Synthetic Routes to a Library of Novel Methionine Synthase Inhibitors

Fungal infections are of continuous concern, especially with regard to immunocompromised patients. In an effort to develop new potential anti-fungal agents, we have begun synthesizing a library of potential inhibitors of the fungal Methionine Synthase (MetSyn) enzyme. Key differences between the B12-independant fungal MetSyn enzyme and the B12-dependant mammalian form can allow for an antifungal drug to be developed to exclusively bind the fungal enzyme and inhibit fungal growth while leaving the host (patient) unaffected. We are currently exploring the synthesis of various pterin and deazaguanine-based molecules as these mimic folate, an essential substrate for MetSyn function. We have begun testing these new molecules for activity in a fungal growth assay, as well as a fluorescent assay for monitoring MetSyn activity

Synthetic Routes to a Library of Novel Methionine Synthase Inhibitors

Fungal infections are of continuous concern, especially with regard to immunocompromised patients. In an effort to develop new potential anti-fungal agents, we have begun synthesizing a library of potential inhibitors of the fungal Methionine Synthase (MetSyn) enzyme. Key differences between the B12-independant fungal MetSyn enzyme and the B12-dependant mammalian form can allow for an antifungal drug to be developed to exclusively bind the fungal enzyme and inhibit fungal growth while leaving the host (patient) unaffected. We are currently exploring the synthesis of various pterin and deazaguanine-based molecules as these mimic folate, an essential substrate for MetSyn function. We have begun testing these new molecules for activity in a fungal growth assay, as well as a fluorescent assay for monitoring MetSyn activity

The Grizzly, November 24, 1992

Demas\u27s Furious Presentation • Possibility of AIDS Quilt at Ursinus • Lewis Receives the Muhlenberg Award • Share the Season • Clergy Assembly Held At U.C. • Senior Profile: Rick Naratil • Concert Band and Jazz Ensemble Perform Fall Concert • Messiah Tickets • Denis Leary\u27s No Cure For Cancer Breath of Fresh Air • Libo Speaks on Voyages to Freedom Exhibit • The Pointlessness of Political Correctness • Letters: Clark Responds to Christ on Campus ; Handicapped Accessibility: A Response From Someone Who Knows • Bears Basketball Buckles Under • Cross-Country Finishes Unbeaten Seasonhttps://digitalcommons.ursinus.edu/grizzlynews/1306/thumbnail.jp

The Grizzly, November 17, 1992

Ann Landers at Founder\u27s Day • Dr. Clayton Speaks on Education • An Active MSU • Elliot Speaks on Racism • Dinosaurs and Meteors • What Wismer Can Do For You • Greeks Grow With Chi Rho Psi • Top Ten Reasons Ursinus Needs a Coffeehouse • Catch of the Week • Shoulder Dancing to Depeche Mode • Voyages to Freedom Exhibit and the Jewish Experience in America • Messiah • In Their Own Words • Let\u27s See How They Like It • Concert and Jazz Bands to Perform • A Push for Physically Challenged Accessibility • Who\u27s on First? • Letters to the Editor • The Editorial Mission: Our Relationship to The Grizzly • UC Men\u27s Basketball For \u2792-\u2793 • Senior Billitto Glad He Transferred to UC • Field Hockey \u2792: A Look Back • Football Ends Tough Yearhttps://digitalcommons.ursinus.edu/grizzlynews/1305/thumbnail.jp

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

CMB-S4

We describe the stage 4 cosmic microwave background ground-based experiment CMB-S4

A Prognostic Method for Scheduling Maintenance on the P2- Marx Modulator

The SLAC National Accelerator Laboratory is developing a second generation Marx-type modulator for the ILC, the P2-Marx. The modulator is expected to operate reliably in excess of 10{sup 5} hours with minimum downtime. A prognostic system is being implemented with the development of the P2-Marx to monitor and track the health of key high voltage components. This paper discusses the way in which the prognostic system will be implemented and used to monitor the health of the P2-Marx modulator

Status Update on the Second-Generation ILC Marx Modulator Prototype

This paper is a status update of the SLAC P2 Marx. This Marx-topology klystron modulator is a second-generation modulator which builds upon experience gained from the SLAC P1 Marx. There are several fundamental differences between these modulators including the correction scheme, bus voltages, and the control system architecture. These differences, along with preliminary experimental results and the schedule for further development, are detailed in this paper

ILC MARX MODULATOR DEVELOPMENT PROGRAM STATUS

A Marx-topology klystron modulator is under development for the International Linear Collider (ILC) project. It is envisioned as a lower cost, smaller footprint, and higher reliability alternative to the present, bouncer-topology, baseline design. The application requires 120 kV (+/-0.5%), 140 A, 1.6 ms pulses at a rate of 5 Hz. The Marx constructs the high voltage pulse by combining, in series, a number of lower voltage cells. The Marx employs solid state elements; IGBTs and diodes, to control the charge, discharge and disolation of the cells. Active compensation of the output is used to achieve the voltage regulation while minimizing the stored energy. The developmental testing of a first generation prototype, P1, has been completed. This modulator has been integrated into a test stand with a 10 MW L-band klystron, where each is undergoing life testing. Development of a second generation prototype, P2, is underway. The P2 is based on the P1 topology but incorporates an alternative cell configuration to increase redundancy and improve availability. Status updates for both prototypes are presented

GaAs MOEMS Technology

Many MEMS-based components require optical monitoring techniques using optoelectronic devices for converting mechanical position information into useful electronic signals. While the constituent piece-parts of such hybrid opto-MEMS components can be separately optimized, the resulting component performance, size, ruggedness and cost are substantially compromised due to assembly and packaging limitations. GaAs MOEMS offers the possibility of monolithically integrating high-performance optoelectronics with simple mechanical structures built in very low-stress epitaxial layers with a resulting component performance determined only by GaAs microfabrication technology limitations. GaAs MOEMS implicitly integrates the capability for radiation-hardened optical communications into the MEMS sensor or actuator component, a vital step towards rugged integrated autonomous microsystems that sense, act, and communicate. This project establishes a new foundational technology that monolithically combines GaAs optoelectronics with simple mechanics. Critical process issues addressed include selectivity, electrochemical characteristics, and anisotropy of the release chemistry, and post-release drying and coating processes. Several types of devices incorporating this novel technology are demonstrated