16 research outputs found
Hepatoprotective effects of BPC-157 - paracetamol overdose
Paracetamol, also known as acetaminophen, is a widely used medication to treat pain and fever. As itās one of the over-the-counter medications, itās
easily accessible to everyone. Its mechanism of action is the inhibition of prostaglandin synthesis in the CNS to reduce hyperalgesia. It also influences the thermoregulatory center in the hypothalamus and lowers fever. 90-95% of paracetamol is metabolized in the liver where itās conjugated with glucuronic acid and sulfates into inactive metabolites, and the rest via cytochrome-p450. Its main side effect is hepatotoxicity and acute liver injury. Here we investigate the hepatoprotective effects of BPC-157 while administering a toxic dose of paracetamol intraperitoneally in rats
The effects of a varying doses of pilocarpine and lithium induced status epilepticus, and treatment with BPC-157
Peptadecapeptide BPC -157 has been reported to have a large spectrum of in vivo activities, from anti-ulcer to central action on the brain dopaminergic system, in addition to the aforementioned, BPC-157 might counteract standard convulsant induced seizures, insulin-, paracetamol-, alcohol withdrawal- and serotonin-syndrome-induced convulsion. The pilocarpine model of temporal lobe epilepsy uses a cholinomimetic convulsant, pilocarpine, to induce status epilepticus; as a result, hippocampal damage occurs thus resulting in the development of spontaneous recurrent seizures. In rats, pilocarpine can be administered with lithium, thus significantly reducing the pilocarpine dose required to induce status epilepticus and resulting in a higher percentage of animals developing status epilepticus
Effect of Pentadecapeptide BPC 157 on Hypercalcaemia in Rats
Isolated from gastric juice stable pentadecapeptide BPC 157 has already shown cytoprotective and organoprotective properties. Beneficial effects of BPC 157 on various organic systems such as cardiovascular, digestive, skeletomuscular system have already been proven. Focus of this research is hypercalcaemia and its effects on general function of the organism, ECG and haemodynamic and their presentation after BPC 157 administration
Strengthening Resilience of Preschool Children throughPreschool Institution
Temeljni cilj ovoga rada je steÄi uvid u otpornost djece te na koji naÄin predÅ”kolska ustanova može pridonijeti jaÄanju djeÄje otpornosti. Kao uvod u temu, opÅ”irno je definiran sam pojam otpornosti te opisan mentalni sklop otpornog djeteta. Zatim su nabrojani brojni riziÄni i zaÅ”titni Äimbenici Äija interakcija ima odluÄujuÄu ulogu u razvoju otpornosti. Ti se Äimbenici dijele na one unutarnje ā individualne te vanjske ā okolina. Postoje odreÄene skupine djece koje su ranjivije i ugroženije od ostalih te za koje je vjerojatnije da Äe razviti riziÄna ponaÅ”anja, a to su romska djeca, djeca izbjeglica i useljenika te djeca s posebnim potrebama. Kurikul otpornosti, o kojemu je rijeÄ u ovome radu, je osmiÅ”ljen kao univerzalan i inkluzivan program namijenjen svoj djeci, a posebice ranjivoj i ugroženoj. Teme i aktivnosti u ovome kurikulu odražavaju razliÄitost djece te se na taj naÄin potiÄe razvoj tolerancije i solidarnosti kod djece. U radu se istiÄe koliko je u djetetovu razvoju važna uloga odgajatelja koji mora pružati socijalnu i emocionalnu potporu. TakoÄer, naglasak se stavlja i na potrebu za suradnjom sustava koji su djetetu najbliži, a to su obitelj i odgojno-obrazovna ustanova. KljuÄni dio rada odnosi se na opis odgojno-obrazovnog okruženja koje je povoljno za poticanje otpornosti kod djece, a sastavnice takvog okruženja su sljedeÄe: brižni odnosi, kultura podrÅ”ke i solidarnosti, aktivni i iskreni angažman, inkluzija