Student outcomes from diverse undergraduate research experiences - findings from a multi-disciplinary study

Undergraduate research experiences (UREs) provide students with opportunities to engage in high impact experiential learning. UREs have been especially prevalent in the sciences, but there are now extensive banks of case studies demonstrating the use of UREs as an educationally enriching activity in nearly all disciplines. This study investigated the diversity of UREs available across a wide range of disciplines at a large Australian research-intensive university and examined the perceived benefits. Through group interviews with 68 academics, we gathered detailed information about 81 URE activities, across 28 Schools within the institution (representing 77.8% of Schools), ranging from archaeology to political science, from biology to social work and from law to journalism. The most common URE model observed was that of activities embedded in courses. Across disciplines the most common feature was the requirement for students to engage with the research literature in their field. A smaller number of models incorporated features which allowed students to engage in other high impact learning activities such as community-based activities and internships. Although we identified a large ‘set’ of perceived student outcomes across the varied URE models the generic graduate attributes attained by students through these UREs appeared to be independent of the discipline itself. In most cases, the UREs were available to all students rather than an elite or specialist cohort. This leads us to believe that across a range of disciplinary contexts, there are many ways to use UREs to achieve high levels of engagement of large cohorts of students

The competitive NMDA antagonist CPP protects substantia nigra neurons from MPTP-induced degeneration in primates

Degeneration of nigrostriatal dopaminergic neurons is the primary histopathological feature of Parkinson's disease. The neurotoxin MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) induces a neurological syndrome in man and non-human primates very similar to idiopathic Parkinson's disease by selectively destroying dopaminergic nigrostriatal neurons. This gives rise to the hypothesis that Parkinson's disease may be caused by endogenous or environmental toxins. Endogenous excitatory amino acids (EAAs) such as L-glutamate could be involved in neurodegenerative disorders including Parkinson's disease. We report in this study that the competitive NMDA antagonist CPP (3-((+/-)-2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid) protects nigral tyrosine hydroxylase (TH) positive neurons from degeneration induced by systemic treatment with MPTP in common marmosets. This indicates that EAAs are involved in the pathophysiological cascade of MPTP-induced neuronal cell death and that EAA antagonists may offer a neuroprotective therapy for Parkinson's disease

Asymptotic Conformal Yano--Killing Tensors for Schwarzschild Metric

The asymptotic conformal Yano--Killing tensor proposed in J. Jezierski, On the relation between metric and spin-2 formulation of linearized Einstein theory [GRG, in print (1994)] is analyzed for Schwarzschild metric and tensor equations defining this object are given. The result shows that the Schwarzschild metric (and other metrics which are asymptotically ``Schwarzschildean'' up to O(1/r^2) at spatial infinity) is among the metrics fullfilling stronger asymptotic conditions and supertranslations ambiguities disappear. It is also clear from the result that 14 asymptotic gravitational charges are well defined on the ``Schwarzschildean'' background.Comment: 8 pages, latex, no figure

Behavioral economics implementation: Regret lottery improves mHealth patient study adherence.

Background: Nonadherence to study protocols reduces the generalizability, validity, and statistical power of longitudinal studies. Purpose: To determine whether an automated electronically-delivered regret lottery would improve adherence to an intensive mHealth self-monitoring protocol as part of a longitudinal observational study. Methods: We enrolled 77 adults into a 52-week study requiring five daily ecologic momentary assessments (EMA) of stress and daily accelerometer use. We performed a pre/post single-arm study to evaluate the efficacy of a lottery intervention in improving adherence to this protocol. Midway through the study, participants were invited to enter a weekly regret lottery ($50 prize, expected value Results: 62 participants consented to lottery participation. In the 12 weeks prior to lottery initiation, weekly adherence was declining (slope -1.4%/week). The weekly per-participant probability of adherence was higher after lottery initiation when comparing the 4-week (32% pre-lottery vs 50% post-lottery, p \u3c 0.001), 8-week (37% vs 49%, p \u3c 0.001), and 12-week periods (39% vs 45%, p = 0.001) before and after lottery initiation. However, the rate of decline in adherence over time was unchanged. Conclusion: The implementation of an automated, electronically-delivered weekly regret lottery improved adherence with an intensive self-monitoring study protocol. Regret lotteries may represent a cost-effective tool to improve adherence and reduce bias caused by dropout or nonadherence

Recommendations for uniform definitions used in newborn screening for severe combined immunodeficiency

