Providing Trauma Informed Care with an Emphasis on Sexual Trauma: A Pilot Education Program to Students Providing Care to Latinx Patients in a Free Primary Care Clinic

Providing Trauma Informed Care with an Emphasis on Sexual Trauma: A Pilot Education Program to Students Providing Care to Latinx Patients in a Free Primary Care Clinic

Revisión de los enigmáticos roedores Cephalomyidae de Patagonia y Bolivia (Hystricognathi, Caviomorpha): sistemática, filogenia e historia evolutiva

Los Cephalomyidae son una familia de roedores caviomorfos extintos, con registros para el Oligoceno tardío (Deseadense)-Mioceno temprano (Colhuehuapense) de Argentina y Bolivia. A la fecha, esta familia incluye los géneros Cephalomys (Deseadense de Patagonia y Bolivia); Litodontomys (Deseadense de Patagonia); Soriamys y Banderomys (Colhuehuapense de Patagonia) y Cephalomyopsis (Deseadense-Colhuehuapense de Argentina y Bolivia). Autores previos también incluyeron en esta familia a los géneros Perimys, Scotamys, Asteromys y Palmiramys. La validez, contenidos y relaciones de los Cephalomyidae fueron ampliamente discutidos en la literatura. Sin embargo, no existen análisis filogenéticos que incluyan a todos los géneros que forman parte de la familia o que alguna vez fueron vinculados a la misma. Además, las especies del género Cephalomys necesitan una revisión.Fil: Busker, Felipe. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Geología y Paleontología; ArgentinaXXXII Jornadas Argentinas de MastozoologíaPuerto MadrynArgentinaSociedad Argentina para el Estudio de los MamíferosCentro Nacional PatagónicoUniversidad Nacional de la Patagonia San Juan Bosc

Organic redox-flow batteries using compounds out of bark and peat as well as humic acids

Redox-Flow-Batteries are currently being studied for the storage of wind and solar energy, especially the use of organic compounds as redox systems. With this communication we demonstrate, that these systems can be successfully used at school and in higher education. The focus is put upon the use of compounds found in bark and peat as well as humic acids. (DIPF/Orig.)Derzeit werden Redox-Flow-Batterien zur Speicherung von Wind- und Sonnenenergie untersucht, insbesondere die Nutzung organischer Verbindungen als Redoxsysteme. In diesem Artikel wird gezeigt, dass diese Systeme erfolgreich in der Schule und im Hochschulbereich eingesetzt werden können. Der Fokus liegt auf der Nutzung von Rinden- und Torfverbindungen sowie Huminsäuren

Physical Therapy Management of Articular Cartilage Lesion: A Case Report

Background and Purpose: Articular cartilage covers bony surfaces of joints to decrease friction. Lesions can be of varying severity and be symptomatic or asymptomatic. Current research has focused on surgical interventions with limited research on conservative management of these lesions. The purpose of this case study is to present conservative treatment and the outcomes of a patient experiencing symptoms related to an articular cartilage lesion. Case Description: Patient is a 41-year-old female referred to Physical Therapy for pain in the right knee. Main complaint was pain during and after running that prevented self-selected running duration and frequency. Findings from evaluation were decreased hip musculature endurance on right compared to left, testing of right gluteus medius resulted in tensor fascia latae compensation, tenderness to palpation at distal medial patella, decreased patellar mobility in all directions and decreased functional dorsiflexion range of motion on the right compared to the left. Interventions included a running program, therapeutic exercise (TE) and correction of body mechanics with functional movement. Outcomes: Patient’s overall pain level and symptoms decreased in intensity and frequency. Patient’s mental health improved on the Short Form-12 Health Survey. The Lysholm Knee Scoring Scale and International Knee Documentation Committee Subjective Knee Form demonstrated improved scores. Discussion: Physical Therapy proved to be an effective strategy to decrease symptoms and improve this patient’s overall function. Primary goal of returning to self-selected running duration and frequency was achieved. Continued research is needed to demonstrate the effect on Physical Therapy on various grades of articular cartilage lesions

A critical appraisal of "Effect of exercising at minimum recommendations of the multiple sclerosis exercise guideline combined with structured education or attention control education - secondary results of the step it up randomized controlled trial"

The purpose of this paper is to perform a critical review of an article as it relates to the clinical question: Is fatigue management more important than physical activity level to manage exacerbation relapse period frequency in patients with Multiple Sclerosis (MS). The article was appraised for its strengths and weaknesses concerning the introduction, methods, results, and discussion sections. Overall the article is very well written and exhibits many strengths. However, the article demonstrates minimal clinical significance once outcomes were obtained. Despite the decreased clinical significance the appraisal will show that the research study performed was a necessary, valid, and provides a framework to continue to explore the relationship between fatigue and physical activity in individuals diagnosed with MS. The importance of this appraisal is to determine if there are option available to decrease exacerbation seen in MS that leads to disability. Also to determine if managing fatigue on a educational and physical activity level results in improved quality of life in those individuals living with MS

Investigation of the mechanism of activation of the NO-sensitive guanylate cyclase and its subcellular localization