i uspjeh za sve, suradnja i timski rad te izbor i glas. TakoÄer, prikazan je jedan noviji pristup koji na otpornost gleda kao na jednu od Äetiri temeljne odrednice pozitivno oblikovana mozga, a ostale odrednice su empatija, ravnoteža i uviÄavnost.The basic objective of this paper is to gain insight to the resilience of children and how a preschool can contribute to strengthening children's resilience. As an introduction to the topic, the very concept of resilience is defined and the mental frame of a resilient child is described. Then, a number of risk and protective factors are listed, whose interaction plays a decisive role in the development of resilience. These factors are divided into those internal ā individual and external ā environment. There are certain groups of children who are more vulnerable and threatened than others and who are more likely to develop risky behaviors, such as Roma children, refugee and immigrant children and children with special needs. The Resilience curriculum discussed in this paper is designed as a universal and inclusive program intended for all children, especially the vulnerable and threatened. The topics and activities in this curriculum reflect the diversity of children and thus encourage the development of tolerance and solidarity in children. The paper emphasizes the importance of the role of the preschool teachers in the child's development, who must provide social and emotional support. Emphasis is also placed on the need for the cooperation of the systems closest to the child, which are the family and the educational institution. A key part of the paper concerns the description of an educational environment that is conducive to fostering resilience in children, and the components of such an environment are the following: caring relationships, a culture of support and solidarity, active and genuine engagement, inclusion and success for all, collaboration and teamwork and choice and voice. Also, a more recent approach is presented that views resilience as one of the four basic determinants of a positively shaped brain, while the other determinants are empathy, balance and insight
Means of the primary school pupils leisure pursuing
Cilj istraživanja bio je ispitati uÄenike treÄih i Äetvrtih razreda osnovne Å”kole o naÄinima provoÄenja slobodnog vremena, zadovoljstvo roditelja ponudom sadržaja u lokalnoj i regionalnoj zajednici te njihove prijedloge za poboljÅ”anje kvalitete slobodnog vremena djece. U istraživanju su sudjelovali uÄenici treÄih i Äetvrtih razreda i njihovi roditelji. Rezultati su pokazali da veÄina uÄenika sudjeluje u izvannastavnim aktivnostima i to najviÅ”e iz sportsko-rekreacijskog i jeziÄno-umjetniÄkog podruÄja te sudjeluju i u izvanÅ”kolskim aktivnostima u kojima prevladavaju sportovi kao Å”to su nogomet, odbojka, plivanje, gimnastika i sl. UÄenici se u slobodno vrijeme najviÅ”e vole igrati s prijateljima/prijateljicama, a najdraža aktivnost s prijateljima je igra. Na skali od 1 do 10 uÄenici su veÄinom odabrali da igrice na raÄunalu i mobitelu vole 5, a najdraža aktivnost s obitelji je Å”etnja. Nadalje, prema odgovorima roditelja može se zakljuÄiti da roditelji nisu sasvim zadovoljni ponudom u lokalnoj i regionalnoj zajednici te bi se na temelju prijedloga roditelja trebalo poraditi na raznovrsnosti ponude Å”to se tiÄe aktivnosti i sadržaja za djecu i prostorima za održavanje aktivnosti kao Å”to su to dvorane, igraliÅ”ta i centri. IzmeÄu ostalog, jedan od prijedloga su i radionice s roditeljima kako bi se stvorila i ojaÄala komunikacija izmeÄu Å”kole i roditelja te kroz izlete, pokretanje zadataka, projekata i druÅ”tveno odgovornih akcija.The aim of the research was to examine the third and fourth graders of