Replication of Molluscum Contagiosum Virus

AbstractMolluscum contagiosum virus (MCV) infects preadolescent children and sexually active adults, frequently causing a disfiguring cutaneous disease in immunosuppressed HIV-infected individuals. The development of an efficacious treatment regime has been hampered by the failure to replicate the virus in the laboratory. Here we report the first demonstration of MCV replication in an experimental system. In human foreskin grafts to athymic mice, MCV induced morphological changes which were indistinguishable from patient biopsies and included the development and migration of molluscum bodies containing mature virions to the epidermal surface

Greenhouse gas balance over thaw-freeze cycles in discontinuous zone permafrost

Peat in the discontinuous permafrost zone contains a globally significant reservoir of carbon that has undergone multiple permafrost-thaw cycles since the end of the mid-Holocene (~3700 years before present). Periods of thaw increase C decomposition rates which leads to the release of CO2 and CH4 to the atmosphere creating potential climate feedback. To determine the magnitude and direction of such feedback, we measured CO2 and CH4 emissions and modeled C accumulation rates and radiative fluxes from measurements of two radioactive tracers with differing lifetimes to describe the C balance of the peatland over multiple permafrost-thaw cycles since the initiation of permafrost at the site. At thaw features, the balance between increased primary production and higher CH4 emission stimulated by warmer temperatures and wetter conditions favors C sequestration and enhanced peat accumulation. Flux measurements suggest that frozen plateaus may intermittently (order of years to decades) act as CO2 sources depending on temperature and net ecosystem respiration rates, but modeling results suggest that—despite brief periods of net C loss to the atmosphere at the initiation of thaw—integrated over millennia, these sites have acted as net C sinks via peat accumulation. In greenhouse gas terms, the transition from frozen permafrost to thawed wetland is accompanied by increasing CO2 uptake that is partially offset by increasing CH4 emissions. In the short-term (decadal time scale) the net effect of this transition is likely enhanced warming via increased radiative C emissions, while in the long-term (centuries) net C deposition provides a negative feedback to climate warming

Just how long can you live in a black hole and what can be done about it?

We study the problem of how long a journey within a black hole can last. Based on our observations, we make two conjectures. First, for observers that have entered a black hole from an asymptotic region, we conjecture that the length of their journey within is bounded by a multiple of the future asymptotic ``size'' of the black hole, provided the spacetime is globally hyperbolic and satisfies the dominant-energy and non-negative-pressures conditions. Second, for spacetimes with ${\Bbb R}^3$ Cauchy surfaces (or an appropriate generalization thereof) and satisfying the dominant energy and non-negative-pressures conditions, we conjecture that the length of a journey anywhere within a black hole is again bounded, although here the bound requires a knowledge of the initial data for the gravitational field on a Cauchy surface. We prove these conjectures in the spherically symmetric case. We also prove that there is an upper bound on the lifetimes of observers lying ``deep within'' a black hole, provided the spacetime satisfies the timelike-convergence condition and possesses a maximal Cauchy surface. Further, we investigate whether one can increase the lifetime of an observer that has entered a black hole, e.g., by throwing additional matter into the hole. Lastly, in an appendix, we prove that the surface area $A$ of the event horizon of a black hole in a spherically symmetric spacetime with ADM mass $M_{\text{ADM}}$ is always bounded by $A \le 16\pi M_{\text{ADM}}^2$, provided that future null infinity is complete and the spacetime is globally hyperbolic and satisfies the dominant-energy condition.Comment: 20 pages, REVTeX 3.0, 6 figures included, self-unpackin

Recollapse of the closed Tolman spacetimes

The closed-universe recollapse conjecture is studied for the spherically symmetric spacetimes. It is proven that there exists an upper bound to the lengths of timelike curves in any Tolman spacetime that possesses $S^3$ Cauchy surfaces and whose energy density is positive. Furthermore, an explicit bound is constructed from the initial data for such a spacetime.Comment: 25 pages, REVTeX, NCSU-MP-930

Seed Treatment for Corn Diseases

In Iowa three destructive corn diseases attack the seed, namely, Dfplc·dfa dry rot, Baslsporlum dry rot and Gibberella dry rot. These dry rots are best known on the ear, but also may attack any part of the plant, lncluding the seed and seedling. The Injury to the seed and to the subsequent yield has been measured during the last six years in 25 counties and found to average 5 bushels per acre. These dry rot organisms llve over on the old stubble In the soil and on the seed and attack the next season\u27s crop

Temporal coherence, anomalous moments, and pairing correlations in the classical-field description of a degenerate Bose gas

The coherence properties of degenerate Bose gases have usually been expressed in terms of spatial correlation functions, neglecting the rich information encoded in their temporal behavior. In this paper we show, using a Hamiltonian classical-field formalism, that temporal correlations can be used to characterize familiar properties of a finite-temperature degenerate Bose gas. The temporal coherence of a Bose-Einstein condensate is limited only by the slow diffusion of its phase, and thus the presence of a condensate is indicated by a sharp feature in the temporal power spectrum of the field. We show that the condensate mode can be obtained by averaging the field for a short time in an appropriate phase-rotating frame, and that for a wide range of temperatures, the condensate obtained in this approach agrees well with that defined by the Penrose-Onsager criterion based on one-body (spatial) correlations. For time periods long compared to the phase diffusion time, the field will average to zero, as we would expect from the overall U(1) symmetry of the Hamiltonian. We identify the emergence of the first moment on short time scales with the concept of U(1) symmetry breaking that is central to traditional mean-field theories of Bose condensation. We demonstrate that the short-time averaging procedure constitutes a general analog of the 'anomalous' averaging operation of symmetry-broken theories by calculating the anomalous thermal density of the field, which we find to have form and temperature dependence consistent with the results of mean-field theories.Comment: 11 pages, 6 figures. v3: Final version. Typos fixed, and other minor change

A microscopic quantum dynamics approach to the dilute condensed Bose gas

We derive quantum evolution equations for the dynamics of dilute condensed Bose gases. The approach contains, at different orders of approximation, for cases close to equilibrium, the Gross Pitaevskii equation and the first order Hartree Fock Bogoliubov theory. The proposed approach is also suited for the description of the dynamics of condensed gases which are far away from equilibrium. As an example the scattering of two Bose condensates is discussed.Comment: 8 pages, submitted to Phys. Rev.