365 research outputs found

    Heinrich Bullinger

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    Im Geist der Reformation verstand Heinrich Bullinger Theologie in erster Linie als Auslegung der Heiligen Schrift. Mit diesem Band – dem neunten in der Reihe seiner Theologischen Schriften – wird die Edition seiner Kommentare zu den neutestamentlichen Briefen abgeschlossen. Darin enthalten sind die Auslegungen des Briefs an die HebrĂ€er sowie der Katholischen Briefe. Die Texte sind anhand der Erstauflage sowie der ersten Gesamtausgabe der Kommentare Bullingers zu den neutestamentlichen Briefen (1537) historisch-kritisch ediert worden. Erschlossen wird die Edition durch eine Einleitung und insgesamt vier Register (Bibelstellen, Quellen, Personen und Orte)

    Dispositio Et Perioche Historiae Evangelicae Per IIII. Euangelistas contextĂŠ, necnon Actuum apostoloru[m], Epistolaru[m] quoq[ue] Pauli XIIII. & Canonicaru[m] VII.

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    ex Commentarijs H. Bullingeri petita, & in forma[m] enchiridij redacta ...Vorlageform des Erscheinungsvermerks: Tigvri Excvdebat Christophorus Froschouerus mense Ianuario, M. D. LIII

    Approximations and their consequences for dynamic modelling of signal transduction pathways

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    Signal transduction is the process by which the cell converts one kind of signal or stimulus into another. This involves a sequence of biochemical reactions, carried out by proteins. The dynamic response of complex cell signalling networks can be modelled and simulated in the framework of chemical kinetics. The mathematical formulation of chemical kinetics results in a system of coupled differential equations. Simplifications can arise through assumptions and approximations. The paper provides a critical discussion of frequently employed approximations in dynamic modelling of signal transduction pathways. We discuss the requirements for conservation laws, steady state approximations, and the neglect of components. We show how these approximations simplify the mathematical treatment of biochemical networks but we also demonstrate differences between the complete system and its approximations with respect to the transient and steady state behavior

    The German MultiCare-study: Patterns of multimorbidity in primary health care – protocol of a prospective cohort study

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    Background Multimorbidity is a highly frequent condition in older people, but well designed longitudinal studies on the impact of multimorbidity on patients and the health care system have been remarkably scarce in numbers until today. Little is known about the long term impact of multimorbidity on the patients' life expectancy, functional status and quality of life as well as health care utilization over time. As a consequence, there is little help for GPs in adjusting care for these patients, even though studies suggest that adhering to present clinical practice guidelines in the care of patients with multimorbidity may have adverse effects. Methods The study is designed as a multicentre prospective, observational cohort study of 3.050 patients aged 65 to 85 at baseline with at least three different diagnoses out of a list of 29 illnesses and syndromes. The patients will be recruited in approx. 120 to 150 GP surgeries in 8 study centres distributed across Germany. Information about the patients' morbidity will be collected mainly in GP interviews and from chart reviews. Functional status, resources/risk factors, health care utilization and additional morbidity data will be assessed in patient interviews, in which a multitude of well established standardized questionnaires and tests will be performed. Discussion The main aim of the cohort study is to monitor the course of the illness process and to analyse for which reasons medical conditions are stable, deteriorating or only temporarily present. First, clusters of combinations of diseases/disorders (multimorbidity patterns) with a comparable impact (e.g. on quality of life and/or functional status) will be identified. Then the development of these clusters over time will be analysed, especially with regard to prognostic variables and the somatic, psychological and social consequences as well as the utilization of health care resources. The results will allow the development of an instrument for prediction of the deterioration of the illness process and point at possibilities of prevention. The practical consequences of the study results for primary care will be analysed in expert focus groups in order to develop strategies for the inclusion of the aspects of multimorbidity in primary care guidelines

    In piam et eruditam Pauli ad Hebraeos epistolam Heinrychi Bullingeri commentarius. ...

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    Bogensignaturen: A-R⁞, SÂč

    GÀgenbericht Heinrychen Bullingers uff den Bericht Herren Johansen Brentzen von dem Himmel unnd der GerÀchten Gottes. ...

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    Impressum gemÀss VischerBogensignaturen: A-P

    De prophetae officio, et quomodo digne administrari possit, oratio

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    Heinrycho Bullingero authore. ...Impressum gemÀss KolophonBogensignaturen: A-D⁞, E
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