Toward a dynamical systems analysis of neuromodulation

This work presents some first steps toward a more thorough understanding of the control systems employed in evolutionary robotics. In order to choose an appropriate architecture or to construct an effective novel control system we need insights into what makes control systems successful, robust, evolvable, etc. Here we present analysis intended to shed light on this type of question as it applies to a novel class of artificial neural networks that include a neuromodulatory mechanism: GasNets. We begin by instantiating a particular GasNet subcircuit responsible for tuneable pattern generation and thought to underpin the attractive property of “temporal adaptivity”. Rather than work within the GasNet formalism, we develop an extension of the well-known FitzHugh-Nagumo equations. The continuous nature of our model allows us to conduct a thorough dynamical systems analysis and to draw parallels between this subcircuit and beating/bursting phenomena reported in the neuroscience literature. We then proceed to explore the effects of different types of parameter modulation on the system dynamics. We conclude that while there are key differences between the gain modulation used in the GasNet and alternative schemes (including threshold modulation of more traditional synaptic input), both approaches are able to produce tuneable pattern generation. While it appears, at least in this study, that the GasNet’s gain modulation may not be crucial to pattern generation , we go on to suggest some possible advantages it could confer

The Local Group: The Ultimate Deep Field

Near-field cosmology -- using detailed observations of the Local Group and its environs to study wide-ranging questions in galaxy formation and dark matter physics -- has become a mature and rich field over the past decade. There are lingering concerns, however, that the relatively small size of the present-day Local Group ($\sim 2$ Mpc diameter) imposes insurmountable sample-variance uncertainties, limiting its broader utility. We consider the region spanned by the Local Group's progenitors at earlier times and show that it reaches $3' \approx 7$ co-moving Mpc in linear size (a volume of $\approx 350\,{\rm Mpc}^3$) at $z=7$. This size at early cosmic epochs is large enough to be representative in terms of the matter density and counts of dark matter halos with $M_{\rm vir}(z=7) \lesssim 2\times 10^{9}\,M_{\odot}$. The Local Group's stellar fossil record traces the cosmic evolution of galaxies with $10^{3} \lesssim M_{\star}(z=0) / M_{\odot} \lesssim 10^{9}$ (reaching $M_{1500} > -9$ at $z\sim7$) over a region that is comparable to or larger than the Hubble Ultra-Deep Field (HUDF) for the entire history of the Universe. It is highly complementary to the HUDF, as it probes much fainter galaxies but does not contain the intrinsically rarer, brighter sources that are detectable in the HUDF. Archaeological studies in the Local Group also provide the ability to trace the evolution of individual galaxies across time as opposed to evaluating statistical connections between temporally distinct populations. In the JWST era, resolved stellar populations will probe regions larger than the HUDF and any deep JWST fields, further enhancing the value of near-field cosmology.Comment: 6 pages, 5 figures; MNRAS Letters, in pres

Calcitonin Gene-Related Peptide Receptor Antagonists: Beyond Migraine Pain—A Possible Analgesic Strategy for Osteoarthritis?

Osteoarthritis (OA) pain is poorly understood and managed, as current analgesics have only limited efficacy and unwanted side effect profiles. A broader understanding of the pathological mechanisms driving OA joint pain is vital for the development of improved analgesics. Both clinical and preclinical data suggest an association between joint levels of the sensory neuropeptide calcitonin gene-related peptide (CGRP) and pain during OA. Whether a direct causative link exists remains an important unanswered question. Given the recent development of small molecule CGRP receptor antagonists with clinical efficacy against migraine pain, the interrogation of the role of CGRP in OA pain mechanisms is extremely timely. In this article, we provide the background to the importance of CGRP in pain mechanisms and review the emerging clinical and preclinical evidence implicating a role for CGRP in OA pain. We suggest that the CGRP receptor antagonists developed for migraine pain warrant further investigation in OA

Living in Plurilingual Spaces: Self-Study, Critical Friendship, and the Plurality of Publics

In this article we engage in collaborative self-study through a critical friendship that is specifically designed to evoke our personal histories in relation to how we approach our practices as teacher educators. In particular, we focus on understanding the conceptual origins of our pedagogies of teacher education and how our identities as teacher educators were shaped, and continue to be shaped, by colleagues, teacher candidates, and by the process of self-study itself. We argue that the multiple studies that are available to any self-study research program creates a plurality of publics in which we identify, and are identified, in particular ways by particular members of the teacher education community. One significant avenue for our developing line of work concerns the ways in which our shared bilingualism plays out during our critical friendship, and how the use of multiple languages helps us to reframe our identities as teacher educators, particularly whilst engaged in translanguaging practices

The Mass Dependance of Satellite Quenching in Milky Way-like Halos

Using the Sloan Digital Sky Survey, we examine the quenching of satellite galaxies around isolated Milky Way-like hosts in the local Universe. We find that the efficiency of satellite quenching around isolated galaxies is low and roughly constant over two orders of magnitude in satellite stellar mass ($M_{*}$ = $10^{8.5}-10^{10.5} \, M_{\odot}$), with only $\sim~20\%$ of systems quenched as a result of environmental processes. While largely independent of satellite stellar mass, satellite quenching does exhibit clear dependence on the properties of the host. We show that satellites of passive hosts are substantially more likely to be quenched than those of star-forming hosts, and we present evidence that more massive halos quench their satellites more efficiently. These results extend trends seen previously in more massive host halos and for higher satellite masses. Taken together, it appears that galaxies with stellar masses larger than about $10^{8}~M_{\odot}$ are uniformly resistant to environmental quenching, with the relative harshness of the host environment likely serving as the primary driver of satellite quenching. At lower stellar masses ($< 10^{8}~M_{\odot}$), however, observations of the Local Group suggest that the vast majority of satellite galaxies are quenched, potentially pointing towards a characteristic satellite mass scale below which quenching efficiency increases dramatically.Comment: 14 pages, 8 figure