Plasmas in Saturn's magnetosphere

The solar wind plasma analyzer on board Pioneer 2 provides first observations of low-energy positive ions in the magnetosphere of Saturn. Measurable intensities of ions within the energy-per-unit charge (E/Q) range 100 eV to 8 keV are present over the planetocentric radial distance range about 4 to 16 R sub S in the dayside magnetosphere. The plasmas are found to be rigidly corotating with the planet out to distances of at least 10 R sub S. At radial distances beyond 10 R sub S, the bulk flows appear to be in the corotation direction but with lesser speeds than those expected from rigid corotation. At radial distances beyond the orbit of Rhea at 8.8 R sub S, the dominant ions are most likely protons and the corresponding typical densities and temperatures are 0.5/cu cm and 1,000,000 K, respectively, with substantial fluctuations. It is concluded that the most likely source of these plasmas in the photodissociation of water frost on the surface of the ring material with subsequent ionization of the products and radially outward diffusion. The presence of this plasma torus is expected to have a large influence on the dynamics of Saturn's magnetosphere since the pressure ratio beta of these plasmas approaches unity at radial distances as close to the planet as 6.5 R sub S. On the basis of these observational evidences it is anticipated that quasi-periodic outward flows of plasma, accompanied with a reconfiguration of the magnetosphere beyond about 6.5 R sub S, will occur in the local night sector in order to relieve the plasma pressure from accretion of plasma from the rings

Water Futures and Solution - Fast Track Initiative (Final Report)

The Water Futures and Solutions Initiative (WFaS) is a cross-sector, collaborative global water project. Its objective is to apply systems analysis, develop scientific evidence and identify water-related policies and management practices, working together consistently across scales and sectors to improve human well-being through water security. The approach is a stakeholder-informed, scenario-based assessment of water resources and water demand that employs ensembles of state-of-the-art socio-economic and hydrological models, examines possible futures and tests the feasibility, sustainability and robustness of options that can be implemented today and can be sustainable and robust across a range of possible futures and associated uncertainties. This report aims at assessing the global current and future water situation

Photon-mediated interactions between quantum emitters in a diamond nanocavity

Photon-mediated interactions between quantum systems are essential for realizing quantum networks and scalable quantum information processing. We demonstrate such interactions between pairs of silicon-vacancy (SiV) color centers coupled to a diamond nanophotonic cavity. When the optical transitions of the two color centers are tuned into resonance, the coupling to the common cavity mode results in a coherent interaction between them, leading to spectrally-resolved superradiant and subradiant states. We use the electronic spin degrees of freedom of the SiV centers to control these optically-mediated interactions. Such controlled interactions will be crucial in developing cavity-mediated quantum gates between spin qubits and for realizing scalable quantum network nodes

Mechanical characterisation of additively manufactured elastomeric structures for variable strain rate applications

Additive manufacturing (AM) enables production of geometrically-complex elastomeric structures. The elastic recovery and strain-rate dependence of these materials means they are ideal for use in dynamic, repetitive mechanical loading. Their process-dependence, and the frequent emergence of new AM elastomers, commonly necessitates full material characterisation; however, accessing specialised equipment means this is often a time-consuming and expensive process. This work presents an innovative equi-biaxial rig that enables full characterisation via just a conventional material testing machine (supplementing uni-axial tension and planar tension tests). Combined with stress relaxation data, this provides a novel route for hyperelastic material modelling with viscoelastic components. This approach was validated by recording the force-displacement and deformation histories from finite element modelling a honeycomb structure. These data compared favourably to experimental quasistatic and dynamic compression testing, validating this novel and convenient route for characterising complex elastomeric materials. Supported by data describing the potential for high build-quality production using an AM process with low barriers to entry, this study should serve to encourage greater exploitation of this emerging manufacturing process for fabricating elastomeric structures within industrial communities.M. Robinson was supported by the Knowledge Economy Skills Scholarships 2 (via the Welsh Government’s European Social Fund). The X-ray imaging work was supported by the Advanced Imaging of Materials (AIM) facility (EPSRC grant no. EP/M028267/1), the European Social Fund (ESF) through the European Union’s Convergence programme administered by the Welsh Government

Photon-mediated interactions between quantum emitters in a diamond nanocavity

Photon-mediated interactions between quantum systems are essential for realizing quantum networks and scalable quantum information processing. We demonstrate such interactions between pairs of silicon-vacancy (SiV) color centers coupled to a diamond nanophotonic cavity. When the optical transitions of the two color centers are tuned into resonance, the coupling to the common cavity mode results in a coherent interaction between them, leading to spectrally-resolved superradiant and subradiant states. We use the electronic spin degrees of freedom of the SiV centers to control these optically-mediated interactions. Such controlled interactions will be crucial in developing cavity-mediated quantum gates between spin qubits and for realizing scalable quantum network nodes

Adaptation of mammalian host-pathogen interactions in a changing arctic environment

Many arctic mammals are adapted to live year-round in extreme environments with low winter temperatures and great seasonal variations in key variables (e.g. sunlight, food, temperature, moisture). The interaction between hosts and pathogens in high northern latitudes is not very well understood with respect to intra-annual cycles (seasons). The annual cycles of interacting pathogen and host biology is regulated in part by highly synchronized temperature and photoperiod changes during seasonal transitions (e.g., freezeup and breakup). With a warming climate, only one of these key biological cues will undergo drastic changes, while the other will remain fixed. This uncoupling can theoretically have drastic consequences on host-pathogen interactions. These poorly understood cues together with a changing climate by itself will challenge host populations that are adapted to pathogens under the historic and current climate regime. We will review adaptations of both host and pathogens to the extreme conditions at high latitudes and explore some potential consequences of rapid changes in the Arctic

