1,4-Diferrocenylbutane-1,4-dione

In the crystal structure of the title compound, [Fe2(C5H5)2(C14H12O2)], each carbonyl group is coplanar with the adjacent cyclo­penta­dienyl ring, thus maximizing the π-orbital overlap and electronic inter­actions between the groups. In the crystal structure, there are inter- and intra­molecular C—H⋯O contacts

Prevalence of Hypertension among High School Students in a Middle Anatolian Province of Turkey

Hypertension may lead to irreversible damages in vital organs, such as heart, brain, and kidney, and may cause death in children if treatments are not given despite early diagnosis. This cross-sectional epidemiological study was conducted during 1 January–31 March 2004 to investigate the prevalence of hypertension among high school students. The study cohort included 1,041 students of six high schools, who were selected from among 14,789 students of 26 high schools in Sivas province of Turkey, using the cluster-sampling method. A questionnaire was used for collecting information from students on age, gender, smoking, and whether they or their families have any diseases. Blood pressure, height, and weight of the participitants were determined by the research group. Students whose repeated systolic or diastolic blood pressures were higher than the 95th percentile were considered to be hypertensive patients. Hypertension was prevalent among 4.4% (n=45) of the students. There was a significant correlation between prevalence of hypertension and body mass index. No significant correlation was found between prevalence of hypertension and other variables, such as smoking, age, gender, and family history of diabetes. The results suggest that hypertension is an important public-health problem among high school students. The results also showed that the body mass index was an important parameter in hypertension in such a study group. Researchers should consider overweight a causative risk factor for development of hypertension in early-onset groups

Prevalence of Hypertension among High School Students in a Middle Anatolian Province of Turkey

Hypertension may lead to irreversible damages in vital organs, such as heart, brain, and kidney, and may cause death in children if treatments are not given despite early diagnosis. This cross-sectional epidemiological study was conducted during 1 January-31 March 2004 to investigate the prevalence of hypertension among high school students. The study cohort included 1,041 students of six high schools, who were selected from among 14,789 students of 26 high schools in Sivas province of Turkey, using the cluster-sampling method. A questionnaire was used for collecting information from students on age, gender, smoking, and whether they or their families have any diseases. Blood pressure, height, and weight of the participitants were determined by the research group. Students whose repeated systolic or diastolic blood pressures were higher than the 95th percentile were considered to be hypertensive patients. Hypertension was prevalent among 4.4% (n=45) of the students. There was a significant correlation between prevalence of hypertension and body mass index. No significant correlation was found between prevalence of hypertension and other variables, such as smoking, age, gender, and family history of diabetes. The results suggest that hypertension is an important public-health problem among high school students. The results also showed that the body mass index was an important parameter in hypertension in such a study group. Researchers should consider overweight a causative risk factor for development of hypertension in early-onset groups

Changes in Serum Natriuretic Peptide Levels after Percutaneous Closure of Small to Moderate Ventricular Septal Defects

Background. B-type natriuretic peptide has been shown to be a very sensitive and specific marker of heart failure. In this study, we aimed to investigate the effect of percutaneous closure of ventricular septal defects with Amplatzer septal occluders on brain natriuretic peptide levels. Methods. Between 2008 and 2011, 23 patients underwent successfully percutaneous ventricular septal defect closure in 4 cardiology centers. Brain natriuretic peptide levels were measured in nine patients (4 male, mean ages were 25.3 ± 14.3) who underwent percutaneous closure with Amplatzer occluders for membranous or muscular ventricular septal defects were enrolled in the study. Brain natriuretic peptide levels were measured one day before and one month after the closure. Patients were evaluated clinically and by echocardiography one month after the procedure. Results. Percutaneous closures of ventricular septal defects were successfully performed in all patients. There was not any significant adverse event in patients group during followup. Decrease in brain natriuretic peptide levels after closure were statistically significant (97.3 ± 78.6 versus 26.8 ± 15.6, P = 0.013). Conclusion. Brain Natriuretic Peptide levels are elevated in patients with ventricular septal defects as compared to controls. Percutaneous closure of Ventricular Septal Defect with Amplatzer occluders decreases the BNP levels

A comparative ID migraine screener study in ophthalmology, ENT and neurology out-patient clinics

