Immune responses and HIV: a little order from the chaos

HIV is evolution gone mad and bad. The virus infects a person and rapidly diversifies to become a huge swarm of viruses, each equipped differently to resist the onslaught of diverse T cells and antibodies. We can't expect to predict details of the struggle between virus and immunity, right? Wrong—maybe we can make some predictions, say two new landmark studies with potentially huge consequences for AIDS vaccine design

Panel 7 Target Journals for Information Systems Research: Current Practices and Controversies

This panel examines the practice of identifying target journals for IS research. As participants in a scholarly community, individual researchers and their institutions may benefit from guidance on the choice of journals for submission of scholarly work. Official “target journal” lists have begun to appear within departments, where they play a role in evaluating the contributions of individual faculty. The panel examines this practice from three distinct angles. First, research that evaluates the relative standing of scholarly journals in the IS field will be described. The results of a 1998 survey and two earlier surveys (Hardgrave and Walstrom 1997; Walstrom Hardgrave, and Wilson 1995) will be presented. Second, the current practices of two leading IS departments in North American business schools will be described. The actual lists, the controversies surrounding their development and maintenance, and their use and consequences will be described. Third, the practice of identifying target journals will be challenged, and the controversies surrounding the use of such lists will be examined

bNAber: database of broadly neutralizing HIV antibodies.

The discovery of broadly neutralizing antibodies (bNAbs) has provided an enormous impetus to the HIV vaccine research and to entire immunology. The bNAber database at http://bNAber.org provides open, user-friendly access to detailed data on the rapidly growing list of HIV bNAbs, including neutralization profiles, sequences and three-dimensional structures (when available). It also provides an extensive list of visualization and analysis tools, such as heatmaps to analyse neutralization data as well as structure and sequence viewers to correlate bNAbs properties with structural and sequence features of individual antibodies. The goal of the bNAber database is to enable researchers in this field to easily compare and analyse available information on bNAbs thereby supporting efforts to design an effective vaccine for HIV/AIDS. The bNAber database not only provides easy access to data that currently is scattered in the Supplementary Materials sections of individual papers, but also contributes to the development of general standards of data that have to be presented with the discovery of new bNAbs and a universal mechanism of how such data can be shared

The concentration and metabolism of sugar in ram semen

Publication authorized December 16, 1941.Digitized 2007 AES.Includes bibliographical references (pages 33-35)

Effects of clearcutting on the vegetation and soil of a sugar maple-dominated ecosystem, western upper Michigan

The effects 50 years after clearcutting on the vegetation and soil of an ecosystem type dominated by sugar maple (Acer saccharum) were studied at four locations along the boundaries of the Sylvania Recreation Area (Ottawa National Forest) in western Upper Michigan, U.S.A. Commercially clearcut areas along the boundaries of the undisturbed 8500-ha tract enabled study of vegetation and soil in paired cut and uncut plots. Overstories of the clearcut plots exhibit increased stem densities and decreased basal area and stem diameters compared to those of uncut plots. Both the relative density of understory sugar maple and the total density of all understory trees decreased significantly on the clearcut plots. Groups of herbaceous species characteristic of the ground cover of the clearcut plots were identical to those found on the uncut plots.There was no change in (1) thickness, mass, or total nutrient (K+, Mg2+, Ca2+) contents of the forest floor, or (2) acidity of the upper horizons of the mineral soil. The exchangeable potassium levels in the upper horizons of the mineral soil decreased significantly, and also there was a decreasing trend in the levels of exchangeable calcium and magnesium.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/26715/1/0000265.pd

Identification and specificity of broadly neutralizing antibodies against HIV

Summary Beginning in 2009, studies of the humoral responses of HIV‐positive individuals have led to the identification of scores, if not hundreds, of antibodies that are both broadly reactive and potently neutralizing. This development has provided renewed impetus toward an HIV vaccine and led directly to the development of novel immunogens. Advances in identification of donors with the most potent and broad anti‐HIV serum neutralizing responses were crucial in this effort. Equally, development of methods for the rapid generation of human antibodies from these donors was pivotal. Primarily these methods comprise single B‐cell culture coupled to high‐throughput neutralization screening and flow cytometry‐based sorting of single B cells using HIV envelope protein baits. In this review, the advantages and disadvantages of these methodologies are discussed in the context of the specificities targeted by individual antibodies and the need for further improvements to evaluate HIV vaccine candidates

Resonant electron transmission through a finite quantum spin chain

Electron transport in a finite one dimensional quantum spin chain (with ferromagnetic exchange) is studied within an $s-d$ exchange Hamiltonian. Spin transfer coefficients strongly depend on the sign of the $s-d$ exchange constant. For a ferromagnetic coupling, they exhibit a novel resonant pattern, reflecting the salient features of the combined electron-spin system. Spin-flip processes are inelastic and feasible at finite voltage or at finite temperature.Comment: 4 pages including 4 .eps figure

Complete replication of hepatitis C virus in cell culture.

Many aspects of the hepatitis C virus (HCV) life cycle have not been reproduced in cell culture, which has slowed research progress on this important human pathogen. Here, we describe a full-length HCV genome that replicates and produces virus particles that are infectious in cell culture (HCVcc). Replication of HCVcc was robust, producing nearly 10(5) infectious units per milliliter within 48 hours. Virus particles were filterable and neutralized with a monoclonal antibody against the viral glycoprotein E2. Viral entry was dependent on cellular expression of a putative HCV receptor, CD81. HCVcc replication was inhibited by interferon-alpha and by several HCV-specific antiviral compounds, suggesting that this in vitro system will aid in the search for improved antivirals