Extrapolations of Lattice Meson Form Factors

We use chiral perturbation theory to study the extrapolations necessary to make physical predictions from lattice QCD data for the electromagnetic form factors of pseudoscalar mesons. We focus on the quark mass, momentum, lattice spacing, and volume dependence and apply our results to simulations employing mixed actions of Ginsparg-Wilson valence quarks and staggered sea quarks. To determine charge radii at quark masses on the lattices currently used, we find that all extrapolations except the one to infinite volume make significant contributions to the systematic error.Comment: 14pp, discussion and Ref. added for disconnected diagram

An HI absorption distance to the black hole candidate X-ray binary MAXI J1535-571

With the Australian Square Kilometre Array Pathfinder (ASKAP) we monitored the black hole candidate X-ray binary MAXI J1535--571 over seven epochs from 21 September to 2 October 2017. Using ASKAP observations, we studied the HI absorption spectrum from gas clouds along the line-of-sight and thereby constrained the distance to the source. The maximum negative radial velocities measured from the HI absorption spectra for MAXI J1535--571 and an extragalactic source in the same field of view are $-69\pm4$ km s$^{-1}$ and $-89\pm4$ km s$^{-1}$, respectively. This rules out the far kinematic distance ($9.3^{+0.5}_{-0.6}$ kpc), giving a most likely distance of $4.1^{+0.6}_{-0.5}$ kpc, with a strong upper limit of the tangent point at $6.7^{+0.1}_{-0.2}$ kpc. At our preferred distance, the peak unabsorbed luminosity of MAXI J1535--571 was $>78$ per cent of the Eddington luminosity, and shows that the soft-to-hard spectral state transition occurred at the very low luminosity of 1.2 -- 3.4 $\times$ 10$^{-5}$ times the Eddington luminosity. Finally, this study highlights the capabilities of new wide-field radio telescopes to probe Galactic transient outbursts, by allowing us to observe both a target source and a background comparison source in a single telescope pointing.Comment: Revised after favorable referee report from MNRAS Letter

A Giant Outburst at Millimeter Wavelengths in the Orion Nebula

BIMA observations of the Orion nebula discovered a giant flare from a young star previously undetected at millimeter wavelengths. The star briefly became the brightest compact object in the nebula at 86 GHz. Its flux density increased by more than a factor of 5 on a timescale of hours, to a peak of 160 mJy. This is one of the most luminous stellar radio flares ever observed. Remarkably, the Chandra X-ray observatory was in the midst of a deep integration of the Orion nebula at the time of the BIMA discovery; the source's X-ray flux increased by a factor of 10 approximately 2 days before the radio detection. Follow-up radio observations with the VLA and BIMA showed that the source decayed on a timescale of days, then flared again several times over the next 70 days, although never as brightly as during the discovery. Circular polarization was detected at 15, 22, and 43 GHz, indicating that the emission mechanism was cyclotron. VLBA observations 9 days after the initial flare yield a brightness temperature Tb > 5 x 10^7 K at 15 GHz. Infrared spectroscopy indicates the source is a K5V star with faint Br gamma emission, suggesting that it is a weak-line T Tauri object. Zeeman splitting measurements in the infrared spectrum find B ~ 2.6 +/- 1.0 kG. The flare is an extreme example of magnetic activity associated with a young stellar object. These data suggest that short observations obtained with ALMA will uncover hundreds of flaring young stellar objects in the Orion region.Comment: 29 pages, 7 figures, accepted for publication in Ap

Molecular profiling of multiplexed gene markers to assess viability of ex vivo human colon explant cultures

© Janice E. Drew et al. 2015; Published by Mary Ann Liebert, Inc. This Open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. Acknowledgments The authors would like to thank the patients who kindly donated tissue samples, Sally Chalmers of the Tayside Tissue Bank for her help with collecting of the tissue donor samples, Emma Moss for advice on human colon dissection and explant culture, and Claus Dieter Mayer, Biomathematics and Statistics Scotland, for advice on statistical analysis. This work was supported by the Scottish Government (GT403), Scottish Universities Life Science Alliance, and TENOVUS Scotland.Peer reviewedPublisher PD

Absence of Embigin accelerates hearing loss and causes sub-viability, brain and heart defects in C57BL/6N mice due to interaction with Cdh23ᵃʰˡ

Mouse studies continue to help elaborate upon the genetic landscape of mammalian disease and the underlying molecular mechanisms. Here, we have investigated an Embigintm1b allele maintained on a standard C57BL/6N background and on a co-isogenic C57BL/6N background in which the Cdh23ahl allele has been “repaired.” The hypomorphic Cdh23ahl allele is present in several commonly used inbred mouse strains, predisposing them to progressive hearing loss, starting in high-frequency regions. Absence of the neural cell adhesion molecule Embigin on the standard C57BL/6N background leads to accelerated hearing loss and causes sub-viability, brain and cardiac defects. Contrastingly, Embigintm1b/tm1b mice maintained on the co-isogenic “repaired” C57BL/6N background exhibit normal hearing and viability. Thus Embigin genetically interacts with Cdh23. Importantly, our study is the first to demonstrate an effect of the common Cdh23ahl allele outside of the auditory system, which has important ramifications for genetic studies involving inbred strains carrying this allele