Der NO / cGMP-Signalweg spielt eine zentrale Rolle bei der Regulation des Blutdrucks und der Relaxation der glatten Muskulatur und bei der Thrombozytenaggregation. Das zentrale Enzym dieses Signalwegs ist die Stickstoffmonoxid-sensitive Guanylat-Cyclase (NOsGC). Gegenstand der Arbeit war die Untersuchung der dynamischen Konformationsänderungen der NOsGC bei NO-Stimulation unter Verwendung der endogenen Tryptophane als FRET-Donatoren und dem Substratanalogon 2´-Mant-3´-dGTP als FRET-Akzeptor. Die Ergebnisse weisen darauf hin, dass das NO-Aktivierungssignal von der HNOX-Domäne über zwei unterschiedliche Domänen auf die katalytische Domäne übertragen wird. Die Bewegung von Helices aus diesen beiden Domänen in Richtung der katalytischen Domäne führen dazu, dass sich diese schließt und in ihre aktive Konformation übergeht. Das Polaritätsprotein Scribble wurde im Rahmen dieser Arbeit als möglicher Interaktionspartner der α2-Untereinheit identifiziert. Untersuchungen der Lokalisation der α2 / β1 Isoform an Zell-Zell-Kontakten ergaben, dass nur das Heterodimer aus α2- und β1-Untereinheit die besondere Lokalisation zeigt, während die einzelne α2 Untereinheit zytosolisch verteilt ist. Zur Untersuchung der intrazelluläre und lokalisationsbezogene Aktivität der NOsGC wurden auf Basis des cGMP-Fluoreszenzindikators FlincG und den beiden Isoformen der NOsGC zwei monomolekulare Fluoreszenzsensoren charakterisiert. Der Einsatz der Fluoreszenzsensoren ergab, dass die besondere Lokalisation der α2 / β1-Isoform an Zell-Zell-Kontakten dem Abfangen von NO an der Membran dienen könnte und dass der NOsGC-Aktivator Cinaciguat einen schnellen Anstieg der intrazellulären NOsGC-Aktivität verursacht. Zusammenfassend konnte in dieser Arbeit das Verständnis der Signaltransduktion der NO-Aktivierung innerhalb der NOsGC erweitert werden. Zusätzlich konnten Einblicke in den Wirkmechanismus neuer Arzneistoffgruppen gewonnen werden, deren Zielstruktur die NOsGC ist.The NO / cGMP pathway plays a crucial role in the regulation of blood pressure and smooth muscle relaxation, platelet aggregation and in the central and peripheral neurotransmission. The key enzyme of this pathway is the nitric oxide-sensitive guanylate cyclase (NOsGC). In this study the dynamic conformational changes to NOsGC upon NO stimulation were examined through the use of the endogenous tryptophan residues of NOsGC as FRET donors and the substrate analogue 2'-Mant-3'- dGTP as a FRET acceptor. The results indicate that the activation signal from the amino terminal heme and NO binding domain (HNOX) is transmitted via two different domains to the carboxy terminal catalytic domain. After NO stimulation the movement of two helices from this domains leads to a closure of the catalytic domain and induces its active conformation. The regulator of cell polarity, scribble, was identified as an interaction partner of α2 / β1 isoform. Investigation of the localization of this isoform at cell-cell contacts revealed that only the heterodimer of α2 and β1 subunit is located at cell-cell contacts. To investigate the intracellular localization and activity of NOsGC two monomolecular fluorescent sensors based on the cGMP fluorescence indicator FlincG and the two NOsGC isoforms (α1 / β1 and α2 / β1) were developed and established. The use of the fluorescence sensors led to the observation that the special localization of the α2 / β1 isoform at cell-cell contacts serves to intercept NO on the membrane and reveal that the NOsGC activator cinaciguat causes a rapid increase in intracellular NOsGC activity. In summary, this study furthers the understanding of NO-signal transduction within the intact full-length NOsGC. In addition, experiments give insight into the activation mechanism of new NOsGC activator and stimulator drugs

First record of <i>Banderomys leanzai Kramarz</i>, 2005 (Rodentia, Caviomorpha) in Chubut Province, Patagonia (Argentina)

Cephalomyidae was established in the XIX century, and was considered by different authors as a heterogeneous group of hypsodont South American hystricognath rodents. Other authors corroborated this family as a natural group among caviomorphs and recognized some taxa recorded from the Deseadan-Colhuehuapian South American Land Mammals Ages (SALMAs). Among them, Banderomys leanzai (the only species of this genus) was, until now, characteristic and exclusive of the locality of Cerro Bandera (early Miocene, Colhuehuapian?, Neuquén Province, Argentina). The aim of this work is to report the first record of B. leanzai outside the type locality; the new specimens come from the early Miocene of central Chubut Province (Patagonia, Argentina). This new finding extends the geographical distribution of the species and increases the dental morphology knowledge of B. leanzai.Facultad de Ciencias Naturales y Muse

Model experiments on redox flow batteries

Redox-Flow-Batteries werden derzeit als eine mögliche Technologie zur Energiespeicherung im Rahmen der Energiewende diskutiert. Das Prinzip kann mit einfachen Modellversuchen demonstriert werden. (DIPF/Orig.)Redox flow batteries are currently being discussed as a possible energy storage technology as part of the energy transition. The principle can be demonstrated with simple model tests. (DIPF/Orig.