Migraine is more likely to be misdiagnosed in patients with comorbid diseases. Not only primary care physicians, but also specialists might misdiagnose it due to the lack of diagnostic criteria awareness. The ID migraine test is a reliable screening instrument that may facilitate and accelerate migraine recognition. This study aimed to compare the prevalence and characteristics of migraine in a large sample of patients admitted to clinics of ophthalmology (OC), ear, nose and throat diseases (ENTC) and neurology (NC), as well as to validate the use of the ID migraine test in OC and ENTC settings. This was a multicentre (11 cites) study of out-patients admitting either to NC, ENTC or OC of the study sites during five consecutive working days within 1 week. From each of the clinics, 100 patients were planned to be recruited. All recruited patients were interviewed and those having a headache complaint received an ID migraine test and were examined for headache diagnosis by a neurologist, blinded to the ID migraine test result. A total of 2625 subjects were recruited. Only 1.3% of OC patients and 5.4% of ENTC patients have been admitted with a primary complaint of headache, whereas the percentage of NC patients suffering from headache was 37.6%. Whereas 138 patients (19.3%) in OC, 154 (17.3%) in ENTC and 347 (34%) in NC were found to be ID migraine test positive, 149 patients (20.8%) in OC, 142 (16%) in ENTC and 338 (33.1%) in NC were diagnosed with migraine. The sensitivity, specificity, and positive and negative predictive ratios of the ID migraine test were found to be similar in all clinics. An important fraction of the patients admitted to NC, as well as to OC and ENTC, for headache and/or other complaints were found out to have migraine by means of a simple screening test. This study validated the ID migraine test as a sensitive and specific tool in OC and ENTC, encouraging its use as a screening instrument.Pfizer-Türkiy

Kawasaki tanılı olguların izlemlerinde ventrikül fonksiyonlarının doku doppler ekokardiyografi ile değerlendirilmesi

Kawasaki hastalığı etyolojisi bilinmeyen, primer olarak 5 yaş altı çocuklarda izlenen akut febril bir vaskilittir. Tedavi edilmeyen olgularda %15 ile %25 oranında koroner arter anevrizması gelişmektedir. Koroner arter tutulumuna bağlı myokardial infarktüs, iskemik kalp hastalıkları ve ani ölüm izlenebilmektedir. Bu olguların izlemlerinde koroner arterlerdeki ektazi, anevrizma ve stenozu göstermek için kardiyak kateterizasyon, myokard perfüzyon sintigrafisi gibi invaziv girişimler kullanılmaktadır. Oysa ki koroner arterlerin beslediği lokalize bölgelerin fonksiyonlarının erken dönemde değerlendirilmesinde doku dopler ekokardiyografi gibi non invaziv testlere ihtiyaç duyulmaktadır. Biz çalışmamızda benzer yaş ve cinsiyet özelliklerine sahip 30 Kawasakili olgu ile 24 kontrol grubu vakasını doku doppler ekokardiyografi ile değerlendirdik. Kawasakili olgularımızın ortalama izlem süresi 24.53+19.06,22 ay idi. Kawasakili olguların akut hastalık sırasında 13'ünde koroner tutulum vardı. Koroner tutulum olan olguların 11 tanesi erkek, 2'si kız idi. İzlemlerinde olguların hiç birinde ekokardiyografi ile tespit edilebilir koroner arter anevrizması saptanmadı. Doku doppler ekokardiyografi ile değerlendirilen olgularımızda lateral ve septal duvar erken diastolik E' dalgası, atrial kontaksiyon A' dalgası, E'/A' oranı, sistolik S' dalgası, değerleri arasında anlamlı fark yoktu. Hasta grubunda sol ventrikül myokard performas indeksi (MPI) 0.518+0.028 iken kontrol grubunda MPI 0.497+0.028 idi. Hasta grubunda kontrol grubuna göre MPI istatistiksel olarak anlamlı şekilde yüksekti (p<0.011). Sonuç olarak Kawasakili olguların takiplerinde non invaziv bir yöntem olan doku doppler ekokardiyografi ile değerlendirmenin gelişebilecek uzun dönem komplikasyonların izlemi açısından yaralı olacağı düşüncesindeyiz

