Neural network interpolation of the magnetic field for the LISA Pathfinder Diagnostics Subsystem

LISA Pathfinder is a science and technology demonstrator of the European Space Agency within the framework of its LISA mission, which aims to be the first space-borne gravitational wave observatory. The payload of LISA Pathfinder is the so-called LISA Technology Package, which is designed to measure relative accelerations between two test masses in nominal free fall. Its disturbances are monitored and dealt by the diagnostics subsystem. This subsystem consists of several modules, and one of these is the magnetic diagnostics system, which includes a set of four tri-axial fluxgate magnetometers, intended to measure with high precision the magnetic field at the positions of the test masses. However, since the magnetometers are located far from the positions of the test masses, the magnetic field at their positions must be interpolated. It has been recently shown that because there are not enough magnetic channels, classical interpolation methods fail to derive reliable measurements at the positions of the test masses, while neural network interpolation can provide the required measurements at the desired accuracy. In this paper we expand these studies and we assess the reliability and robustness of the neural network interpolation scheme for variations of the locations and possible offsets of the magnetometers, as well as for changes in environmental conditions. We find that neural networks are robust enough to derive accurate measurements of the magnetic field at the positions of the test masses in most circumstances

Bridge distress caused by approach embankment settlement

Surtees Bridge, which carries the A66(T) over the River Tees near Thornaby-on-Tees in the UK, has been showing signs of distress that predate its opening in 1981. Subsequent investigations have shown that the bridge distress is related to unexpectedly large settlement of the eastern approach embankment. Recent ground investigations prompted by a proposed widening of the river crossing have produced many new data on the alluvial deposits underlying the site, and explain why embankment settlement was so much larger than originally anticipated. Comparison of the geotechnical parameters obtained from the original and more recent ground investigations suggests that the original investigation significantly underestimated the thickness of an alluvial clay layer underlying the site, and that its coefficient of consolidation was overestimated. Settlement analyses using geotechnical data from the original ground investigations predict moderate embankment settlements occurring principally during construction. Settlement analyses based on all the available data predict far larger embankment settlements occurring over extended time periods. The latter analyses predict an embankment settlement similar to that observed and of sufficient magnitude to cause the observed lateral displacement of the bridge due to lateral loading of its piled foundation

UK Large-scale Wind Power Programme from 1970 to 1990: the Carmarthen Bay experiments and the Musgrove Vertical-Axis Turbines

This article describes the development of the Musgrove Vertical Axis Wind Turbine (VAWT) concept, the UK ‘Carmarthen Bay’ wind turbine test programme, and UK government’s wind power programme to 1990. One of the most significant developments in the story of British wind power occurred during the 1970s, 1980s, and 1990s, with the development of the Musgrove vertical axis wind turbine and its inclusion within the UK Government’s wind turbine test programme. Evolving from a supervisor’s idea for an undergraduate project at Reading University, the Musgrove VAWT was once seen as an able competitor to the horizontal axis wind systems that were also being encouraged at the time by both the UK government and the Central Electricity Generating Board, the then nationalised electricity utility for England and Wales. During the 1980s and 1990s the most developed Musgrove VAWT system, along with three other commercial turbine designs was tested at Carmarthen Bay, South Wales as part of a national wind power test programme. From these developmental tests, operational data was collected and lessons learnt, which were incorporated into subsequent wind power operations.http://dx.doi.org/10.1260/03095240677860621

Study protocol for a randomised trial of nicotine-free cigarettes as an adjunct to usual NRT-based cessation practice, in people who wish to stop smoking

This trial is funded by a programme grant from the Health Research Council of New Zealand.

