A comprehensive contribution of genes for aryl hydrocarbon receptor signaling pathway to hypertension susceptibility

The present study was designed to investigate whether genetic polymorphisms of the aryl hydrocarbon receptor (AHR) signaling pathway are involved in the molecular basis of essential hypertension (EH

Review of the research on the influence of different functional substituents of new 1,2,4-triazole derivatives on the compounds biological properties

Today, 1,2,4-triazole derivatives are a promising class of organic compounds. This is caused, first of all, by the possibility of various chemical modifications of the 1,2,4-triazole fragment due to the addition of typical pharmacophores, which contributes to the expansion of the new molecules’ arsenal. A significant number of the 1,2,4-triazole derivatives show biological properties, that postively affects the further process of the most promising substances’ introduction. The aim of the work was to analyze the influence of various functional substituents of the new 1,2,4-triazole derivatives on the indicators of the mentioned compounds’ biological activity. Literature sources containing information on the influence of various functional substituents of the new 1,2,4-triazole derivatives on the indicators of these compounds’ biological activity became the research materials. Methods were used in the work: analytical, bibliosemantic information search, generalization. Triazoles and their heterocyclic analogues are compounds that contain a certain amount of Nitrogen atoms in their composition, showing the properties of typical pharmacophores. Their derivatives are easily synthesized and can be transformed into various biologically active molecules. Information on the 1,2,4-triazole derivatives’ chemical modeling, which allows for purposefully obtaining compounds with the necessary biological properties, taking into account the toxicity indicators of new molecules, has been analyzed and summarized. The authors have proved, that the gradual and predicted introduction of various substituents into the molecule of 1,2,4-triazole derivatives leads to the appearance of new types of biological activity, in some cases it gives an increase in already existing activity indicators. Chemical compounds’ modification due to the substituents’ changing around the 1,2,4-triazole fragment fundamentally changes the type of biological activity of new molecules. This approach was chosen by the majority of scientists as promising one for the new biologically active substances’ search among the 1,2,4-triazole derivatives. The priority, relevance and perspective of such researches have been proved by not only domestic scientists’ teams. Recently, foreign investigators from Turkey, India, Korea, China, Egypt, etc. have been actively searching for new biologically active substances among the 1,2,4-triazole derivatives. The analysis of modern literary sources on the study of the new 1,2,4-triazole derivatives’ biological activity allows us to establish certain features of the various functional substituents’ influence on the types of biological activity and convincingly proves the outlook of further synthetic tests in the compounds’ specified series

Study of the Manufacturing Options for an Asymmetric Plate Made of 12X18N10T Steel

The analysis of possible options for manufacturing an asymmetric plate of 12X18N10T steel is presented. A phenomenological model of damage accumulation was used to analyse the probability of metal micro - and macro - destruction. The results of FEM modelling of technological processes of plate manufacturing are presented. Due to these results were made the conclusions about feasibility of their application based on the metal damage calculation. The choice of a rational technology to produce a plate is justified, in which the greatest metal ductility reserve takes place at a dangerous point. According to the proposed scheme, an experimental batch of plates have been made. © Published under licence by IOP Publishing Ltd

Modern approaches to studying the antimicrobial and antifungal activities of new 1,2,4-triazole derivatives

1,2,4-Triazole and its derivatives are a promising class of organic compounds. For a long time, they remain in the spotlight due to a number of unique properties: high ability to chemical transformations, the presence of various types of biological activity and, of course, low toxicity. Also, a number of 1,2,4-triazole derivatives are currently well studied and implemented in various spheres of human life as effective drugs, various plant protection products (growth stimulants, fungicides, herbicides), anti-corrosion materials, plasticizers, etc. The aim of the work was to analyze and systematize new data on antimicrobial and antifungal activity of 1,2,4-triazole derivatives and to select a promising area of ​​research based on the accumulation of a large amount of information on the properties of new 1,2,4-triazole derivatives. The analysis of modern sources of information in recent years argues and proves the prospects for finding new biologically active compounds in a number of 1,2,4-triazole derivatives. The information obtained clearly indicates the possibility of using 1,2,4-triazoles, which contain a Sulfur atom, as objects of study. 1,2,4-Triazole is one of the most well-known classes of biologically active compounds, which has a wide range of biological action. Derivatives of 1,2,4-triazole are characterized by the presence of antibacterial, antifungal, hypoglycemic, antihypertensive, analgesic, anti-inflammatory, antitumor, antiviral activities. The trend of creating new effective drugs based on 1,2,4-triazole derivatives is growing. Some of the drugs are 1,2,4-triazole derivatives: ribavirin (an antiviral agent), risatriptan (a selective 5HT1 serotonin receptor agonist), alprazolam (an anxiolytic agent), fluconazole, and itraconazole (antifungal drugs). Derivatives of this compound have proven themselves well in veterinary medicine. Drugs such as Avesstim, Trifuzol, Trifuzol-neo are immunostimulants and in various dosage forms (1%, 2% solutions, suppositories) are used in veterinary farms, in the private livestock sector and for pets. These facts are the best example for understanding the prospects of finding new molecules among 1,2,4-triazole derivatives