BACKGROUND: Public health newborn screening (NBS) programs continuously evolve, taking advantage of international shared learning. NBS for severe combined immunodeficiency (SCID) has recently been introduced in many countries. However, comparison of screening outcomes has been hampered by use of disparate terminology and imprecise or variable case definitions for non-SCID conditions with T-cell lymphopenia. OBJECTIVES: This study sought to determine whether standardized screening terminology could overcome a Babylonian confusion and whether improved case definitions would promote international exchange of knowledge. METHODS: A systematic literature review highlighted the diverse terminology in SCID NBS programs internationally. While, as expected, individual screening strategies and tests were tailored to each program, we found uniform terminology to be lacking in definitions of disease targets, sensitivity, and specificity required for comparisons across programs. RESULTS: The study’s recommendations reflect current evidence from literature and existing guidelines coupled with opinion of experts in public health screening and immunology. Terminologies were aligned. The distinction between actionable and nonactionable T-cell lymphopenia among non-SCID cases was clarified, the former being infants with T-cell lymphopenia who could benefit from interventions such as protection from infections, antibiotic prophylaxis, and live-attenuated vaccine avoidance. CONCLUSIONS: By bringing together the previously unconnected public health screening community and clinical immunology community, these SCID NBS deliberations bridged the gaps in language and perspective between these disciplines. This study proposes that international specialists in each disorder for which NBS is performed join forces to hone their definitions and recommend uniform registration of outcomes of NBS. Standardization of terminology will promote international exchange of knowledge and optimize each phase of NBS and follow-up care, advancing health outcomes for children worldwide

Toward the PSTN/Internet Inter-Networking--Pre-PINT Implementations

This document contains the information relevant to the development of the inter-networking interfaces underway in the Public Switched Telephone Network (PSTN)/Internet Inter-Networking (PINT) Working Group. It addresses technologies, architectures, and several (but by no means all) existing pre-PINT implementations of the arrangements through which Internet applications can request and enrich PSTN telecommunications services. The common denominator of the enriched services (a.k.a. PINT services) is that they combine the Internet and PSTN services in such a way that the Internet is used for non-voice interactions, while the voice (and fax) are carried entirely over the PSTN. One key observation is that the pre-PINT implementations, being developed independently, do not inter-operate. It is a task of the PINT Working Group to define the inter-networking interfaces that will support inter-operation of the future implementations of PINT services

Constraining q_0 with Cluster Gas Mass Fractions: A Feasibility Study

As the largest gravitationally bound objects in the universe, clusters of galaxies may contain a fair sample of the baryonic mass fraction of the universe. Since the gas mass fraction from the hot ICM is believed to be constant in time, the value of the cosmological deceleration parameter $q_0$ can be determined by comparing the calculated gas mass fraction in nearby and distant clusters (Pen 1997). To test the potential of this method, we compare the gas fractions derived for a sample of luminous ($L_X > 10^{45}$erg s$^{-1}$), nearby clusters with those calculated for eight luminous, distant ($0.3 < z < 0.6$) clusters using ASCA and ROSAT observations. For consistency, we evaluate the gas mass fraction at a fixed physical radius of 1 $h_{50}^{-1}$ Mpc (assuming $q_0=0.0$). We find a best fit value of $q_0 = 0.07$ with -0.47 < q_0 < 0.67 at 95% confidence. We also determine the gas fraction using the method of Evrard, Metzler, & Navarro (1997) to find the total mass within $r_{500}$, the radius where the mean overdensity of matter is 500 times the critical density. In simulations, this method reduces the scatter in the determination of gravitational mass without biasing the mean. We find that it also reduces the scatter in actual observations for nearby clusters, but not as much as simulations suggest. Using this method, the best fit value is $q_0 = 0.04$ with -0.50 < q_0 < 0.64. The excellent agreement between these two methods suggests that this may be a useful technique for determining $q_0$. The constraints on $q_0$ should improve as more distant clusters are studied and precise temperature profiles are measured to large radii.Comment: 8 pages, 4 figures, uses emulateapj.sty, onecolfloat.st

The Evolution of Environmental Quenching Timescales to z∼1.6z\sim1.6

Using a sample of 4 galaxy clusters at $1.35 < z < 1.65$ and 10 galaxy clusters at $0.85 < z < 1.35$, we measure the environmental quenching timescale, $t_Q$, corresponding to the time required after a galaxy is accreted by a cluster for it to fully cease star formation. Cluster members are selected by a photometric-redshift criterion, and categorized as star-forming, quiescent, or intermediate according to their dust-corrected rest-frame colors and magnitudes. We employ a "delayed-then-rapid" quenching model that relates a simulated cluster mass accretion rate to the observed numbers of each type of galaxy in the cluster to constrain $t_Q$. For galaxies of mass $M_* \gtrsim 10^{10.5}~ \mathrm{M}_\odot$, we find a quenching timescale of $t_Q=$ 1.24 Gyr in the $z\sim1.5$ cluster sample, and $t_Q=$ 1.50 Gyr at $z\sim1$. Using values drawn from the literature, we compare the redshift evolution of $t_Q$ to timescales predicted for different physical quenching mechanisms. We find $t_Q$ to depend on host halo mass such that quenching occurs over faster timescales in clusters relative to groups, suggesting that properties of the host halo are responsible for quenching high-mass galaxies. Between $z=0$ and $z=1.5$, we find that $t_Q$ evolves faster than the molecular gas depletion timescale and slower than an SFR-outflow timescale, but is consistent with the evolution of the dynamical time. This suggests that environmental quenching in these galaxies is driven by the motion of satellites relative to the cluster environment, although due to uncertainties in the atomic gas budget at high redshift, we cannot rule out quenching due to simple gas depletion