Salmonella biofilms

Biofilm formation by Salmonellaspp. is a problem in the food industry, since biofilms may act as a persistent source of product contamination. Therefore the aim of this study was to obtain more insight in the processes involved and the factors contributing to Salmonellabiofilm formation. A collection of SalmonellaTyphimurium clinical, outbreak-related and retail product isolates, was used to determine biofilm formation capacity and to identify cellular parameters contributing to surface colonisation. The results revealed dense biofilm formation by these isolates at 25 °C and 37 °C in nutrient-rich media. However, in nutrient-low media dense biofilm formation was only observed at 25 °C with industrial isolates. In addition, temperature and medium composition were also found to influence biofilm morphology and composition. At nutrient-low conditions at 25 °C the biofilm consisted of cell clusters encapsulated by an extracellular matrix composed of curli fimbriae and cellulose. In nutrient-rich conditions a monolayer of cells with little to no extracellular matrix were observed, with a prominent role for type 1 fimbriae. This type of fimbriae was only expressed in a subset of strains and appeared to contribute to initial attachment of Salmonellacells ultimately leading to dense biofilm formation. This study also indicated that biofilm formation differs between and within the Salmonellaserovars Typhimurium, Derby, Brandenburg and Infantis, isolated from meat processing environments. And, for all serovars biofim formation contributed to the survival on stainless steel surfaces and biofilm cells were less susceptible to peracetic acid disinfection treatments. This latter effect was specifically observed in the presence of organic matter, which drastically decreased the activity of peracetic acid conceivably resulting in low level exposure of the bacterial flora facilitating survival. Furthermore, single and repeated exposure to sub-lethal concentrations of the disinfectant benzalkonium chloride rapidly selected for resistant variants. In conclusion, the results obtained in this study may contribute to the development of better strategies for Salmonella control in food processing environments.</p

Geophysical studies with laser-beam detectors of gravitational waves

The existing high technology laser-beam detectors of gravitational waves may find very useful applications in an unexpected area - geophysics. To make possible the detection of weak gravitational waves in the region of high frequencies of astrophysical interest, ~ 30 - 10^3 Hz, control systems of laser interferometers must permanently monitor, record and compensate much larger external interventions that take place in the region of low frequencies of geophysical interest, ~ 10^{-5} - 3 X 10^{-3} Hz. Such phenomena as tidal perturbations of land and gravity, normal mode oscillations of Earth, oscillations of the inner core of Earth, etc. will inevitably affect the performance of the interferometers and, therefore, the information about them will be stored in the data of control systems. We specifically identify the low-frequency information contained in distances between the interferometer mirrors (deformation of Earth) and angles between the mirrors' suspensions (deviations of local gravity vectors and plumb lines). We show that the access to the angular information may require some modest amendments to the optical scheme of the interferometers, and we suggest the ways of doing that. The detailed evaluation of environmental and instrumental noises indicates that they will not prevent, even if only marginally, the detection of interesting geophysical phenomena. Gravitational-wave instruments seem to be capable of reaching, as a by-product of their continuous operation, very ambitious geophysical goals, such as observation of the Earth's inner core oscillations.Comment: 29 pages including 8 figures, modifications and clarifications in response to referees' comments, to be published in Class. Quant. Gra

Turning collegial governance on its head : symbolic violence, hegemony and the academic board

This article draws on Bourdieu&rsquo;s theorisation of domination and Gramsci&rsquo;s notions of hegemony within the context of a larger empirical study of Australian university academic governance, and of academic boards (also known as academic senates or faculty senates) in particular. Reporting data that suggest a continued but radically altered form of collegial governance in which hegemony is exercised by management rather than by the professor, it theorises the domination of academic boards within western democratic universities. However, traditional collegial governance is also dependent upon a community of scholars, a role historically played by the academic board. In view of the suggested transition in collegial governance and the resultant convergence of academic work and management, the article concludes with questions about whether academic boards can continue to serve as communities of scholars in future

Solar System Processes Underlying Planetary Formation, Geodynamics, and the Georeactor

