THE ASSOCIATION BETWEEN ALTMETRIC, PLUMX METRICS AND CITATION COUNT OF PUBLICATIONS: A CROSS-SECTIONAL STUDY AMONG TOP CHILD AND ADOLESCENT PSYCHIATRY JOURNALS

Background: Altmetric Attention Score (AAS) and PlumX Metrics are becoming important to evaluate the impact of the publication in addition to classical scientific rating method such as citation count and impact factor. These metrics collect data about publications’ tweet count, Facebook interaction count and other social interactions. In this study, it is aimed to examine the association between AAS, PlumX Metrics and citation count of top child and adolescent psychiatry. Methods: We identified the five journals and retrospectively analysed the publications published in 2019. All the original research articles, met analysis, and reviews were analysed. The articles were divided into two groups as original articles/research articles and meta-analysis/systematic review. We have hypothesized that there could be a positive correlation between AAS and PlumX Metrics data and citation count among these journals and there could be a difference between AAS, PlumX scores and citation count between original articles/research articles and meta-analysis/systematic review as their reading potential is different. Results: We have found a significant positive correlation between citation count, AAS and PlumX Metrics. This association continued after controlling the journal impact factor. In linear regression analysis, type of publication, total count of tweets, and Mendeley reads predicted the citation count. Conclusion: In addition to the classical methods measuring the quality of the articles such as the total citation count and impact factor, the importance of AAS and PlumX Metrics has been increasing. It is important to share scientific publications on these platforms in order to increase the impact of the articles

The relationship between major depressive disorder and leptin receptor polymorphism in children and adolescents

Bu çalışma majör depresif bozukluk (MDB) tanısı koyulan ergen yaş grubu hastalarında leptin reseptör polimorfizminin araştırılması amacı ile tasarlanmıştır. MDB tanısı koyulan ergen hastalar leptin reseptör polimorfizmi açısından cinsiyet ve yaş olarak anlamlı fark olmayan sağlıklı kontroller ile karşılaştırılmış ve hasta grubunda kontrol grubuna göre polimorfizm tespit edilme sıklığı açısından anlamlı bir farklılık tespit edileceği hipotezi test edilmiştir. Yöntem: Çalışma, Necmettin Erbakan Üniversitesi Çocuk ve Ergen Psikiyatrisi Anabilim Dalıayaktan tedavi ünitesinde yapılmıştır. DSM 5 tanı ölçütlerine göre birincil tanısı major depresif bozukluk olan 12-18 yaş arası98 hasta çalışmaya dahil edilmiştir.Kontrol grubunu Necmettin Erbakan Üniversitesi Çocuk ve Ergen RuhSağlığı ve Hastalıkları AD ayaktan tedavi ünitesine başvuran herhangi bir psikiyatrik bozukluğu olmayan ergenler ve ailelerioluşturmuştur. İçleme ölçütlerine uygun olanlara çalışmanın amacı ve niteliği anlatılmış ve aydınlatılmış onamları alınmış, takiben çalışmada kulanılacak ölçekler doldurtulmuştur. Araştırmacı tarafından katılımcının boy ve tartısı, bel ve kalça çevresi ölçülmüştür. Sonrasında hastadan EDTA'lı tüpe 5 cc kan alınmış ve analize kadar -20 C'de saklanmıştır. Kandan DNA izolasyonu sonrasında uygun primerler kullanılarak LEPR gen bölgesi çoğaltılmış ve PZR-RFLP yöntemi ile belirlenen SNP'ler incelenmiştir. Bulgular:Çalışmamızda rs1805134, rs1805096, rs1171276, rs9436746, rs1137101 tek nükleotid polimorfizmlerinin hasta grubunda anlamlı bir farklılık bulunamamıştır. Yalnızca rs1805096 tek nükleotid polimorfizmi açısından anlamlılığa yakın bir farklılık tespit edilmiştir. (p=0,088)Araştırılan SNP bölgelerinin allel durumları numerik veri olarak kodlandıktan sonra depresyon skorları toplam puanları ile yapılan koreasyon analizinde hiçbir bölge ile depresyon skorları arasında anlamlı korelasyon tespit edilememiştir. Sonuç:Leptin reseptör genindeki araştırılanSNP'ler ile depresif belirtiler arasında bir ilişki tespit edilememiş olsa da rs1805096 tek nükleotid polimorfizmi görülme sıklığı açısından hasta ve kontrol grubu arasında anlamlılığa yakın bir farklılık tespit edilmiştir. Prospektif desende ve daha geniş örneklemi inceleyen araştırmalara ihtiyaç bulunmaktadır. Anahtar Kelimeler: depresyon, çocuk, ergen, leptin reseptörü, obezite Çalışmamız için gerekli olan maddi destek Necmettin Erbakan Üniversitesi Bilimsel Araştırma Projeleri Komisyonu tarafından 161518007 proje numarası ile sağlanmıştır.This study was designed with the aim of investigating leptin receptor polymorphism in adolescents diagnosed with major depressive disorder (MDD). Adolescents with MDD diagnosed were compared with healthy controls with no significant difference in terms of sex and age in terms of leptin receptor polymorphism and the hypothesis that a significant difference in the frequency of polymorphism detection compared to the control group in the patient group was tested. Method: The study was carried out at the outpatient unit of Necmettin Erbakan University Child and Adolescent Psychiatry Department. According to DSM 5 diagnostic criteria, 98 patients aged 12-18 years with primary diagnosis of major depressive disorder were included in the study. The control group consisted of adolescents and their parents, did not have any psychiatric disorder, applied to the Necmettin Erbakan University Child and Adolescent Psychiatry Departmentoutpatient unit. Study is explained and clarified with whose are suitable for the inclusion criteria and then the scales to be used for work are filled. The participant's height and weight, waist and hip circumference were measured by the researcher. The patient then received 5 cc of blood from the patient's EDTA tube and stored at -20 ° C until analysis. After the DNA isolation, the LEPR gene region was amplified using appropriate primers and the SNPs determined by the PCR-RFLP method were examined. Results: No significant correlation was found between depression scores and SNP regions in correlation analysis In our study, single nucleotide polymorphisms of rs1805134, rs1805096, rs1171276, rs9436746, rs1137101 were not found to be significantly more common in the patient group. Only a meaningful difference was found in terms of single nucleotide polymorphism of rs1805096. (P = 0.088) Conclusion:Although no association was found between the SNPs investigated in the leptin receptor gene and depressive symptoms, a significant difference was found between the patient and the control group in terms of the frequency of rs1805096 single nucleotide polymorphism. There is a need for prospective design and studies that examine in larger population. Keywords: depression, child, adolescent, leptin receptor, obesity The financial support required for our work is provided by Necmettin Erbakan University Scientific Research Projects Commission with project number 161518007

