Mouse Performance on a Novel Touchscreen Continuous Performance Task is Dependent on Signaling in the Prelimbic Cortex

Attention is the cognitive processing that facilitates the ability to target and attend to relevant environmental stimuli, while filtering out irrelevant or distracting stimuli. Control over selective attention is theorized to be dependent on organized neural communication that stems from the medial prefrontal cortex (mPFC). To evaluate selective and sustained attention, mice were trained on the novel touchscreen rodent continuous performance task (rCPT), a task designed to emulate the human CPT. In the rodent version, images are continuously presented on a touchscreen, where mice have been trained to selectively respond to one image type while suppressing responses to all others. Following training on the rCPT, bilateral cannulas were implanted into the prelimbic region of the mPFC. Immediately prior to cognitive testing, a mixture of GABA A and B agonists were infused into the prelimbic to temporarily inactivate the structure. Inactivating the prelimbic cortex significantly impaired performance on this task, resulting in a reduced ability to discriminate the target from non-target images, as well as a reduction in speed and overall responding. Currently, mice expressing optogenetic receptors are being used to evaluate how parvalbumin interneuron activity within the prelimbic cortex influences attentional performance on the rCPT. As the parvalbumin interneuron population is heavily implicated in generating coordinated neuronal activity and supporting cognition, it is predicted that inhibiting these interneurons and altering synchronous prelimbic activity will impair rCPT performance

Rover Traverse Planning to Support a Lunar Polar Volatiles Mission

Studies of lunar polar volatile depositsare of interest for scientific purposes to understandthe nature and evolution of the volatiles, and alsofor exploration reasons as a possible in situ resource toenable long term exploration and settlement of theMoon. Both theoretical and observational studies havesuggested that significant quantities of volatiles exist inthe polar regions, although the lateral and horizontaldistribution remains unknown at the km scale and finerresolution. A lunar polar rover mission is required tofurther characterize the distribution, quantity, andcharacter of lunar polar volatile deposits at thesehigher spatial resolutions. Here we present two casestudies for NASAs Resource Prospector (RP) missionconcept for a lunar polar rover and utilize this missionarchitecture and associated constraints to evaluatewhether a suitable landing site exists to support an RPflight mission

HERA Physics Beyond the Standard Model

The prospects of physics beyond the standard model in deep inelastic scattering are reviewed, emphasizing some scenarios which attained attention after the observation of an excess of events with large momentum transfer at HERA.Comment: 8 pages, LaTeX, uses iop style files and axodraw.sty, Talk presented at the 3rd UK Phenomenology Workshop on HERA Physics, September 1998, Durha

Two-Dimensional Distribution of Volatiles in the Lunar Regolith from Space Weathering Simulations

We present simulations of space weathering effects on ice deposits in regions of permanent shadow on the Moon. These Monte Carlo simulations follow the effects of space weathering processes on the distribution of the volatiles over time. The model output constrains the coherence of volatile deposits with depth, lateral separation, and time. The results suggest that ice sheets become broken and buried with time. As impacts begin to puncture an initially coherent surficial ice sheet, small areas with a deficit of ice compared to surrounding areas are formed first. As time progresses, holes become prevalent and the anomalous regions are local enhancements of ice concentration in a volume. The 3-D distribution is also heterogeneous because the ice is buried to varying depths in different locations. Analysis of the coherence of ice on 10 cm scales predicts that putative ice sheets in anomalous radar craters are 1000 Myr old. For future in situ analysis of cold trap volatiles, a horizontal range of 10 m is sufficient to acquire surface-based measurements of heterogeneously distributed ice. These results also support previous analyses that Mercury's cold traps are young

Probing Colored Particles with Photons, Leptons, and Jets

If pairs of new colored particles are produced at the Large Hadron Collider, determining their quantum numbers, and even discovering them, can be non-trivial. We suggest that valuable information can be obtained by measuring the resonant signals of their near-threshold QCD bound states. If the particles are charged, the resulting signatures include photons and leptons and are sufficiently rich for unambiguously determining their various quantum numbers, including the charge, color representation and spin, and obtaining a precise mass measurement. These signals provide well-motivated benchmark models for resonance searches in the dijet, photon+jet, diphoton and dilepton channels. While these measurements require that the lifetime of the new particles be not too short, the resulting limits, unlike those from direct searches for pair production above threshold, do not depend on the particles' decay modes. These limits may be competitive with more direct searches if the particles decay in an obscure way.Comment: 39 pages, 9 figures; v2: more recent searches include

Baryon polarization in low-energy unpolarized meson-baryon scattering

We compute the polarization of the final-state baryon, in its rest frame, in low-energy meson--baryon scattering with unpolarized initial state, in Unitarized BChPT. Free parameters are determined by fitting total and differential cross-section data (and spin-asymmetry or polarization data if available) for $pK^-$, $pK^+$ and $p\pi^+$ scattering. We also compare our results with those of leading-order BChPT

Photoproduction of pions and properties of baryon resonances from a Bonn-Gatchina partial wave analysis

Masses, widths and photocouplings of baryon resonances are determined in a coupled-channel partial wave analysis of a large variety of data. The Bonn-Gatchina partial wave formalism is extended to include a decomposition of t- and u-exchange amplitudes into individual partial waves. The multipole transition amplitudes for $\gamma p\to p\pi^0$ and $\gamma p\to n\pi^+$ are given and compared to results from other analyses.Comment: 18 pages, 14 figure

Precise Measurement of Sigma Beam Asymmetry for Positive Pion Photoproduction on the Proton from 800 to 1500 Mev

The Sigma beam asymmetry for positive pion photoproduction on the proton has been measured over an angular range of 40-170 deg at photon energies from 0.8 to 1.5 GeV. The resulting data set includes 237 accurate points, 136 of these belonging to an almost unexplored domain above 1.05 GeV. Data of such high precision provide severe constraints for partial wave analyses. The influence of this experiment on the GW multipole analysis is demonstrated. Significant changes are found in multipoles connected to the S31(1620) and P13(1720) resonances. Comparisons using the MAID analysis are also presented.Comment: 11 pages, 4 eps figures. to be published in Physics Letters

Heavy Flavour Physics at HERA - a Survey

At the HERA collider at DESY, high energy electron and positron beams interact with proton beams. A review is presented of the variety of ways in which these collisions produce final states containing charm and beauty quarks.Comment: 45 pages including 30 figures. Submitted to International Journal of Modern Physics

GoMiner: a resource for biological interpretation of genomic and proteomic data

We have developed GoMiner, a program package that organizes lists of 'interesting' genes (for example, under- and overexpressed genes from a microarray experiment) for biological interpretation in the context of the Gene Ontology. GoMiner provides quantitative and statistical output files and two useful visualizations. The first is a tree-like structure analogous to that in the AmiGO browser and the second is a compact, dynamically interactive 'directed acyclic graph'. Genes displayed in GoMiner are linked to major public bioinformatics resources