The Rise, Progress and Decline of the Quaker Movement in Scotland

The materials for a study of the Quaker Movement in Scotland in its historical setting and background have existed until the present time in multifarious manuscripts, records, pamphlets, books, and other scattered sources of various kinds. The object of the present Thesis is to collate these into a systematic and critical history of the rise, progress, and decline of the Society in Scotland, and to attempt some estimatfe of its place in Scottish religion. It has not always been easy to draw the line of demarcation between the Movement itself and the historical Theology connected with it, and the writer feels that in the latter field, useful research might be undertaken in such theological subjects as "The Westminster Confession of Faith and Scottish Quaker Theology of the 17th Century," or "The Contribution of Historical Quaker Theology to the Christian Dogmatic of to-day". It may seem that the Thesis is unusually long, and that the notes and references are too numerous, but in respect of the latter at least, the writer can only respectfully submit that in his judgement a pioneer work of this kind necessitates detailed documentation, if it is to serve the most useful purpose

Gastric emptying is slow in chronic fatigue syndrome

BACKGROUND: Gastrointestinal symptoms are common in patients with Chronic Fatigue Syndrome (CFS). The objective of this study was to determine the frequency of these symptoms and explore their relationship with objective (radionuclide) studies of upper GI function. METHODS: Thirty-two (32) patients with CFS and 45 control subjects completed a questionnaire on upper GI symptoms, and the 32 patients underwent oesophageal clearance, and simultaneous liquid and solid gastric emptying studies using radionuclide techniques compared with historical controls. RESULTS: The questionnaires showed a significant difference in gastric (p > 0.01) symptoms and swallowing difficulty. Nocturnal diarrhoea was a significant symptom not previously reported. 5/32 CFS subjects showed slightly delayed oesophageal clearance, but overall there was no significant difference from the control subjects, nor correlation of oesophageal clearance with symptoms. 23/32 patients showed a delay in liquid gastric emptying, and 12/32 a delay in solid gastric emptying with the delay significantly correlated with the mean symptom score (for each p ≪ 0.001). CONCLUSIONS: GI symptoms in patients with chronic fatigue syndrome are associated with objective changes of upper GI motility

Optical and Radio Polarimetry of the M87 Jet at 0.2" Resolution

We discuss optical (HST/WFPC2 F555W) and radio (15 GHz VLA) polarimetry observations of the M87 jet taken during 1994-1995. Many knot regions are very highly polarized ($\sim 40-50$, approaching the theoretical maximum for optically thin synchrotron radiation), suggesting highly ordered magnetic fields. High degrees of polarization are also observed in interknot regions. While the optical and radio polarization maps share many similarities, we observe significant differences between the radio and optical polarized structures, particularly for bright knots in the inner jet, giving us important insight into the jet's radial structure. Unlike in the radio, the optical magnetic field position angle becomes perpendicular to the jet at the upstream ends of knots HST-1, D, E and F. Moreover, the optical polarization decreases markedly at the position of the flux maxima in these knots. In contrast, the magnetic field position angle observed in the radio remains parallel to the jet in most of these regions, and the decreases in radio polarization are smaller. More minor differences are seen in other jet regions. Many of the differences between optical and radio polarimetry results can be explained in terms of a model whereby shocks occur in the jet interior, where higher-energy electrons are concentrated and dominate both polarized and unpolarized emissions in the optical, while the radio maps show strong contributions from lower-energy electrons in regions with {\bf B} parallel, near the jet surface.Comment: 28 pages, 7 figures; accepted for publication in AJ (May 1999

CERN Proton Synchrotron working point control using an improved version of the pole-face-windings and figure-of-eight loop powering

The working point of the CERN Proton Synchrotron, which is equipped with combined function magnets, is controlled using pole-face-windings. Each main magnet consists of one focusing and one de-focusing half-unit on which four pole-face-winding plates are mounted containing two separate coils each, called narrow and wide. At present they are connected in series, but can be powered independently. In addition, a winding called the figure-of-eight loop, contours the pole faces and crosses between the two half units, generating opposite fields in each half-unit. The four optical parameters, horizontal and vertical tune and chromaticity, are adjusted by acting on the pole-face-winding currents in both half units and in the figure-of-eight loop, leaving one physical quantity free. The power supply consolidation project opened the opportunity to use five independent power supplies, to adjust the four parameters plus an additional degree of freedom. This paper presents the results of the measurements that have been made in the five-current mode together with the influence of the magnetic nonlinearities, due to the unbalance in the narrow and wide winding currents, on the beam dynamics

Evaluation of poly (ADP-ribose) polymerase inhibitor ABT-888 combined with radiotherapy and temozolomide in glioblastoma.

BACKGROUND: The cytotoxicity of radiotherapy and chemotherapy can be enhanced by modulating DNA repair. PARP is a family of enzymes required for an efficient base-excision repair of DNA single-strand breaks and inhibition of PARP can prevent the repair of these lesions. The current study investigates the trimodal combination of ABT-888, a potent inhibitor of PARP1-2, ionizing radiation and temozolomide(TMZ)-based chemotherapy in glioblastoma (GBM) cells. METHODS: Four human GBM cell lines were treated for 5 h with 5 μM ABT-888 before being exposed to X-rays concurrently with TMZ at doses of 5 or 10 μM for 2 h. ABT-888's PARP inhibition was measured using immunodetection of poly(ADP-ribose) (pADPr). Cell survival and the different cell death pathways were examined via clonogenic assay and morphological characterization of the cell and cell nucleus. RESULTS: Combining ABT-888 with radiation yielded enhanced cell killing in all four cell lines, as demonstrated by a sensitizer enhancement ratio at 50% survival (SER50) ranging between 1.12 and 1.37. Radio- and chemo-sensitization was further enhanced when ABT-888 was combined with both X-rays and TMZ in the O6-methylguanine-DNA-methyltransferase (MGMT)-methylated cell lines with a SER50 up to 1.44. This effect was also measured in one of the MGMT-unmethylated cell lines with a SER50 value of 1.30. Apoptosis induction by ABT-888, TMZ and X-rays was also considered and the effect of ABT-888 on the number of apoptotic cells was noticeable at later time points. In addition, this work showed that ABT-888 mediated sensitization is replication dependent, thus demonstrating that this effect might be more pronounced in tumour cells in which endogenous replication lesions are present in a larger proportion than in normal cells. CONCLUSIONS: This study suggests that ABT-888 has the clinical potential to enhance the current standard treatment for GBM, in combination with conventional chemo-radiotherapy. Interestingly, our results suggest that the use of PARP inhibitors might be clinically significant in those patients whose tumour is MGMT-unmethylated and currently derive less benefit from TMZ.RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display the work; make derivative works; or make commercial use of the work - under the following conditions: the original author must be given credit; for any reuse or distribution, it must be made clear to others what the license terms of this work are