elementary school about the ways of spending their free time, parents' satisfaction with the content offered in the local and regional community, and their suggestions for improving the quality of children's free time. Third and fourth grade students and their parents participated in the research. The results showed that most students participate in extracurricular activities, mostly in the sports-recreational and language-artistic fields, and they also participate in out-of-school activities in which sports such as football, volleyball, swimming, gymnastics, etc. predominate. In their free time, students mostly like to play with friends, and their favorite activity with friends is playing. On a scale from 1 to 10, most students chose that they like computer and cell phone games at 5, and their favorite activity with their family is going for a walk. Furthermore, according to the parents' answers, it can be concluded that parents are not completely satisfied with the offer in the local and regional community, and based on the parents' suggestions, work should be done on the diversity of the offer in terms of activities and content for children and spaces for holding activities such as gyms, playgrounds, and centers. Among other things, one of the suggestions are workshops with parents to create and strengthen communication between the school and parents through trips, starting tasks, projects, and socially responsible actions
Prevencija i fizioterapija najÄeÅ”Äih ozljeda u rukometu
KombinirajuÄi brzinu, snagu, izdržljivost, agilnost, tehniÄku preciznost, vjeÅ”tinu i timski
rad, rukomet je postao jedan od najbržih i najuzbudljivijih olimpijskih sportova. Rukomet
karakterizira intenzivan kontakt tijela, Äesto isprekidano trÄanje, zahtjevne situacije jedan na
jedan, brze promjene smjera u kombinaciji s izazovnom tehnikom i elementima koordinacije
poput hvatanja, bacanja, dodavanja i driblinga. VeÄina ozljeda dogaÄa se tijekom utakmica,
posebice u situacijama jedan na jedan, tj. tjelesnim kontaktom. NajviŔe je ozljeda donjih
ekstremiteta, zatim ozljeda glave i gornjih ekstremiteta. Pokazalo se da vježbe
neuromuskularnog zagrijavanja sprjeÄavaju ozljede. U biti, neuromuskularno zagrijavanje je
oblik vježbe koji trenira živce i miÅ”iÄe da bolje reagiraju i komuniciraju. Zagrijavanje
ukljuÄuju izvoÄenje vježbi nižim intenzitetom i sporijim tempom, Å”to poboljÅ”ava sportsku
izvedbu, sprjeÄava ozljede i pomaže u oporavku. Zagrijavanje u biti govori tijelu da se
pripremi za vježbu s laganim intenzitetom ili laganim pokretima. Prevencija ozljeda trebala bi
biti važan dio svake tjelesne aktivnosti jer ne samo da pomaže u postizanju ciljeva treninga,
veÄ takoÄer održava osobu zdravom i sigurnom
The relationship of parents' well-being with children's resilience
Tema ovog diplomskog rada je povezanost dobrobiti roditelja s psiholoŔkom
otpornosti djece. Ciljevi rada bili su ispitati povezanost dobrobiti roditelja (sreÄa i životno
zadovoljstvo) s psiholoŔkom otpornosti djece te ispitati koje od uzetih varijabli (dob, stupanj
obrazovanja, broj djece, COVID-19 kriza i potresi) su povezane s otpornosti roditelja.
Istraživanje je provedeno na uzorku od 225 ispitanika, roditelja djece u dobi od 2 do 7 godina.
Podatci za potrebe istraživanja prikupljeni su tijekom svibnja i lipnja 2021. godine putem online upitnika. Glavni dio upitnika sastojao se od dva veÄ postojeÄa upitnika: Connor-Davidson
skala otpornosti od 10 Äestica i Mjera otpornosti djece i mladih ā revidirana verzija za
najupuÄeniju osobu. Osim toga, ispitane su sociodemografske karakteristike roditelja te su
prikupljeni podatci o sreÄi, zadovoljstvu životom, razini stresa u protekloj godini te utjecaju
COVID-19 krize i potresa na roditelje.
