Slip avalanches in a fiber bundle model

We study slip avalanches in disordered materials under an increasing external load in the framework of a fiber bundle model. Over-stressed fibers of the model do not break, instead they relax in a stick-slip event which may trigger an entire slip avalanche. Slip avalanches are characterized by the number slipping fibers, by the slip length, and by the load increment, which triggers the avalanche. Our calculations revealed that all three quantities are characterized by power law distributions with universal exponents. We show by analytical calculations and computer simulations that varying the amount of disorder of slip thresholds and the number of allowed slips of fibers, the system exhibits a disorder induced phase transition from a phase where only small avalanches are formed to another one where a macroscopic slip appears.Comment: 6 pages, 6 figure

Periodicity and criticality in the Olami-Feder-Christensen model of earthquakes

Characteristic versus critical features of earthquakes are studied on the basis of the Olami-Feder-Christensen model. It is found that the local recurrence-time distribution exhibits a sharp $\delta$-function-like peak corresponding to rhythmic recurrence of events with a fixed ``period'' uniquely determined by the transmission parameter of the model, together with a power-law-like tail corresponding to scale-free recurrence of events. The model exhibits phenomena closely resembling the asperity known in seismology

The complex scaling behavior of non--conserved self--organized critical systems

The Olami--Feder--Christensen earthquake model is often considered the prototype dissipative self--organized critical model. It is shown that the size distribution of events in this model results from a complex interplay of several different phenomena, including limited floating--point precision. Parallels between the dynamics of synchronized regions and those of a system with periodic boundary conditions are pointed out, and the asymptotic avalanche size distribution is conjectured to be dominated by avalanches of size one, with the weight of larger avalanches converging towards zero as the system size increases.Comment: 4 pages revtex4, 5 figure

Simulation of the Burridge-Knopoff Model of Earthquakes with Variable Range Stress Transfer

Simple models of earthquake faults are important for understanding the mechanisms for their observed behavior, such as Gutenberg-Richter scaling and the relation between large and small events, which is the basis for various forecasting methods. Although cellular automaton models have been studied extensively in the long-range stress transfer limit, this limit has not been studied for the Burridge-Knopoff model, which includes more realistic friction forces and inertia. We find that the latter model with long-range stress transfer exhibits qualitatively different behavior than both the long-range cellular automaton models and the usual Burridge-Knopoff model with nearest neighbor springs, depending on the nature of the velocity-weakening friction force. This result has important implications for our understanding of earthquakes and other driven dissipative systems.Comment: 4 pages, 5 figures, published on Phys. Rev. Let

The Nuclear Guanine Nucleotide Exchange Factors Ect2 and Net1 Regulate RhoB-Mediated Cell Death after DNA Damage

Commonly used antitumor treatments, including radiation and chemotherapy, function by damaging the DNA of rapidly proliferating cells. However, resistance to these agents is a predominant clinical problem. A member of the Rho family of small GTPases, RhoB has been shown to be integral in mediating cell death after ionizing radiation (IR) or other DNA damaging agents in Ras-transformed cell lines. In addition, RhoB protein expression increases after genotoxic stress, and loss of RhoB expression causes radio- and chemotherapeutic resistance. However, the signaling pathways that govern RhoB-induced cell death after DNA damage remain enigmatic. Here, we show that RhoB activity increases in human breast and cervical cancer cell lines after treatment with DNA damaging agents. Furthermore, RhoB activity is necessary for DNA damage-induced cell death, as the stable loss of RhoB protein expression using shRNA partially protects cells and prevents the phosphorylation of c-Jun N-terminal kinases (JNKs) and the induction of the pro-apoptotic protein Bim after IR. The increase in RhoB activity after genotoxic stress is associated with increased activity of the nuclear guanine nucleotide exchange factors (GEFs), Ect2 and Net1, but not the cytoplasmic GEFs p115 RhoGEF or Vav2. Importantly, loss of Ect2 and Net1 via siRNA-mediated protein knock-down inhibited IR-induced increases in RhoB activity, reduced apoptotic signaling events, and protected cells from IR-induced cell death. Collectively, these data suggest a mechanism involving the nuclear GEFs Ect2 and Net1 for activating RhoB after genotoxic stress, thereby facilitating cell death after treatment with DNA damaging agents