The restorative role of annexin A1 at the blood–brain barrier

Annexin A1 is a potent anti-inflammatory molecule that has been extensively studied in the peripheral immune system, but has not as yet been exploited as a therapeutic target/agent. In the last decade, we have undertaken the study of this molecule in the central nervous system (CNS), focusing particularly on the primary interface between the peripheral body and CNS: the blood–brain barrier. In this review, we provide an overview of the role of this molecule in the brain, with a particular emphasis on its functions in the endothelium of the blood–brain barrier, and the protective actions the molecule may exert in neuroinflammatory, neurovascular and metabolic disease. We focus on the possible new therapeutic avenues opened up by an increased understanding of the role of annexin A1 in the CNS vasculature, and its potential for repairing blood–brain barrier damage in disease and aging

Acquired Type III Secretion System Determines Environmental Fitness of Epidemic Vibrio parahaemolyticus in the Interaction with Bacterivorous Protists

Genome analyses of marine microbial communities have revealed the widespread occurrence of genomic islands (GIs), many of which encode for protein secretion machineries described in the context of bacteria-eukaryote interactions. Yet experimental support for the specific roles of such GIs in aquatic community interactions remains scarce. Here, we test for the contribution of type III secretion systems (T3SS) to the environmental fitness of epidemic Vibrio parahaemolyticus. Comparisons of V. parahaemolyticus wild types and T3SS-defective mutants demonstrate that the T3SS encoded on genome island VPaI-7 (T3SS-2) promotes survival of V. parahaemolyticus in the interaction with diverse protist taxa. Enhanced persistence was found to be due to T3SS-2 mediated cytotoxicity and facultative parasitism of V. parahaemolyticus on coexisting protists. Growth in the presence of bacterivorous protists and the T3SS-2 genotype showed a strong correlation across environmental and clinical isolates of V. parahaemolyticus. Short-term microcosm experiments provide evidence that protistan hosts facilitate the invasion of T3SS-2 positive V. parahaemolyticus into a coastal plankton community, and that water temperature and productivity further promote enhanced survival of T3SS-2 positive V. parahaemolyticus. This study is the first to describe the fitness advantage of GI-encoded functions in a microbial food web, which may provide a mechanistic explanation for the global spread and the seasonal dynamics of V. parahaemolyticus pathotypes, including the pandemic serotype cluster O3:K6, in aquatic environments

Transcriptomic Profiling of Virus-Host Cell Interactions following Chicken Anaemia Virus (CAV) Infection in an In Vivo Model.

Chicken Anaemia Virus (CAV) is an economically important virus that targets lymphoid and erythroblastoid progenitor cells leading to immunosuppression. This study aimed to investigate the interplay between viral infection and the host's immune response to better understand the pathways that lead to CAV-induced immunosuppression. To mimic vertical transmission of CAV in the absence of maternally-derived antibody, day-old chicks were infected and their responses measured at various time-points post-infection by qRT-PCR and gene expression microarrays. The kinetics of mRNA expression levels of signature cytokines of innate and adaptive immune responses were determined by qRT-PCR. The global gene expression profiles of mock-infected (control) and CAV-infected chickens at 14 dpi were also compared using a chicken immune-related 5K microarray. Although in the thymus there was evidence of induction of an innate immune response following CAV infection, this was limited in magnitude. There was little evidence of a Th1 adaptive immune response in any lymphoid tissue, as would normally be expected in response to viral infection. Most cytokines associated with Th1, Th2 or Treg subsets were down-regulated, except IL-2, IL-13, IL-10 and IFNγ, which were all up-regulated in thymus and bone marrow. From the microarray studies, genes that exhibited significant (greater than 1.5-fold, false discovery rate <0.05) changes in expression in thymus and bone marrow on CAV infection were mainly associated with T-cell receptor signalling, immune response, transcriptional regulation, intracellular signalling and regulation of apoptosis. Expression levels of a number of adaptor proteins, such as src-like adaptor protein (SLA), a negative regulator of T-cell receptor signalling and the transcription factor Special AT-rich Binding Protein 1 (SATB1), were significantly down-regulated by CAV infection, suggesting potential roles for these genes as regulators of viral infection or cell defence. These results extend our understanding of CAV-induced immunosuppression and suggest a global immune dysregulation following CAV infection

Current and Future Patterns of Global Marine Mammal Biodiversity

Quantifying the spatial distribution of taxa is an important prerequisite for the preservation of biodiversity, and can provide a baseline against which to measure the impacts of climate change. Here we analyse patterns of marine mammal species richness based on predictions of global distributional ranges for 115 species, including all extant pinnipeds and cetaceans. We used an environmental suitability model specifically designed to address the paucity of distributional data for many marine mammal species. We generated richness patterns by overlaying predicted distributions for all species; these were then validated against sightings data from dedicated long-term surveys in the Eastern Tropical Pacific, the Northeast Atlantic and the Southern Ocean. Model outputs correlated well with empirically observed patterns of biodiversity in all three survey regions. Marine mammal richness was predicted to be highest in temperate waters of both hemispheres with distinct hotspots around New Zealand, Japan, Baja California, the Galapagos Islands, the Southeast Pacific, and the Southern Ocean. We then applied our model to explore potential changes in biodiversity under future perturbations of environmental conditions. Forward projections of biodiversity using an intermediate Intergovernmental Panel for Climate Change (IPCC) temperature scenario predicted that projected ocean warming and changes in sea ice cover until 2050 may have moderate effects on the spatial patterns of marine mammal richness. Increases in cetacean richness were predicted above 40° latitude in both hemispheres, while decreases in both pinniped and cetacean richness were expected at lower latitudes. Our results show how species distribution models can be applied to explore broad patterns of marine biodiversity worldwide for taxa for which limited distributional data are available