Physicochemical quality evaluation of acetylsalicylic acid tablets distributed by a basic pharmacy

The present paper aims to investigate the physicochemical quality of pharmaceutical drugs acquired and distributed by the Basic Pharmacy of the city of Cascavel-Paraná State. During the period between June 2004 and March 2006, samples of eight batches of acetylsalicylic acid 100 mg produced by two laboratories were analyzed. Following the techniques and specifications established by official compendiums, physicochemical tests of disintegration, dissolution, hardness, friability, uniformity of mass, content and limit of free acetylsalicylic acid were carried out. All the analyzed products presented quality deviations. All the six batches produced by one of the laboratories failed in the punctual dissolution test. The dissolution profile test confirmed such results, showing that these six batches cannot be considered equivalent to the branded drug.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Influence of chondroitin sulfate in the formation of ethylcellulose isolated films

Filmes isolados do sulfato de condroitina (SC) associado à Etilcelulose (EC) obtidos pelo processo de evaporação "casting process" em placa de Teflon®, foram investigados para determinação Ii % em fluidos de simulação gástrica ou intestinal, assim como, permeabilidade ao vapor d'água. O SC foi adicionado as dispersões aquosas de EC nas concentrações (4% m/v) 90:10 e 80:20. Os valores das espessuras dos filmes foram: EC100:0SC - 0,90(±0,007); EC90:10SC - 0,102(±0,005); EC80:20SC - 0,125(±0,002). Os filmes na composição 90:10 com SC demonstraram propriedades de hidratação e permeabilidade com potencial perspectiva de aplicação no desenvolvimento de novos sistemas reservatórios para a liberação modificada de fármacos.Isolated films from chondroitine sulfate (CS) coupled to Ethylcellulose (EC), obtained by evaporation casting process in Teflon® plate, have been analyzed to determine Ii% gastric or intestine simulation fluids and their permeability to water vapour. CS was added to EC water dispersions in concentrations (4% m/v) 90:10 and 80:20. Film thickness rates were EC100:0SC - 0.90 (±0.007); EC90:10SC - 0.102(±0.005); EC80:20SC - 0.125(±0.002). Films comprising 90:10 (EC:CS) concentration presented hydration and permeability with the perspective potential of their application to the development of new reservoir systems for a drug release.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Synthetic polyelectrolytes in the clarification of stevia aqueous extract Aplicação de polieletrólitos sintéticos na clarificação do extrato aquoso de estévia

The extract of stevia leaves is usually dark which demands a clarification in order to be accepted by sweetener consumers. One of the using techniques is the decantation, which requires the use of effective products for best results. In the market, flocculant products are available, such as: NOVUSTM CE2666 (cationic) and BETZDEARBORNTMF11 (anionic). When these products are used at a certain level of concentration, satisfactory results of decantation and consequent clarification are provided. The aim of this paper was to compare the performance of the best polymers by removal percentage (color and turbidity) and by the decantation speed. A Jar Test device was used and the concentration of coagulant (aluminum sulfate) and of polyelectrolytes were varied, as well as pH at 8,0, 9,0 and 10,0. Calcium oxide was applied in this phase. The best condition was obtained when the anionic polyelectrolyte was used, reaching a turbidity removal of 97%.O extrato das folhas de estévia são normalmente de cor escura, exigindo uma clarificação para que se apresente com aspecto aceitável frente aos consumidores de adoçantes. Dentre as técnicas utilizadas figura a decantação, a qual necessita, porém, de bons produtos para sua eficácia. No mercado estão disponíveis produtos floculantes, tais como: NOVUSTMCE2666 (catiônico) e BETZDEARBORNTMF11 (aniônico), que utilizados em determinadas concentrações proporcionam resultados satisfatórios de decantação e conseqüente clarificação. O objetivo deste trabalho foi comparar através da percentagem de despigmentação (cor e turbidez) e velocidade de decantação, qual o melhor polímero. Utilizando-se um aparelho de Jar Test, fez-se testes variando-se a concentração do coagulante (sulfato de alumínio e dos polieletrólitos e variou-se também o pH em 8,0, 9,0 e 10,0 aplicando-se óxido de cálcio. A melhor condição foi conseguida utilizando o polieletrólito aniônico onde atingiu-se 97% para a percentagem de despigmentação (turbidez)

ANÁLISES FÍSICO-QUÍMICAS DE BIOFILMES DE SULFATO DE CONDROITOINA MODIFICADO

Numerous investigations are dedicated to the research and development of new polymer materials destined for innovation in pharmaceutical forms. The application of these technological resources has allowed the commercialization of new therapeutic systems for modified drug release. This investigation aimed to evaluate the association of modified chondroitin sulfate with an insoluble polymer, Eudragit® RS 30 D, widely available in the pharmaceutical market. Isolated films were prepared by the evaporation process using a Teflon® plate. The aqueous dispersions (4% m/v) of synthetic polymer received the addition of modified chondroitin sulfate at different ratios. The interactions of the polymer chains in the blends were physicochemically characterized by means of Fourier transform infrared spectroscopy, thermal analyses, differential scanning calorimetry, thermogravimetry and scanning electron microscopy combined with hydration and assays in alkaline pH. The results showed appropriate properties of the coating materials for solid oral forms intended for drug deliver in specific environments

Eudragit ® FS 30 D polymeric films containing chondroitin sulfate as candidates for use in coating seeking modified delivery of drugs

ABSTRACT Polymeric films associating different concentrations of Eudragit(r) FS 30 D (EFS) and chondroitin sulfate (CS) were produced by casting for the development of a new target-specific site material. Formed films kept a final polymer mass of 4% (w/v) in the following proportions: EFS 100:00 CS (control), EFS 95:05 CS, EFS 90:10 CS and EFS 80:20 CS. They were analyzed for physical and chemical characteristics using Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and Raman spectroscopy. Furthermore, they were characterized by their water vapor permeability and degree of hydration at different conditions simulating the gastrointestinal tract. No chemical interactions were observed between CS and EFS, suggesting only a physical interaction between them in the different combinations tested. The results suggest that EFS and CS, when combined, may form films that are candidates for coating processes seeking a modified drug delivery, especially due to the synergism between pH dependency and specific biodegradability properties by the colonic microbiota. EFS 90:10 CS proved to be the most suitable for this purpose considering hydration and permeability characteristics of different associations analyzed