Rezultati dobiveni istraživanjem upuÄuju na pozitivnu povezanost izmeÄu psiholoÅ”ke
otpornosti roditelja i njihove djece, kao i na pozitivnu povezanost izmeÄu sreÄe i životnog
zadovoljstva roditelja te otpornosti njihove djece. Nadalje, pokazalo se da ne postoji
povezanost izmeÄu otpornosti roditelja te sljedeÄih varijabli: dob roditelja, stupanj
obrazovanja, broj djece, potresi. MeÄutim, potvrÄena je pretpostavka da Äe roditelji veÄe
psiholoŔke otpornosti doživjeti COVID-19 krizu manje stresno nego roditelji slabije
psiholoŔke otpornosti.The aim of this paper is the relationship of parents' well-being with children's
resilience. The objectives of this research were to examine the relationship between wellbeing of parents (happiness and life satisfaction) and psychological resilience of children and
to examine which of the taken variables (age, level of education, number of children, COVID19 crisis and earthquakes) were related to parental resilience. The research was conducted on
a sample of 225 respondents, parents of children aged 2 to 7 years. Data for the purposes of
the research was collected during May and June 2021 through an online questionnaire. The
main part of the questionnaire consisted of two pre-existing questionnaires: The 10-item
Connor-Davidson Resilience Scale and The Child and Youth Resilience Measure ā Revised
Person Most Knowledgeable version. In addition, the sociodemographic characteristics of
parents were examined and data on happiness, life satisfaction, stress levels in the past year
and the impact of the COVID-19 crisis and earthquake on parents was collected.
The results obtained by the research suggest a positive correlation between the
psychological resilience of parents and their children, as well as the positive correlation
between happiness and life satisfaction of parents and the resilience of their children.
Furthermore, there was no correlation between parental resilience and the following variables:
parental age, education level, number of children, earthquakes. However, the hypothesis was
confirmed that parents of higher psychological resilience would experience the COVID-19
crisis less stressfully than parents of weaker psychological resilience
Means of the primary school pupils leisure pursuing
Cilj istraživanja bio je ispitati uÄenike treÄih i Äetvrtih razreda osnovne Å”kole o naÄinima provoÄenja slobodnog vremena, zadovoljstvo roditelja ponudom sadržaja u lokalnoj i regionalnoj zajednici te njihove prijedloge za poboljÅ”anje kvalitete slobodnog vremena djece. U istraživanju su sudjelovali uÄenici treÄih i Äetvrtih razreda i njihovi roditelji. Rezultati su pokazali da veÄina uÄenika sudjeluje u izvannastavnim aktivnostima i to najviÅ”e iz sportsko-rekreacijskog i jeziÄno-umjetniÄkog podruÄja te sudjeluju i u izvanÅ”kolskim aktivnostima u kojima prevladavaju sportovi kao Å”to su nogomet, odbojka, plivanje, gimnastika i sl. UÄenici se u slobodno vrijeme najviÅ”e vole igrati s prijateljima/prijateljicama, a najdraža aktivnost s prijateljima je igra. Na skali od 1 do 10 uÄenici su veÄinom odabrali da igrice na raÄunalu i mobitelu vole 5, a najdraža aktivnost s obitelji je Å”etnja. Nadalje, prema odgovorima roditelja može se zakljuÄiti da roditelji nisu sasvim zadovoljni ponudom u lokalnoj i regionalnoj zajednici te bi se na temelju prijedloga roditelja trebalo poraditi na raznovrsnosti ponude Å”to se tiÄe aktivnosti i sadržaja za djecu i prostorima za održavanje aktivnosti kao Å”to su to dvorane, igraliÅ”ta i centri. IzmeÄu ostalog, jedan od prijedloga su i radionice s roditeljima kako bi se stvorila i ojaÄala komunikacija izmeÄu Å”kole i roditelja te kroz izlete, pokretanje zadataka, projekata i druÅ”tveno odgovornih akcija.The aim of the research was to examine the third and fourth graders of elementary school about the ways of spending their free time, parents' satisfaction with the content offered in the local and regional community, and their suggestions for improving the quality of children's free time. Third and fourth grade students and their parents participated in the research. The results showed that most students participate in extracurricular activities, mostly in the sports-recreational and language-artistic fields, and