The Prevalence and Risk Factors of Anemia in Children with Renal Transplant

Objective: Anemia is commonly observed during the follow-ups of patients with renal transplantation. There is not enough information on anemia observed in children with renal transplantation. The aim of this study was to evaluate the prevalence and risk factors of anemia in children with renal transplantation on the short and long-term post- transplantation period. Material and Methods: This study was performed in children who underwent renal transplant at Ege University. Anemia was de;amp;#64257; ned as having a value less than 2 Standard Deviation for hematocrit levels according to age. Results: In the early post-transplant period, the incidence of anemia was found as 18%. Late post transplant anemia rate was detected as 27.5% at 60 months. The incidence of anemia was 18.4%, 23.3%, 23% and 27.5%, at 24, 36, 48 and 60 months after transplantation, respectively. Anemia was detected at least once in 71 (67.6%) patients at any point of the follow-up period. There was no correlation between Angiotensin Converting Enzyme inhibitor therapy and anemia at any post-transplant time. Donor type and donor age were not signi;amp;#64257; cantly associated with late anemia. On the other hand, late anemia was signi;amp;#64257; cantly associated with a history of rejection. Conclusion: Low estimated Glomerular Filtration Rate, longer duration of post-transplantation and rejection attacks are the risk factors for anemia in pediatric renal transplant recipients.Amaç: Renal transplantlı hastaların takibinde anemi yaygın görülmektedir. Renal transplantlı çocuklarda görülen anemi hakkında yeterli bilgi bulunmamaktadır. Bu çalışmanın amacı; transplantasyon sonrası çocuklarda kısa ve uzun dönem- de ortaya çıkan aneminin risk faktörlerini ve prevalansını değerlendirmektir. Gereç ve Yöntemler: Bu çalışma, Ege Üniversitesi’ndeki böbrek nakilli çocuklarda yapılmıştır. Hematokrit düzeyinin yaşa göre 2 standart deviasyon altında olması anemi olarak tanımlanmıştır. Bulgular: Erken post transplant dönemde anemi insidansı %18 bulundu. Geç post transplant dönemde ortalama ola- rak 60 ayda %27.5 oranda anemi saptandı. Anemi insidansı post transplant 24.36,48 ve 60. aylarda sırasıyla %18.4, %23.3, %23 ve %27.5 bulundu. Takip süresince herhangi bir zamanda 71 (%67.6) hastada en az bir kez anemi tespit edildi. Transplantasyon sonrası herhangi bir dönemde kullanılan ACE inhibitörü ile anemi arasında ilişki saptanmadı. Do- nör tipi ve yaşı ile geç anemi arasında anlamlı bir ilişki bulunmadı. Diğer yandan, geç dönem anemi rejeksiyon öyküsüyle anlamlı ilişkili bulundu. Sonuç: Renal transplant alıcısı olan çocuklarda tahmini glomerül ? ltrasyon hızının düşüklüğü, transplantasyon sonrası sürenin uzunluğu ve rejeksiyon atağı anemi için risk faktörleridir

Use of covered stents in simultaneous management of coarctation of the aorta and patent ductus arteriosus

WOS: 000429628000003PubMed ID: 29578201Objective: To report clinical and procedural characteristics of twelve patients who received a covered stent for the treatment of aortic coarctation and concurrent patent ductus arteriosus (PDA). Methods: A single center database was retrospectively evaluated to obtain data of patients with combined aortic coarctation and PDA. We selected patients in whom a covered stent was used for the treatment of both pathologies. The stent length was chosen so as to cover the entire length of the lesion from healthy to healthy tissue and also cover the ampulla of PDA. Results: The median age of the patients was 15 (range, 6.5-35) years. The diameter of the coarctated segment increased from a median of 8.4 (range, 2.6-10.8) mm to 16 (range, 9-24) mm (p<0.005), whereas the pressure gradient decreased from a median of 43 (range, 10-71) mm Hg to 0 (range, 0-8) mm Hg (p<0.005). Fourteen covered stents were used for 12 patients. Following deployment, seven stents were flared with larger and low-pressure balloons because of the gap between the distal end of the stent and the poststenotic dilated segment of the aorta, which caused residual PDA shunts and/or instability of the stent. After the procedure, no residual PDA shunt was present in any patient. Conclusion: To the best of our knowledge, this study includes the largest series of patients reported in literature in whom covered CP stents were used for simultaneous percutaneous treatment of coarctation and PDA. The procedure was successful and stable results were obtained during follow-up in all cases