Entrainment by turbulent fountains

This is the author accepted manuscript. The final version is available from Cambridge University Press via https://doi.org/10.1017/jfm.2016.16Experimental measurements of entrainment by turbulent fountains from circular sources in quiescent uniform environments are presented. Our results span almost four orders of magnitude in the source Froude number (0.004 ≤ Fr₀ ≤ 25) and thereby encompass the entrainment across all classes of fountain behaviour identified to date. We identify scalings for the entrained volume flux Qᴇ, in terms of Fr₀ and the source volume flux Q₀, within a number of distinct Froude-number bands corresponding to each class of fountain. Additionally we identify a distinct class of new behaviour, as yet unreported, for Fr₀ ≲ 0.1

Optimal design of adaptively sampled NMR experiments for measurement of methyl group dynamics with application to a ribosome-nascent chain complex

NMR measurements of cross-correlated nuclear spin relaxation provide powerful probes of polypeptide dynamics and rotational diffusion, free from contributions due to chemical exchange or interactions with external spins. Here, we report on the development of a sensitivity-optimized pulse sequence for the analysis of the differential relaxation of transitions within isolated 13CH3 spin systems, in order to characterise rotational diffusion and side chain order through the product S2τc. We describe the application of optimal design theory to implement a real-time ‘on-the-fly’ adaptive sampling scheme that maximizes the accuracy of the measured parameters. The increase in sensitivity obtained using this approach enables quantitative measurements of rotational diffusion within folded states of translationally-arrested ribosome–nascent chain complexes of the FLN5 filamin domain, and can be used to place strong limits on interactions between the domain and the ribosome surface

Asperity characteristics of the Olami-Feder-Christensen model of earthquakes

Properties of the Olami-Feder-Christensen (OFC) model of earthquakes are studied by numerical simulations. The previous study indicated that the model exhibits ``asperity''-like phenomena, {\it i.e.}, the same region ruptures many times near periodically [T.Kotani {\it et al}, Phys. Rev. E {\bf 77}, 010102 (2008)]. Such periodic or characteristic features apparently coexist with power-law-like critical features, {\it e.g.}, the Gutenberg-Richter law observed in the size distribution. In order to clarify the origin and the nature of the asperity-like phenomena, we investigate here the properties of the OFC model with emphasis on its stress distribution. It is found that the asperity formation is accompanied by self-organization of the highly concentrated stress state. Such stress organization naturally provides the mechanism underlying our observation that a series of asperity events repeat with a common epicenter site and with a common period solely determined by the transmission parameter of the model. Asperity events tend to cluster both in time and in space

Colocalization of F-actin and talin during Fc receptor-mediated phagocytosis in mouse macrophages

We have studied the distribution of talin in J774 cells and mouse peritoneal macrophages undergoing Fc receptor-mediated phagocytosis. At early stages of phagocytosis, talin accumulates in the cells' cortical cytoplasm adjacent to the forming phagosome and extends into pseudopods that are encircling the particle. Talin colocalizes with F-actin at these sites. After particle ingestion is completed, F-actin and talin are no longer concentrated adjacent to phagosomes. Thus, talin and F-actin undergo dynamic and coordinate changes in their cytoplasmic location during Fc receptor-mediated phagocytosis

Functional Electrical Stimulation mediated by Iterative Learning Control and 3D robotics reduces motor impairment in chronic stroke

Background: Novel stroke rehabilitation techniques that employ electrical stimulation (ES) and robotic technologies are effective in reducing upper limb impairments. ES is most effective when it is applied to support the patients’ voluntary effort; however, current systems fail to fully exploit this connection. This study builds on previous work using advanced ES controllers, and aims to investigate the feasibility of Stimulation Assistance through Iterative Learning (SAIL), a novel upper limb stroke rehabilitation system which utilises robotic support, ES, and voluntary effort. Methods: Five hemiparetic, chronic stroke participants with impaired upper limb function attended 18, 1 hour intervention sessions. Participants completed virtual reality tracking tasks whereby they moved their impaired arm to follow a slowly moving sphere along a specified trajectory. To do this, the participants’ arm was supported by a robot. ES, mediated by advanced iterative learning control (ILC) algorithms, was applied to the triceps and anterior deltoid muscles. Each movement was repeated 6 times and ILC adjusted the amount of stimulation applied on each trial to improve accuracy and maximise voluntary effort. Participants completed clinical assessments (Fugl-Meyer, Action Research Arm Test) at baseline and post-intervention, as well as unassisted tracking tasks at the beginning and end of each intervention session. Data were analysed using t-tests and linear regression. Results: From baseline to post-intervention, Fugl-Meyer scores improved, assisted and unassisted tracking performance improved, and the amount of ES required to assist tracking reduced. Conclusions: The concept of minimising support from ES using ILC algorithms was demonstrated. The positive results are promising with respect to reducing upper limb impairments following stroke, however, a larger study is required to confirm this