Sir Charles Lyell's travels in New Brunswick, Canada, in 1852

Abstract Geologist Sir Charles Lyell made a brief visit to New Brunswick, Canada, during his 1852 visit to North America. Lyell traveled to Albert Mines during the peak of the albertite controversy, visited the Reversing Falls and graphite mines in Saint John, and took a steamboat trip up the Saint John River to Fredericton where he visited his friend, Lieutenant Governor Sir Edmund Head. Lyell’s friendship with Head likely had a long-term effect on the development of geological sciences in New Brunswick and Canada. New Brunswick newspapers followed Charles Lyell’s travels through the province and expressed hope that Lyell’s observations on the geology of New Brunswick would cast a favourable opinion on the province’s geological wealth and foster economic development. Résumé Le géologue Sir Charles Lyell a effectué un bref arrêt au Nouveau-Brunswick, Canada, au cours de sa visite de 1852 en Amérique du Nord. Lyell s’est rendu à Albert Mines au moment culminant de la controverse au sujet de l’albertite; il a visité les chutes réversibles et les mines de graphite de Saint-Jean; et il a remonté en vapeur le fleuve Saint-Jean jusqu’à Fredericton, où il a rendu visite à son ami, le lieutenant-gouverneur Sir Edmund Head. L’amitié de Lyell et Head a probablement eu un effet de longue durée sur l’essor des sciences de la terre au Nouveau-Brunswick et au Canada. Les journaux du Nouveau-Brunswick ont suivi les déplacements de Charles Lyell à l’intérieur de la province; ils ont exprimé l’espoir que les observations de Lyell sur la géologie du Nouveau-Brunswick engendreraient une opinion favorable sur la richesse géologique de la province et qu’elles favoriseraient le développement économique

Gesner’s Museum of Natural History, An Early Canadian Geological Collection

In 1842, on the fifth of April, Abraham Gesner opened the doors of his museum in Saint John, New Brunswick to the public. The museum displayed part of his collection of almost 4,000 specimens. His published catalogue included more than 1,200 rocks, minerals and fossils along with a smaller number of invertebrate and vertebrate animals and artefacts. It survives today as one of Canada’s oldest geological collections. This national treasure documents the earliest days of the study of the geological sciences in Canada including specimens from Gesner’s surveys of New Brunswick and Nova Scotia. Although Gesner’s collection moved through three institutions, it has remained partly intact and is accompanied by a catalogue of the museum’s contents. SOMMAIRE Le 5 avril 1842, Abraham Gesner ouvrait au public son musée à Saint-Jean, Nouveau-Brunswick. Le musée exposait alors une partie de sa collection de près de 4 000 spécimens. Le catalogue qu'il a publié alors comprenait plus de 1 200 roches, minéraux et fossiles ainsi qu'un nombre moindre de spécimens de vertébrés, d'invertébrés et d'artéfacts. Il a survécu jusqu'à nos jours et constitue l'une des plus anciennes collections géologiques au Canada. Ce trésor canadien qui témoigne des premières études scientifiques de la géologie au Canada comprend des spécimens tirés de levés effectués par Gesner au Nouveau-Brunswick et en Nouvelle-Écosse. Bien que la collection de Gesner ait été déplacée dans trois institutions, elle demeure encore partiellement intacte et comporte un catalogue de ses spécimens

Effects of protein source and fat level on performance, growth of the pancreas, stomach, and small intestine, and on pancreatic enzyme activity and gene expression in early-weaned pigs

