An oscillatory interference model of grid cell firing

We expand upon our proposal that the oscillatory interference mechanism proposed for the phase precession effect in place cells underlies the grid-like firing pattern of dorsomedial entorhinal grid cells (O'Keefe and Burgess (2005) Hippocampus 15:853-866). The original one-dimensional interference model is generalized to an appropriate two-dimensional mechanism. Specifically, dendritic subunits of layer 11 medial entorhinal stellate cells provide multiple linear interference patterns along different directions, with their product determining the firing of the cell. Connection of appropriate speed- and direction- dependent inputs onto dendritic subunits could result from an unsupervised learning rule which maximizes postsynaptic firing (e.g. competitive learning). These inputs cause the intrinsic oscillation of subunit membrane potential to. increase above theta frequency by an amount proportional to the animal's speed of running in the "preferred" direction. The phase difference between this oscillation and a somatic input at theta-frequency essentially integrates velocity so that the interference of the two oscillations reflects distance traveled in the preferred direction. The overall grid pattern is maintained in environmental location by phase reset of the grid cell by place cells receiving sensory input from the environment, and environmental boundaries in particular. We also outline possible variations on the basic model, including the generation of grid-like firing via the interaction of multiple cells rather than via multiple dendritic subunits. Predictions of the interference model are given for the frequency composition of EEG power spectra and temporal autocorrelograms of grid cell firing as functions of the speed and direction of running and the novelty of the environment. (C) 2007 Wiley-Liss, Inc

Theta-modulated place-by-direction cells in the hippocampal formation in the rat

We report the spatial and temporal properties of a class of cells termed theta-modulated place-by-direction (TPD) cells recorded from the presubicular and parasubicular cortices of the rat. The firing characteristics of TPD cells in open-field enclosures were compared with those of the following two other well characterized cell classes in the hippocampal formation: place and head-direction cells. Unlike place cells, which code only for the animal's location, or head-direction cells, which code only for the animal's directional heading, TPD cells code for both the location and the head direction of the animal. Their firing is also strongly theta modulated, firing primarily at the negative-to-positive phase of the locally recorded theta wave. TPD theta modulation is significantly stronger than that of place cells. In contrast, the firing of head-direction cells is not modulated by theta at all. In repeated exposures to the same environment, the locational and directional signals of TPD cells are stable. When recorded in different environments, TPD locational and directional fields can uncouple, with the locational field shifting unpredictably ("remapping"), whereas the directional preference remains similar across environments

A comparison of the responses of mature and young clonal tea to drought.

To assist commercial producers with optimising the use of irrigation water, the responses to drought of mature and young tea crops (22 and 5 years after field planting respectively) were compared using data from two adjacent long-term irrigation experiments in Southern Tanzania. Providing the maximum potential soil water deficit was below about 400-500 mm for mature, and 200-250 mm for young plants (clone 6/8), annual yields of dry tea from rainfed or partially irrigated crops were similar to those from the corresponding well-watered crops. At deficits greater than this, annual yields declined rapidly in young tea (up to 22 kg (ha mm)-1) but relatively slowly in mature tea (up to 6.5 kg (ha mm)- 1). This apparent insensitivity of the mature crop to drought was due principally to compensation that occurred during the rains for yield lost in the dry season. Differences in dry matter distribution and shoot to root ratios contributed to these contrasting responses. Thus, the total above ground dry mass of well-irrigated, mature plants was about twice that for young plants. Similarly, the total mass of structural roots (>1 mm diameter), to 3 m depth, was four times greater in the mature crop than in the young crop and, for fine roots (<1 mm diameter), eight times greater. The corresponding shoot to root ratios (dry mass) were about 1:1 and 2:1 respectively. In addition, each unit area of leaf in the canopy of a mature plant had six times more fine roots (by weight) available to extract and supply water than did a young plant. Despite the logistical benefits resulting from more even crop distribution during the year when crops are fully irrigated, producers currently prefer to save water and energy costs by allowing a substantial soil water deficit to develop prior to the start of the rains, up to 250 mm in mature tea, knowing that yield compensation will occur later

Clinical trials in South Africa : need for capacity building and training

The original publication is available at http://www.samj.org.zaPublishers' Versio

Clinical trials in South Africa : need for capacity building and training

The original publication is available at http://www.samj.org.zaPublishers' Versio

Cosmology and Static Spherically Symmetric solutions in D-dimensional Scalar Tensor Theories: Some Novel Features

We consider scalar tensor theories in D-dimensional spacetime, D \ge 4. They consist of metric and a non minimally coupled scalar field, with its non minimal coupling characterised by a function. The probes couple minimally to the metric only. We obtain vacuum solutions - both cosmological and static spherically symmetric ones - and study their properties. We find that, as seen by the probes, there is no singularity in the cosmological solutions for a class of functions which obey certain constraints. It turns out that for the same class of functions, there are static spherically symmetric solutions which exhibit novel properties: {\em e.g.} near the ``horizon'', the gravitational force as seen by the probe becomes repulsive.Comment: Revtex. 21 pages. Version 2: More references added. Version 3: Issues raised by the referee are addressed. Results unchanged. Title modified; a new subsection and more references added. Verison to appear in Physical Review

Braneworld inflation

We discuss various realizations of the four dimensional braneworld inflation in warped geometries of string theory. In all models the inflaton field is represented by a Dp probe brane scalar specifying its position in the warped throat of the compactification manifold. We study existing inflationary throat local geometries, and construct a new example. The inflationary brane is either a D3- or a D5-brane of type IIB string theory. In the latter case the inflationary brane is wrapping a two-cycle of the compactification manifold. We discuss some phenomenological aspects of the model where slow-roll conditions are under computational control.Comment: 31 pages + 6 figures, v2: published PRD versio