RT-2 Detection of Quasi-Periodic Pulsations in the 2009 July 5 Solar Hard X-ray Flare

We present the results of an analysis of hard X-ray observations of the C2.7 solar flare detected by the RT-2 Experiment onboard the Coronas - Photon satellite. We detect hard X-ray pulsations at periods of ~12 s and ~15 s. We find a marginal evidence for a decrease in period with time. We have augmented these results using the publicly available data from the RHESSI satellite. We present a spectral analysis and measure the spectral parameters.Comment: 12 pages, 8 figures and 3 tables, accepted for publication in The Astrophysical Journa

Composite Films of Arabinoxylan and Fibrous Sepiolite: Morphological, Mechanical, and Barrier Properties

Hemicelluloses represent a largely unutilized resource for future bioderived films in packaging and other applications. However, improvement of film properties is needed in order to transfer this potential into reality. In this context, sepiolite, a fibrous clay, was investigated as an additive to enhance the properties of rye flour arabinoxylan. Composite films cast from arabinoxylan solutions and sepiolite suspensions in water were transparent or semitransparent at additive loadings in the 2.5-10 wt % range. Scanning electron microscopy showed that the sepiolite was well dispersed in the arabinoxylan films and sepiolite fiber aggregation was not found. FT-IR spectroscopy provided some evidence for hydrogen bonding between sepiolite and arabinoxylan. Consistent with these findings, mechanical testing showed increases in film stiffness and strength with sepiolite addition and the effect of poly(ethylene glycol) methyl ether (mPEG) plasticizer addition. Incorporation of sepiolite did not significantly influence the thermal degradation or the gas barrier properties of arabinoxylan films, which is likely a consequence of sepiolite fiber morphology. In summary, sepiolite was shown to have potential as an additive to obtain stronger hemicellulose films although other approaches, possibly in combination with the use of sepiolite, would be needed if enhanced film barrier properties are required for specific applications.</p

Preclinical Development of PQR514, a Highly Potent PI3K Inhibitor Bearing a Difluoromethyl-Pyrimidine Moiety

The phosphoinositide 3-kinase (PI3K)/mechanistic target of rapamycin (mTOR) pathway is a critical regulator of cell growth and is frequently hyperactivated in cancer. Therefore, PI3K inhibitors represent a valuable asset in cancer therapy. Herein we have developed a novel anticancer agent, the potent pan-PI3K inhibitor PQR514 (4), which is a follow-up compound for the phase-II clinical compound PQR309 (1). Compound 4 has an improved potency both in vitro and in cellular assays with respect to its predecessor compounds. It shows superiority in the suppression of cancer cell proliferation and demonstrates significant antitumor activity in an OVCAR-3 xenograft model at concentrations approximately eight times lower than PQR309 (1). The favorable pharmacokinetic profile and a minimal brain penetration promote PQR514 (4) as an optimized candidate for the treatment of systemic tumors

TRANSPORT AND ECONOMIC BALANCE AND ITS ROLE IN THE COORDINATION OF TRANSPORT PLANNING DURING THE DIGITALIZATION ERA

Econometrics tools in framework of Transport and Economic Balance (TEB) for transport planning and forecasting are aimed at improving transport links and transport connectivity via accounting the ratio between the volume of production and consumption of goods and the demand for transport services for their import and export. The TEB’s econometrics model includes the basic balance equations that define its structure and formation rules. The transport and economic balance of the Russian Federation aggregate the actual and forecast freight flows and their correspondence between the regions of the country (OD-matrix) by rail, road, inland water and maritime transport by type of commodities. The balance of actual freight traffic built for 2007-2016 based on statistics for industrial production, domestic and external trade, construction, agriculture and energy, as well as statistics for rail, maritime, inland water and road transport. The forecast of the cargo base and freight traffic is built for the period up to 2030 using the scenarios and forecast estimations by the Ministry of Economic Development of Russia, as well as the indices of regional economic development, considering the technological and transport connectivity of main cargo generating industries. The TEB will make it possible to calculate and substantiate the predicted impacts on the infrastructure considering various options for its reconstruction and development, changing routes, optimally distribute the forecasted flows over the network, considering the predicted characteristics of throughput, speeds and predictability of delivery time, workload of transport network and elimination of bottlenecks

Detection of GRB 090618 with RT-2 Experiment Onboard the Coronas-Photon Satellite

