Exercise stress test and comparison of ST change with cardiac nucleotide catabolite production in patients with coronary artery disease

Background: Uridine (Ur) and hypoxanthine (Hx) are the major end products of ischemic nucleotide breakdown in the human heart. Hypoxanthine is further metabolized to uric acid (UA). The aim of the study was the evaluation of whether changes in nucleotide concentrations during exercise correlate with electrocardiography (ECG) changes, and the severity of coronary artery disease (CAD). Methods: Twenty-nine males with CAD and 11 controls without CAD (mean age 56.1 vs. 51.45) were subjected to treadmill exercise. The test was considered positive if ECG showed more then 1 mm ST segment depression. Venous blood samples taken before and 10 minut after the exercise were analysed by high performance liquid chromatography. Results: Twenty-two out of 29 patients with CAD and 6 of 11 in the control group had abnormal exercise stress tests according to ECG criteria only. Mean &#8710;Ur was positive in the CAD group and negative in the control group (0.45 SEM &#177; 0.09 &#181;M/L vs. -0.43 SEM &#177; 0.21 &#181;M/L, p < 0.0001). &#8710;UA was positive in the CAD group (15.31 SEM &#177; 5.52 &#181;M/L) and negative in the control group (15.31 SEM &#177; 5.52 &#181;M/L vs. -48.18 SEM &#177; 13,8 &#181;M/L, p < 0.00001); Hx increased in both groups, and the change was not significantly different. Correlations of CAD-index with ST depression, &#8710;Ur and &#8710;UA, were: r = 0.43 (p < 0.005), r = 0.62 (p < 0.001), and r = 0.39 (p < 0.01), respectively. Sensitivity of any increase of uridine was superior to 1.5 mm ST depression during exercise. Conclusions: Blood Ur and UA concentration changes during exercise correlate with severity of CAD. We observed slightly greater accuracy of uridine change in comparison to ST changes, thus being a possible new tool in diagnosis of CAD. (Cardiol J 2007; 14: 573-579)

Potential range of impact of an ecological trap network: the case of timber stacks and the Rosalia longicorn

Although the negative impact of timber stacks on populations of saproxylic beetles is a well-known phenomenon, there is relatively little data concerning the scale of this impact and its spatial aspect. Beech timber stored in the vicinity of the forest can act as an ecological trap for the Rosalia longicorn (Rosalia alpina), so in this study we have attempted to determine the spatial range of the impact of a network of timber stacks. Timber stacks in the species’ range in the study area were listed and monitored during the adult emergence period in 2014–2016. Based on published data relating to the species’ dispersal capabilities, buffers of four radii (500, 1000, 1600, 3000 m) were delineated around the stacks and the calculated ranges of potential impact. The results show that the percentage of currently known localities of the Rosalia longicorn impacted by stacks varies from 19.7 to 81.6%, depending on the assumed impact radius. The percentage of forest influenced by timber stacks was 77% for the largest-radius buffer. The overall impact of the ecological trap network is accelerated by fragmentation of the impact-free area. It was also found that forests situated close to the timber stacks where the Rosalia longicorn was recorded were older and more homogeneous in age and species composition than those around stacks where the species was absent. Such results suggest that timber stacks act as an ecological trap in the source area of the local population

Cardiopoietic cell therapy for advanced ischemic heart failure: results at 39 weeks of the prospective, randomized, double blind, sham-controlled CHART-1 clinical trial

Cardiopoietic cells, produced through cardiogenic conditioning of patients' mesenchymal stem cells, have shown preliminary efficacy. The Congestive Heart Failure Cardiopoietic Regenerative Therapy (CHART-1) trial aimed to validate cardiopoiesis-based biotherapy in a larger heart failure cohort

Synergism of manufacturing technologies and durability of areological systems of tools

Podano informacje o kompozycji technologii wytwarzania i o wartościowaniu kompozycji tych technologii - przez autorskie wprowadzenie pojęcia współczynnika oddziaływania i jako pochodnego - współczynnika synergizmu. Omówiono efekt kompozycji technologii - synergizm żądanych właściwości oraz podano zestawienie liczbowe współczynnika synergizmu trwałości eksploatacyjnej narzędzi jako funkcję technologii wytwarzania dla systemu areologicznego bezpowłokowego (rdzeniowego) oraz powłokowego. Zasygnalizowano dalsze możliwości wykorzystania pojęcia współczynnika synergizmu.The information on composition of manufacturing technology and on quantification of composition of this technology by authors introduction of idea of coefficient of interaction and - as derivative - the coefficient of synergism was done. The effect of composition of technology (the synergism of demand proprieties) was discussed and number-set of coefficient of synergism of durability exploitation of tools - as function of manufacturing technology for the areological coating system and core system was described. The farther possibilities of utilization of idea of synergism coefficient were presented

The role of absorption radiation in the process of laser heating

Omówiono oddziaływanie promieniowania świetlnego z obrabianym materiałem i rodzaje współczynnika pochłaniania (całkowity, monochromatyczny, półprzestrzenny i kierunkowy). Podano ogólną zależność pochłanialności od 9 zmiennych. Przedstawiono wpływ chropowatości i stopnia skorodowania powierzchni metalowych na pochłanialność promieniowania. Omówiono emisję i absorpcję promieniowania laserowego, różnicę między mocą (i gęstością mocy) padającą a pochłoniętą. Podano sposoby zwiększania współczynnika absorpcji.The interaction of light radiation with treated material and kinds of coefficient absorption (total, monochromatic, semispherical and directional) was presented. The general absorptivity from 9 variables was done. The influence of surface roughness and corrosion stage on radiation absorptivity, was described. The emission and absorption of laser radiation and the difference between the incidence and absorbed radiation power (and radiation density power) was done. The methods of coefficient absorption increasing were presented

Kinds laser texturing in tribology

W artykule przedstawiono ideę teksturowania laserowego, autorski podział oraz schematy ideowe różnych tekstur. Przedstawiono wybrane przykłady technologiczne zastosowania teksturowania laserowego w areologii na przykładzie żeliwa szarego EN-GJL300 i stopu aluminium ENAW-2618A (PA31). Przedstawiono również kierunki rozwoju teksturowania w areologii i tribologii.The idea laser texturing was introduced in the article, his the author's mislaid in the aerology and the ideological patern of various textures. Chosen examples were introduced technological uses laser texturing in the engineering of surface on the example of grey cast iron EN-GJL300 and melt of aluminum ENAW-2618A (PA31). The directions of the development texturing were also introduced in the aerology and tribology