The association between parents' problematic smartphone use and children's speech delay

*Kara, Halil ( Aksaray, Yazar )Objective: Children's use of television is an important environmental risk factor associated with speech delay. Although the relationship between television use and speech delay has been examined, there is no study in the literature investigating the relationship between parent's smartphone use and speech delay. In this study, we aimed to investigate the relationship between speech delay and problematic smartphone use and to test the hypothesis that the rate of problematic smartphone use is higher in the parents of children with delayed speech compared to those parents of children with healthy development. Methods: 20 children with delayed speech and their parents (patient group) and 20 children with normal speech development and their parents (control group) were included the study. The development of children evaluated with Ankara Developmental Screening Inventory. The problematic smartphone use measured by Problematic Mobile Phone Usage Scale. Results: Problematic Mobile Phone Usage Scale score was significantly higher in parents of children with speech delay. This difference continues after controlling confounding effect of parent's age, education, and income level. Conclusion: In this study, problematic smartphone usage was found to be more frequent in families of children with speech delay. According to our knowledge this is the first study which investigates the association with speech delay and parent's use of smartphone. While evaluating children with speech delay in clinical practice, it is essential that the smartphone usage of the parents is taken into consideration further prospective, follow-up studies can be conducted on this topic

Serum zonulin levels are higher among children with autism spectrum disorders and correlated with social impairment

Zonulin is a protein that affects the integrity of intercellular connections in the intestines. It has been emphasized that autoimmune diseases as well as neurodevelopmental disorders, for example autism spectrum disorder (ASD), may occur through alterations in intestinal permeability and blood-brain barrier. We aimed to investigate the gastrointestinal permeability of individuals with ASD by determining serum zonulin levels and their relationship to symptom severity. Methods: Twenty-five ASD patients and 19 controls were included. Serum zonulin levels were measured by enzyme-linked immunosorbent assay kits. Clinical severity was assessed by the Childhood Autism Rating Scale (CARS), and social skills of the control group were evaluated by the Conners’ Parents and Teacher’s Rating Scales-Revised/Long Forms (CPRS-CTRS). Results: Mean zonulin levels were significantly higher in the ASD group and positively correlated with CARS scores. After regression analysis, serum zonulin levels predicted CARS total scores. We could not find any significant correlation between zonulin levels and CPRS-CTRS sociability subscale scores in the control group. Conclusion: The positive correlation between serum zonulin levels and ASD severity may require precaution for impaired intestinal permeability in clinical practice, especially for the cases in which sociability is severely impaired. However, it is too early to state that intestinal permeability has a role in the etiology of ASD. Further studies involving specific autism subgroups, and samples with certain dietary differences are needed