We present the results of an analysis of the prompt gamma-ray emission from GRB 090618 using the RT-2 Experiment onboard the Coronas-Photon satellite. GRB 090618 shows multiple peaks and a detailed study of the temporal structure as a function of energy is carried out. As the GRB was incident at an angle of 77 degree to the detector axis, we have generated appropriate response functions of the detectors to derive the spectrum of this GRB. We have augmented these results using the publicly available data from the Swift BAT detector and show that a combined spectral analysis can measure the spectral parameters quite accurately. We also attempt a spectral and timing analysis of individual peaks and find evidence for a systematic change in the pulse emission characteristics for the successive pulses. In particular, we find that the peak energy of the spectrum, E_p, is found to monotonically decrease with time, for the successive pulses of this GRB.Comment: 12 pages, 6 figures, 3 tables, Accepted for publication in The Astrophysical Journa

Association between the NBS1 E185Q polymorphism and cancer risk: a meta-analysis

<p>Abstract</p> <p>Background</p> <p>NBS1 is a key DNA repair protein in the homologous recombination repair pathway and a signal modifier in the intra-S phase checkpoint that plays important roles in maintaining genomic stability. The <it>NBS1 </it>8360G>C (<it>Glu185Gln</it>) is one of the most commonly studied polymorphisms of the gene for their association with risk of cancers, but the results are conflicting.</p> <p>Methods</p> <p>We performed a meta-analysis using 16 eligible case-control studies (including 17 data sets) with a total of 9,734 patients and 10,325 controls to summarize the data on the association between the <it>NBS1 </it>8360G>C (E185Q) polymorphism and cancer risk.</p> <p>Results</p> <p>Compared with the common 8360GG genotype, the carriers of variant genotypes (i.e., 8360 GC/CC) had a 1.06-fold elevated risk of cancer (95% CI = 1.00–1.12, <it>P </it>= 0.05) in a dominant genetic model as estimated in a fixed effect model. However, the association was not found in an additive genetic model (CC <it>vs </it>GG) (odds ratio, OR = 0.98, 95% CI = 0.85–1.13, <it>P </it>= 0.78) nor in a recessive genetic model (CC <it>vs </it>GC +GG) (OR = 0.94, 95% CI = 0.82–1.07, <it>P </it>= 0.36). The effect of the 8360G>C (E185Q) polymorphism was further evaluated in stratification analysis. It was demonstrated that the increased risk of cancer associated with 8360G>C variant genotypes was more pronounced in the Caucasians (OR = 1.07, 95% CI = 1.01–1.14, <it>P </it>= 0.03).</p> <p>Conclusion</p> <p>Our meta-analysis suggests that the <it>NBS1 </it>E185Q variant genotypes (8360 <it>GC/CC</it>) might be associated with an increased risk of cancer, especially in Caucasians.</p

High frequency of BRCA1, but not CHEK2 or NBS1 (NBN), founder mutations in Russian ovarian cancer patients

<p>Abstract</p> <p>Background</p> <p>A significant portion of ovarian cancer (OC) cases is caused by germ-line mutations in BRCA1 or BRCA2 genes. BRCA testing is cheap in populations with founder effect and therefore recommended for all patients with OC diagnosis. Recurrent mutations constitute the vast majority of BRCA defects in Russia, however their impact in OC morbidity has not been yet systematically studied. Furthermore, Russian population is characterized by a relatively high frequency of CHEK2 and NBS1 (NBN) heterozygotes, but it remains unclear whether these two genes contribute to the OC risk.</p> <p>Methods</p> <p>The study included 354 OC patients from 2 distinct, geographically remote regions (290 from North-Western Russia (St.-Petersburg) and 64 from the south of the country (Krasnodar)). DNA samples were tested by allele-specific PCR for the presence of 8 founder mutations (BRCA1 5382insC, BRCA1 4153delA, BRCA1 185delAG, BRCA1 300T>G, BRCA2 6174delT, CHEK2 1100delC, CHEK2 IVS2+1G>A, NBS1 657del5). In addition, literature data on the occurrence of BRCA1, BRCA2, CHEK2 and NBS1 mutations in non-selected ovarian cancer patients were reviewed.</p> <p>Results</p> <p>BRCA1 5382insC allele was detected in 28/290 (9.7%) OC cases from the North-West and 11/64 (17.2%) OC patients from the South of Russia. In addition, 4 BRCA1 185delAG, 2 BRCA1 4153delA, 1 BRCA2 6174delT, 2 CHEK2 1100delC and 1 NBS1 657del5 mutation were detected. 1 patient from Krasnodar was heterozygous for both BRCA1 5382insC and NBS1 657del5 variants.</p> <p>Conclusion</p> <p>Founder BRCA1 mutations, especially BRCA1 5382insC variant, are responsible for substantial share of OC morbidity in Russia, therefore DNA testing has to be considered for every OC patient of Russian origin. Taken together with literature data, this study does not support the contribution of CHEK2 in OC risk, while the role of NBS1 heterozygosity may require further clarification.</p