Scope and Method of Study: Two experiments were conducted to determine the effects of reducing ME (fat) level in diets containing soy protein concentrate (SPC) or spray-dried porcine plasma (SDPP) on performance of 400 crossbred pigs (avg BW = 5.8 kg; avg 21 d). In Exp.1, pigs were allotted to four dietary treatments (6-7 pigs/pen, 9 replications) in RCBD: 1) SPC, ME = 3,471 kcal/kg, 2) SDPP, ME = 3,471, 3) SDPP, ME = 3,371, and 4) SDPP, ME = 3,271. In Exp. 2, a 2 x 2 factorial in RCBD (7 pigs/pen, 6 replications) was used: 1) SPC with ME = 3,523, 2) SPC, ME = 3,323, 3) SDPP, ME = 3,523, and 4) SDPP, ME = 3,323. Pigs and feeders were weighed on d 0, 7, 14, and 18, to determine ADG, ADFI, and G:F. Exp. 3 was performed using Exp. 2 treatment design (4 pigs/ trt, 5 reps, avg BW = 6.1 kg; avg 18 d) to determine the effect on growth of the pancreas, stomach, and small intestine, morphology of the small intestine, levels of IgG and IgA in serum and intestinal chyme, pancreatic a-amylase and triglyceride lipase activities in pancreas and chyme, and gene expression of triglyceride lipase, a-amylase and trypsinogen.Findings and Conclusions: Inclusion of SDPP in weanling pig diets improved ADG, ADFI, and G:F. Reducing ME level in SDPP diets did not affect growth performance, but linearly increased weight gain/ME intake. The improvement in weight gain/ME intake associated with reduced ME tended to be greater for pigs fed SPC than for pigs fed SDPP. Protein source or fat level did not affect lipase and amylase activity in pancreas, but SDPP increased these in intestinal chyme. CP source increased gene expression of amylase and numerically increased lipase and trypsinogen expression. Intestinal chyme IgG was significantly increased in pigs fed SDPP. Results suggest that inclusion of SDPP to weanling pig diets improves growth performance by varied mechanisms. In addition, the use of fat in weanling pig diets during the first 2 wk post-weaning may have no benefit to pig growth

Use Study of Oklahoma State University Division of Public Information Hometown News Releases to Oklahoma Newspapers from July 1, 1979 to June 30, 1980

Mass Communication

The ethnic basis of national identity in Italy

Іtalians say that firstly they are Venetians, Neapolitans, Piedmonts, Florentines, Europeans and finally they are the Italians. They have something in common such sa cappuccino, pizza and football of course when it says about the national football team. It is hard to find a country in Europe where people engage with each other but it is Italy. Citizens don’t agree with the Risorgimento or Italian unification. In southern Italy people think that the unification has led to the expropriation their wealth by the northern Italians. On the other hard the northern Italians are sure that it’s better to depend on Viennese authorities than corrupt Roman authorities

Characterization of IXINITY (Trenonacog Alfa), a Recombinant Factor IX with Primary Sequence Corresponding to the Threonine-148 Polymorph

The goal of these studies was to extensively characterize the first recombinant FIX therapeutic corresponding to the threonine-148 (Thr-148) polymorph, IXINITY (trenonacog alfa [coagulation factor IX (recombinant)]). Gel electrophoresis, circular dichroism, and gel filtration were used to determine purity and confirm structure. Chromatographic and mass spectrometry techniques were used to identify and quantify posttranslationalmodifications. Activity was assessed as the ability to activate factor X (FX) both with and without factor VIIIa (FVIIIa) and in a standard clotting assay. All results were consistent across multiple lots. Trenonacog alfa migrated as a single band onCoomassie-stained gels; activity assayswere normal and showed97% -carboxylation and underwent the appropriate structural change upon binding calcium ions. Trenonacog alfa was activated normally with factor XIa (FXIa); once activated it bound to FVIIIa and FXa. When activated to FIXa, it was inhibited efficiently by antithrombin. Glycosylation patterns were similar to plasma-derived FIX with sialic acid content consistent with the literature reports of good pharmacokinetic performance. These studies have shown that trenonacog alfa is a highly pure product with a primary sequence and posttranslational modifications consistent with the common Thr-148 polymorphism of plasma-derived FIX

Characterization of IXINITY (Trenonacog Alfa), a Recombinant Factor IX with Primary Sequence Corresponding to the Threonine-148 Polymorph

The goal of these studies was to extensively characterize the first recombinant FIX therapeutic corresponding to the threonine-148 (Thr-148) polymorph, IXINITY (trenonacog alfa [coagulation factor IX (recombinant)]). Gel electrophoresis, circular dichroism, and gel filtration were used to determine purity and confirm structure. Chromatographic and mass spectrometry techniques were used to identify and quantify posttranslationalmodifications. Activity was assessed as the ability to activate factor X (FX) both with and without factor VIIIa (FVIIIa) and in a standard clotting assay. All results were consistent across multiple lots. Trenonacog alfa migrated as a single band onCoomassie-stained gels; activity assayswere normal and showed97% -carboxylation and underwent the appropriate structural change upon binding calcium ions. Trenonacog alfa was activated normally with factor XIa (FXIa); once activated it bound to FVIIIa and FXa. When activated to FIXa, it was inhibited efficiently by antithrombin. Glycosylation patterns were similar to plasma-derived FIX with sialic acid content consistent with the literature reports of good pharmacokinetic performance. These studies have shown that trenonacog alfa is a highly pure product with a primary sequence and posttranslational modifications consistent with the common Thr-148 polymorphism of plasma-derived FIX