Only three processes, operant during the formation of the Solar System, are responsible for the diversity of matter in the Solar System and are directly responsible for planetary internal-structures, including planetocentric nuclear fission reactors, and for dynamical processes, including and especially, geodynamics. These processes are: (i) Low-pressure, low-temperature condensation from solar matter in the remote reaches of the Solar System or in the interstellar medium; (ii) High-pressure, high-temperature condensation from solar matter associated with planetary-formation by raining out from the interiors of giant-gaseous protoplanets, and; (iii) Stripping of the primordial volatile components from the inner portion of the Solar System by super-intense solar wind associated with T-Tauri phase mass-ejections, presumably during the thermonuclear ignition of the Sun. As described herein, these processes lead logically, in a causally related manner, to a coherent vision of planetary formation with profound implications including, but not limited to, (a) Earth formation as a giant gaseous Jupiter-like planet with vast amounts of stored energy of protoplanetary compression in its rock-plus-alloy kernel; (b) Removal of approximately 300 Earth-masses of primordial gases from the Earth, which began Earth's decompression process, making available the stored energy of protoplanetary compression for driving geodynamic processes, which I have described by the new whole-Earth decompression dynamics and which is responsible for emplacing heat at the mantle-crust-interface at the base of the crust through the process I have described, called mantle decompression thermal-tsunami; and, (c)Uranium accumulations at the planetary centers capable of self-sustained nuclear fission chain reactions.Comment: Invited paper for the Special Issue of Earth, Moon and Planets entitled Neutrino Geophysics Added final corrections for publicatio

Longer-term use of electronic cigarettes when provided as a stop smoking aid: Systematic review with meta-analyses.

Moderate certainty evidence supports use of nicotine electronic cigarettes to quit smoking combustible cigarettes. However, there is less certainty regarding how long people continue to use e-cigarettes after smoking cessation attempts. We set out to synthesise data on the proportion of people still using e-cigarettes or other study products at 6 months or longer in studies of e-cigarettes for smoking cessation. We updated Cochrane searches (November 2021). For the first time, we meta-analysed prevalence of continued e-cigarette use among individuals allocated to e-cigarette conditions, and among those individuals who had successfully quit smoking. We updated meta-analyses comparing proportions continuing product use among individuals allocated to use nicotine e-cigarettes and other treatments. We included 19 studies (n = 7787). The pooled prevalence of continued e-cigarette use at 6 months or longer was 54% (95% CI: 46% to 61%, I2 86%, N = 1482) in participants assigned to e-cigarette conditions. Of participants who had quit combustible cigarettes overall 70% were still using e-cigarettes at six months or longer (95% CI: 53% to 82%, I2 73%, N = 215). Heterogeneity in direction of effect precluded meta-analysis comparing long-term use of nicotine e-cigarettes with NRT. More people were using nicotine e-cigarettes at longest follow-up compared to non-nicotine e-cigarettes, but CIs included no difference (risk ratio 1.15, 95% CI: 0.94 to 1.41, n = 601). The levels of continued e-cigarette use observed may reflect the success of e-cigarettes as a quitting tool. Further research is needed to establish drivers of variation in and implications of continued use of e-cigarettes

Biogenesis of the inner membrane complex is dependent on vesicular transport by the alveolate specific GTPase Rab11B

Apicomplexan parasites belong to a recently recognised group of protozoa referred to as Alveolata. These protists contain membranous sacs (alveoli) beneath the plasma membrane, termed the Inner Membrane Complex (IMC) in the case of Apicomplexa. During parasite replication the IMC is formed de novo within the mother cell in a process described as internal budding. We hypothesized that an alveolate specific factor is involved in the specific transport of vesicles from the Golgi to the IMC and identified the small GTPase Rab11B as an alveolate specific Rab-GTPase that localises to the growing end of the IMC during replication of Toxoplasma gondii. Conditional interference with Rab11B function leads to a profound defect in IMC biogenesis, indicating that Rab11B is required for the transport of Golgi derived vesicles to the nascent IMC of the daughter cell. Curiously, a block in IMC biogenesis did not affect formation of sub-pellicular microtubules, indicating that IMC biogenesis and formation of sub-pellicular microtubules is not mechanistically linked. We propose a model where Rab11B specifically transports vesicles derived from the Golgi to the immature IMC of the growing daughter parasites