified in a recent genome-wide association (GWAS)-by-familial-proxy of Alzheimer's or dementia. Fine-mapping of the human leukocyte antigen (HLA) region confirms the neurological and immune-mediated disease haplotype HLA-DR15 as a risk factor for LOAD. Pathway analysis implicates immunity, lipid metabolism, tau binding proteins, and amyloid precursor protein (APP) metabolism, showing that genetic variants affecting APP and Aβ processing are associated not only with early-onset autosomal dominant Alzheimer's disease but also with LOAD. Analyses of risk genes and pathways show enrichment for rare variants (P = 1.32 × 10-7), indicating that additional rare variants remain to be identified. We also identify important genetic correlations between LOAD and traits such as family history of dementia and education