they also participate in out-of-school activities in which sports such as football, volleyball, swimming, gymnastics, etc. predominate. In their free time, students mostly like to play with friends, and their favorite activity with friends is playing. On a scale from 1 to 10, most students chose that they like computer and cell phone games at 5, and their favorite activity with their family is going for a walk. Furthermore, according to the parents' answers, it can be concluded that parents are not completely satisfied with the offer in the local and regional community, and based on the parents' suggestions, work should be done on the diversity of the offer in terms of activities and content for children and spaces for holding activities such as gyms, playgrounds, and centers. Among other things, one of the suggestions are workshops with parents to create and strengthen communication between the school and parents through trips, starting tasks, projects, and socially responsible actions
The relationship of parents' well-being with children's resilience
Tema ovog diplomskog rada je povezanost dobrobiti roditelja s psiholoŔkom
otpornosti djece. Ciljevi rada bili su ispitati povezanost dobrobiti roditelja (sreÄa i životno
zadovoljstvo) s psiholoŔkom otpornosti djece te ispitati koje od uzetih varijabli (dob, stupanj
obrazovanja, broj djece, COVID-19 kriza i potresi) su povezane s otpornosti roditelja.
Istraživanje je provedeno na uzorku od 225 ispitanika, roditelja djece u dobi od 2 do 7 godina.
Podatci za potrebe istraživanja prikupljeni su tijekom svibnja i lipnja 2021. godine putem online upitnika. Glavni dio upitnika sastojao se od dva veÄ postojeÄa upitnika: Connor-Davidson
skala otpornosti od 10 Äestica i Mjera otpornosti djece i mladih ā revidirana verzija za
najupuÄeniju osobu. Osim toga, ispitane su sociodemografske karakteristike roditelja te su
prikupljeni podatci o sreÄi, zadovoljstvu životom, razini stresa u protekloj godini te utjecaju
COVID-19 krize i potresa na roditelje.
Rezultati dobiveni istraživanjem upuÄuju na pozitivnu povezanost izmeÄu psiholoÅ”ke
otpornosti roditelja i njihove djece, kao i na pozitivnu povezanost izmeÄu sreÄe i životnog
zadovoljstva roditelja te otpornosti njihove djece. Nadalje, pokazalo se da ne postoji
povezanost izmeÄu otpornosti roditelja te sljedeÄih varijabli: dob roditelja, stupanj
obrazovanja, broj djece, potresi. MeÄutim, potvrÄena je pretpostavka da Äe roditelji veÄe
psiholoŔke otpornosti doživjeti COVID-19 krizu manje stresno nego roditelji slabije
psiholoŔke otpornosti.The aim of this paper is the relationship of parents' well-being with children's
resilience. The objectives of this research were to examine the relationship between wellbeing of parents (happiness and life satisfaction) and psychological resilience of children and
to examine which of the taken variables (age, level of education, number of children, COVID19 crisis and earthquakes) were related to parental resilience. The research was conducted on
a sample of 225 respondents, parents of children aged 2 to 7 years. Data for the purposes of
the research was collected during May and June 2021 through an online questionnaire. The
main part of the questionnaire consisted of two pre-existing questionnaires: The 10-item
Connor-Davidson Resilience Scale and The Child and Youth Resilience Measure ā Revised
Person Most Knowledgeable version. In addition, the sociodemographic characteristics of
parents were examined and data on happiness, life satisfaction, stress levels in the past year
and the impact of the COVID-19 crisis and earthquake on parents was collected.
The results obtained by the research suggest a positive correlation between the
psychological resilience of parents and their children, as well as the positive correlation
between happiness and life satisfaction of parents and the resilience of their children.
Furthermore, there was no correlation between parental resilience and the following variables:
parental age, education level, number of children, earthquakes. However, the hypothesis was
confirmed that parents of higher psychological resilience would experience the COVID-19
crisis less stressfully than parents of weaker psychological resilience