Molecular-genetic factors of genital endometriosis

Article concerns data of the comparative analysis of polymorphic options of genes at patients with genital endometriosis and women in control grou

Conditions of teaching foreign language discourse to students of natural specialties on the basis of professionally oriented project active

In this paper, we develop an algorithm for teaching foreign language professional discourse to students of natural specialties. To achieve this goal, the authors prefer the method of professionally-oriented projectsВ данной работе разрабатывается алгоритм обучения иноязычному профессиональному дискурсу студентов естественных специальностей. Для достижения поставленной цели авторы отдают предпочтение методу профессионально-ориентированных проекто

THE MODEL OF TEACHING WRITING AND WRITING OF ARGUMENTATIVE SPEECH IN ENGLISH OF STUDENTS OF A NON-LINGUISTIC UNIVERSITY

Данное исследование посвящено разработке авторской модели процесса обучения письменной аргументативной речи. Аргументация, как сложный речевой акт, не имеет коммуникативной функции на уровне предложения, но имеет ее на некотором более высоком текстовом уровне. Авторы предлагают осуществлять процесс формирования ПРАР через модульное обучение. Мобильность модулей делает процесс обучения гибким и позволяет планировать обучение исходя из потребностей и уровня студентовThis research is devoted to the development of author's model of training process of a written argumentative speech. The argument as the difficult speech act has no communicative function at the level of the offer, but it has it at some higher text level. The authors suggest to carry out the process of formation of WVAS through modular training. The mobility of modules does process of training flexible and allows to plan training proceeding from requirements and the level of students. This process is based on the didactic and methodical principles of training. The importance of the research seems that in modern conditions the ability logically and with deep arguments to make out the thoughts in oral and written language is necessar

Peculiarities of Differentiated Formation of Foreign Language Educational and Research Competence of Masters in Non-Linguistic Higher School

Рассмотрен вопрос дифференцированного формирования иноязычной учебно-исследовательской компетенции магистрантов технических вузов. Обоснована необходимость дифференцированного обучения: оно считается одним из действенных типов обучения в иноязычном образовании магистрантов технических институтов и позволяет адаптировать образовательную систему к уровням подготовки, интересам и личным особенностям обучающихся, а также способствует формированию у них стремления к развитию профессиональной компетентности.The issue of differentiated formation of foreign language education and research competence of masters of technical universities is considered. The necessity of differentiated education is substantiated, as it considered to be one of the effective types of training in foreign language education for masters of technical institutes and allows adapting the educational system to the levels of training, interests and personal characteristics of students, and also contributes to formation of the desire to develop their future professional competence. Special attention is paid to the stages of training

Quantitative determination of 4-((5-(decylthio)-4-methyl-4-h-1,2,4-triazol-3-yl)methyl)morpholine in the soft medicinal form by spectrophotometric method

Synthetic biologically active compounds are the active pharmaceutical ingredients of various dosage forms that are widely used in both human and veterinary medicine. Nowadays the development of new effective antimicrobial and antifungal drugs remains a actual problem. This fact has a reasoned explanation in connection with the increase in infectious diseases of microbial and fungal etiology and the ever-growing resistance of microorganisms and fungi to various drugs. The aim of this research was to develop and validate a new spectrophotometric method for the quantitative determination of 4-((5-(decylthio)-4-methyl-4-H-1,2,4-triazol-3-yl)methyl)morpholine in 7% ointment by intrinsic absorption. At the stage of development of the quantitative determination method, the solvent was selected based on the solubility of the active substance. According to the data provided, 4-((5-(decylthio)-4-methyl-4-H-1,2,4-triazol-3-yl)methyl)morpholine is insoluble in water, but soluble in ethanol, methanol, isopropanol, dioxane, and dimethyl sulfoxide. Ethanol was chosen as the most accessible and less toxic solvent for the development of this method. Studied 4-((5-(decylthio)-4-methyl-4-H-1,2,4-triazol-3-yl)methyl)morpholine dissolved in ethanol is introduced into the ointment base as a solution. The quantitative content of substances subject to chemical control in soft dosage forms should be between 90% and 110% of the nominal content. On this basis, the maximum permitted analytical uncertainty can be determined, which is 3.20. During the procedure the main validation characteristics were determined, such as: linearity, precision, accuracy and robustness. Thus, a new sensitive, economical and easy-to-use spectrophotometric method for the quantitative determination of 4-((5-(decylthio)-4-methyl-4-H-1,2,4-triazol-3-yl)methyl)morpholine in a soft dosage form for external use (7% ointment) by the intrinsic absorption method was developed. According to the main validation characteristics (linearity, precision, accuracy and robustness), the proposed method is valid and meets the requirements of the State Pharmacopoeia of Ukraine