A kinetic and theoretical study of the borate catalysed reactions of hydrogen peroxide: the role of dioxaborirane as the catalytic intermediate for a wide range of substrates

Our recent work has provided new insights into the equilibria and species that exist in aqueous solution at different pHs for the boric acid – hydrogen peroxide system, and the role of these species in oxidation reactions. Most recently, (M. C. Durrant, D. M. Davies and M. E. Deary, Org. Biomol. Chem., 2011, 9,7249–7254), we have produced strong theoretical and experimental evidence for the existence of a previously unreported monocyclic three membered peroxide species, dioxaborirane, that is the likely catalytic species in borate mediated electrophilic reactions of hydrogen peroxide in alkaline solution. In the present paper, we extend our study of the borate–peroxide system to look at a wide range of substrates that include substituted dimethyl anilines, methyl-p-tolyl sulfoxide, halides, hydrogen sulfide anion, thiosulfate ,thiocyanate, and hydrazine. The unusual selectivity–reactivity pattern of borate catalysed reactions compared with hydrogen peroxide and inorganic or organic peracids previously observed for theorganic sulfides (D. M. Davies, M. E. Deary, K. Quill and R. A. Smith, Chem.–Eur. J., 2005, 11, 3552–3558) is also seen with substituted dimethyl aniline nucleophiles. This provides evidence that the pattern is not due to any latent electrophilic tendency of the organic sulfides and further supports dioxaborirane being the likely reactive intermediate, thus broadening the applicability of this catalytic system. Moreover, density functional theory calculations on our proposed mechanism involving dioxaborirane are consistent with the experimental results for these substrates. Results obtained at high concentrations of both borate and hydrogen peroxide require the inclusion the diperoxodiborate dianion in the kinetic analysis .A scheme detailing our current understanding of the borate–peroxide system is presented

The UTMOST: A hybrid digital signal processor transforms the MOST

The Molonglo Observatory Synthesis Telescope (MOST) is an 18,000 square meter radio telescope situated some 40 km from the city of Canberra, Australia. Its operating band (820-850 MHz) is now partly allocated to mobile phone communications, making radio astronomy challenging. We describe how the deployment of new digital receivers (RX boxes), Field Programmable Gate Array (FPGA) based filterbanks and server-class computers equipped with 43 GPUs (Graphics Processing Units) has transformed MOST into a versatile new instrument (the UTMOST) for studying the dynamic radio sky on millisecond timescales, ideal for work on pulsars and Fast Radio Bursts (FRBs). The filterbanks, servers and their high-speed, low-latency network form part of a hybrid solution to the observatory's signal processing requirements. The emphasis on software and commodity off-the-shelf hardware has enabled rapid deployment through the re-use of proven 'software backends' for its signal processing. The new receivers have ten times the bandwidth of the original MOST and double the sampling of the line feed, which doubles the field of view. The UTMOST can simultaneously excise interference, make maps, coherently dedisperse pulsars, and perform real-time searches of coherent fan beams for dispersed single pulses. Although system performance is still sub-optimal, a pulsar timing and FRB search programme has commenced and the first UTMOST maps have been made. The telescope operates as a robotic facility, deciding how to efficiently target pulsars and how long to stay on source, via feedback from real-time pulsar folding. The regular timing of over 300 pulsars has resulted in the discovery of 7 pulsar glitches and 3 FRBs. The UTMOST demonstrates that if sufficient signal processing can be applied to the voltage streams it is possible to perform innovative radio science in hostile radio frequency environments.Comment: 12 pages, 6 figure

Views and experiences of opioid access amongst palliative care providers and public representatives in a low-resource setting: A qualitative interview study

AbstractOpioids (e.g. morphine) are affordable, effective interventions for cancer-related pain. However, equity of access to this key medication remains a global challenge, particularly in low- and middle-income countries. We aimed to explore views of palliative care providers and public-representatives about opioid analgesia access in two States in India. We conducted a qualitative study using semi-structured interviews. Transcribed audio-recordings were subjected to thematic analysis using a Framework Approach. Palliative care providers and public-representatives were purposively sampled from services reporting consistent opioid availability and prescribing (≥4kg per annum) from Karnataka and Kerala. Twenty participants (doctors (10), nurses (4), pharmacists (2), service managers (2) and public-representatives (2) were interviewed. Three themes were identified: 1) Attitudes and awareness: opioid treatments are perceived as end-of-life (last days/weeks) interventions; fears of addiction and misunderstanding of pain management goals limit access. 2) Expected and unexpected inequities: patients/carers from lower socioeconomic strata accept doctor recommendations if opioids are affordable, more educated patients/families have reservations about opioids, delay access and perceive expensive medicines as better. Non-palliative care specialist doctors have negative entrenched views and require specialist training. 3) Experiential learning–positive experiences can positively alter attitudes (e.g., participants in Kerala report improved attitudes, awareness and understanding influenced by exposure and community awareness, but experience can also reinforce perceptions as end-of-life care. Entrenched negative views are reinforced by poor experiences while positive experiences improve attitudes. To promote access, opioid prescribing must be needs-based rather than prognosis-based. Addressing the lack of training for non-palliative care workforce would help overcome a major barrier