Psychiatric Examination of Health Board Reports of Disability and Investigation of Differences Related to Regulation Amendment

The aim of the study is to investigate the sociodemographic characteristics, psychiatric diagnosis, disability rate and psychiatric dependency status of patients who applied for the health board report of disability and the differences emerged after the regulation change dated February 20, 2019. Data of 1315 individuals aged 18 and over who were evaluated between September 1, 2018 and August 31, 2019 were retrospectively analyzed, and the data of those patients evaluated before and after the regulation change were compared. 56.2% of the cases were male, 43.8% were female. The median age was 46. 32.8% of the patients were assigned a report due to mental illness. The rate of those diagnosed with a disability rate of 40 % and above was found to be 22.4 %. When the severe disability / full dependency assessments of patients with a disability rate of 50% and above were compared according to the old and new regulations. There was no significant difference between the groups. As a referee hospital, the initial assessment of 16.1% of the applicants as “not severely disabled” and 1% of the applicants as “severely disabled” was changed to “partially dependent”.In psychiatric cases, the level of functionality should be evaluated multidimensionally in relation to the course of the disease and various factors specific to the patient. It is thought that the intermediate rate “partially improves with treatment” and the definition of “partially dependent” brought to certain diseases by the new regulation can be a solution for the patients who lie in between

Structural Modelling and Structure-Function Analysis of <i>Zymomonas mobilis</i> Levansucrase

Levansucrases are bacterial enzymes which produce fructan polymers from sucrose via hydrolysis and transfructosylation activities. These polymers; levan and fructooligosaccharides are valuable for food and pharmaceutical industries. Levansucrases from Gram-positive bacteria such as Bacillus subtilis tend to produce levan, while those from Gram-negative bacteria preferentially produce fructooligosaccharides. Zymomonas mobilis is an efficient levansucrase producer and its extracellular levansucrase can produce both fructooligosaccharides and levan depending on the reaction parameters. In this study, the structure of Z. mobilis levansucrase was modeled in order to help to understand the structure-function relationship of the enzyme. Furthermore, amino acids previously reported to be important for levansucrase activity were mapped on the model. The structural model presents a five-bladed propeller with a deep, negatively charged central pocket, similar to other bacterial levansucrases. Mapping showed that amino acids which previously reported to affect fructan length are located on the periphery of the structure covering the active site central pocket. Thus it is showed that, for the first time, that hydrolysis and transfructosylation reactions are catalyzed on different parts of Z. mobilis levansucrase structure. The structural location of the critical amino acids will pave the way to identify other residues which control fructan length by site directed mutagenesis without altering the overall fold of the enzyme

Gıda kaynaklı protein ve biyoaktif peptit eldesi, saflaştırılması ve karakterizasyonunda kullanılan güncel yöntemler ve biyoinformatik yaklaşımlar

Günümüzde, beslenme alışkanlıkları ile insan sağlığı arasındaki ilişkinin ortaya konulması özellikle gıda kaynaklı biyoaktif bileşenleri hedef alan çalışmaların giderek artmasına sebep olmaktadır. Gıda kaynaklı peptitler ise sahip oldukları potansiyel biyoaktivite ile araştırmacılar için oldukça önemli bir alan olarak ortaya çıkmıştır. Biyoaktif peptitler, birçok sağlık etkisine sahip olan spesifik amino asit dizileridir ve sindirim enzimleri, proteolitik enzimler veya fermantasyon sonucu gerçekleşen protein hidrolizi ile ortaya çıkmaktadır. Protein hidrolizatları ve peptitlerin elde edilmesinde geleneksel hidroliz metotlarının yanı sıra birçok yeni teknoloji kullanılmakta, saflaştırılması aşamasında ise yeni membran ve kromatografi yöntemlerinden faydalanılmaktadır. Biyoaktivitesi tespit edilen peptitlerin amino asit dizileri ise çeşitli kütle spektrometresi yöntemleri ile belirlenmektedir. Bununla beraber, biyoaktif peptit tahminlemesi, tanımlanması, amino asit dizisi belirlenmesi ve karakterizasyonu amacıyla çok sayıda biyoinformatik araç geliştirilmiştir. Mevcut derleme, gıda kaynaklı protein ve hidrolizat eldesi, peptit ayrıştırılması, saflaştırılması ve yapısal karakterizasyonu için kullanılmakta olan deneysel ve biyoinformatik yöntemlerin geniş bir literatür özetini sunmayı hedeflemektedir

Some ethnoarchaeological notes on Alaybeyi Höyük in the light of present Alaybeyi Village

Ethnographic methods have a long history of use for the reconstruction of human behavior and cultural patterns at archaeological sites (e.g., Broderick, 2016; Sinopoli, 1991). However, although the record and interpretation of living culture have been practiced in academia for centuries, ethnoarchaeology as a sub-discipline of archaeology has emerged particularly during the 1960s. Since then, this disciplinary tool has been applied for examining and solving the archaeological problems including, site formation and depositional processes, documentation of technological advancements, settlement patterns, human-environment interactions, social systems and social strategies, as well as ideologies and belief systems. Aiming to explore some significant clues regarding to the unanswered questions about the subsistence strategies, rituals, animal burials, architecture, technologies, and human-environment interactions at Alaybeyi Höyük, an ethnographic field study was planned to be carried out particularly in Erzurum plain. In this case, the Alaybeyi village was found to be the most suitable study area since it lies at the closest location of Alaybeyi Höyük. Besides, people in the village still live on cattle pastoralism, small scale agriculture, as well as with an environmental condition probably very much similar to that experienced by the Chalcolithic and Iron Age people at Alaybeyi Höyük

The Healing Effects of Thymoquinone and Dexpanthenol in Sciatic Nerve Compression Injury in Rats

Introduction Functional healing of peripheral nerve injuries is still difficult. In this study, potential healing effects of thymoquinone and dexpanthenol in sciatic nerve compression injury (SCI) were investigated. Method: Twenty-four male Wistar albino rats which were applied compression injury to their sciatic nerves were randomly separated into four groups as following: “control” group contained six rats administered no pharmacological agent; “TMK” group consisted of six rats administered 10 mg/kg intraperitoneal thymoquinone once a day for one week; “DXP” group contained six rats administered 50 mg/kg intraperitoneal dexpanthenol once a day for one week; and “TMK–DXP” group consisted of six rats administered separately 10 mg/kg intraperitoneal thymoquinone and 50 mg/kg intraperitoneal dexpenthanol once a day for one week. Four weeks later from SCI, sciatic nerve function index (SFI) was applied before sacrifice of all rats, and then their crushed sciatic nerves were histopathologically examined, in terms of “Schwann cell count”, “axon and myelin degeneration”, “axon shape/size differences”, “fibrosis”, and “neovascularisation”. Results: “Schwann cell count” (p = 0.011), “axon and myelin degeneration” (p = 0.001), “axon shape/size differences” (p = 0.011), and “fibrosis and neovascularisation” (p = 0.026) scores were different between the control and TMK–DXP groups. SFI scores were different between the control and TMK groups (p = 0.002), between the control and TMK–DXP groups (p < 0.001), and between the DXP and TMK–DXP groups (p = 0.029). Conclusions: This study results revealed that these pharmacological agents used alone had no histopathological healing effect in rats with SCI, but thymoquinone could improve walking function. However, thymoquinone and dexpanthenol used together had a significant histopathological and functional healing effect

The Healing Effects of Thymoquinone and Dexpanthenol in Sciatic Nerve Compression Injury in Rats

BAKAR, BULENT/0000-0002-6236-7647WOS: 000484634600001PubMed: 31462122Introduction: Functional healing of peripheral nerve injuries is still difficult. In this study, potential healing effects of thymoquinone and dexpanthenol in sciatic nerve compression injury (SCI) were investigated. Method: Twenty-four male Wistar albino rats which were applied compression injury to their sciatic nerves were randomly separated into four groups as following: "control" group contained six rats administered no pharmacological agent; "TMK" group consisted of six rats administered 10 mg/kg intraperitoneal thymoquinone once a day for one week; "DXP" group contained six rats administered 50 mg/kg intraperitoneal dexpanthenol once a day for one week; and "TMK-DXP" group consisted of six rats administered separately 10 mg/kg intraperitoneal thymoquinone and 50 mg/kg intraperitoneal dexpenthanol once a day for one week. Four weeks later from SCI, sciatic nerve function index (SFI) was applied before sacrifice of all rats, and then their crushed sciatic nerves were histopathologically examined, in terms of "Schwann cell count", "axon and myelin degeneration", "axon shape/size differences", "fibrosis", and "neovascularisation". Results: "Schwann cell count" (p = 0.011), "axon and myelin degeneration" (p = 0.001), "axon shape/size differences" (p = 0.011), and "fibrosis and neovascularisation" (p = 0.026) scores were different between the control and TMK-DXP groups. SFI scores were different between the control and TMK groups (p = 0.002), between the control and TMK-DXP groups (p < 0.001), and between the DXP and TMK-DXP groups (p = 0.029). Conclusions: This study results revealed that these pharmacological agents used alone had no histopathological healing effect in rats with SCI, but thymoquinone could improve walking function. However, thymoquinone and dexpanthenol used together had a significant histopathological and functional healing effect.Scientific Research Projects Co-ordination Unit of Kirikkale UniversityKirikkale University [2014/98]This study was supported by the Scientific Research Projects Co-ordination Unit of Kirikkale University (Project No: 2014/98)