2,383 research outputs found
Role of hormonal risk factors in HER2-positive breast carcinomas
Examination of parity, age at menarche and at menopause by HER2 status in a large series of breast carcinomas showed a statistically significant increased-frequency of HER2-positive tumours in lower risk subgroups. The findings suggest a difference in the protective role of hormone-related risk factors between HER2-positive and -negative tumour
Prognosis based on primary breast carcinoma instead of pathological nodal status.
In breast cancer patients, prognostic information required to plan post-surgical therapy is obtained mainly through axillary dissection. This study was designed to establish a new prognostic score based solely on parameters of the primary tumour as an alternative to axillary surgery in assessing prognosis. Eight different prognostic factors, including menopausal status, tumour size, grading, lymphatic invasion, desmoplasia, necrosis, c-erbB-2 and laminin receptor expression, were evaluated retrospectively on a large series of primary breast carcinoma patients. From multivariate analysis, four independent parameters were selected and examined, alone and in combination, for their prognostic potential. These parameters were used to generate a prognostic score that was analysed retrospectively in 467 N0-N1a patients to determine its predictive value for survival. The score, which includes variables such as tumour size, grading, laminin receptor and c-erbB-2 overexpression, was established based on the number of negative prognostic factors: score 1 refers to cases in which all four parameters reflect a good prognosis, scores 2 and 3 refer to tumours in which, respectively, one or two of the four parameters reflect a poor prognosis, whereas score 4 refers to tumours with three or four poor prognosis factors. Analysis of the overall survival of the four score groups shows that patients with score 1 tumours (22% of the total) had the best prognosis with a 15 year survival of 82%, patients with score 2 and 3 had an intermediate prognosis, whereas score 4 patients had the poorest prognosis with a 15 year survival of only 38%. Moreover, survival in the N+ score 1 cases was found to be longer than that in the total N- patients. Our data suggest that the primary tumour score provides more reliable prognostic information than pathological nodal status, and that axillary dissection can be avoided in a large number of patients
Identification of HER2-positive breast carcinomas as a particular subset with peculiar clinical behaviours
Status of cosmic-ray antideuteron searches
The precise measurement of cosmic-ray antiparticles serves as important means
for identifying the nature of dark matter. Recent years showed that identifying
the nature of dark matter with cosmic-ray positrons and higher energy
antiprotons is difficult, and has lead to a significantly increased interest in
cosmic-ray antideuteron searches. Antideuterons may also be generated in dark
matter annihilations or decays, offering a potential breakthrough in unexplored
phase space for dark matter. Low-energy antideuterons are an important approach
because the flux from dark matter interactions exceeds the background flux by
more than two orders of magnitude in the low-energy range for a wide variety of
models. This review is based on the "dbar14 - dedicated cosmic-ray antideuteron
workshop", which brought together theorists and experimentalists in the field
to discuss the current status, perspectives, and challenges for cosmic-ray
antideuteron searches and discusses the motivation for antideuteron searches,
the theoretical and experimental uncertainties of antideuteron production and
propagation in our Galaxy, as well as give an experimental cosmic-ray
antideuteron search status update. This report is a condensed summary of the
article "Review of the theoretical and experimental status of dark matter
identification with cosmic-ray antideuteron" (arXiv:1505.07785).Comment: 9 pages, 4 figures, ICRC 2015 proceeding
New detectors for the kaon and hypernuclear experiments with KaoS at MAMI and with PANDA at GSI
The KaoS spectrometer at the Mainz Microtron MAMI, Germany, is perceived as
the ideal candidate for a dedicated spectrometer in kaon and hypernuclei
electroproduction. KaoS will be equipped with new read-out electronics, a
completely new focal plane detector package consisting of scintillating fibres,
and a new trigger system. First prototypes of the fibre detectors and the
associated new front-end electronics are shown in this contribution. The Mainz
hypernuclei research program will complement the hypernuclear experiments at
the planned FAIR facility at GSI, Germany. At the proposed antiproton storage
ring the spectroscopy of double Lambda hypernuclei is one of the four main
topics which will be addressed by the PANDA Collaboration. The experiments
require the operation of high purity germanium (HPGe) detectors in high
magnetic fields (B= 1T) in the presence of a large hadronic background. The
performance of high resolution Ge detectors in such an environment has been
investigated.Comment: Presentation at International Symposium on the Development of
Detectors for Particle, Astroparticle and Synchrotron Radiation Experiments,
Stanford, Ca (SNIC06), 6 pages, LaTeX, 11 eps figure
Real-Time PM10 Emission Rates From Paved Roads by Measurement of Concentrations in the Vehicle\u27s Wake Using On-Board Sensors Part 1. SCAMPER Method Characterization
Based on emission factors derived from the AP-42 algorithm, particulate matter from paved roads has been estimated to be a major source of PM10 of geologic origin. This is an empirical formula based on upwind-downwind measurement of PM10 concentrations and is dependent solely on the silt loading of the pavement and the weight of vehicles. A number of upwind-downwind studies conducted in urban areas to validate this algorithm have been generally inconclusive because the PM10 concentration difference between upwind and downwind often is within the measurement uncertainty. In the approach presented here PM10 concentrations were measured directly behind a moving vehicle in order to improve the measurement sensitivity for estimating the emission rates for vehicles on paved roads. Optical sensors were used to measure PM10 concentrations with a time resolution of approximately 10 s. Sensors were mounted in the front of the vehicle and behind it in the well-mixed wake. A special inlet probe was designed to allow isokinetic sampling under varying speed conditions. As a first approximation the emission rate was calculated by multiplying the PM10 concentration difference between the front and rear of a moving vehicle by the frontal area of the vehicle. This technique is also useful for quickly surveying large areas and for investigating hot spots on roadways caused by greater than normal deposition of PM10 forming debris. The method is designated as SCAMPER: System for the Continuous Aerosol Measurement of Particulate Emissions from Roads. Part I describes SCAMPER development and Part II describes a comprehensive field testing of mobile methods
First determination of the one-proton induced Non-Mesonic Weak Decay width of p-shell {\Lambda}-Hypernuclei
Previous studies of proton and neutron spectra from Non-Mesonic Weak Decay of
eight Lambda-Hypernuclei (A = 5-16) have been revisited. New values of the
ratio of the two-nucleon and the one-proton induced decay widths,
Gamma_2N/Gamma_p, are obtained from single proton spectra, Gamma_2N/Gamma_p =
0.50 +/- 0.24, and from neutron and proton coincidence spectra,
Gamma_2N/Gamma_p = 0.36 +/- 0.14stat +0.05sys -0.04sys , in full agreement with
previously published ones. With these values, a method is developed to extract
the one-proton induced decay width in units of the free Lambda decay width,
Gamma_p/Gamma_Lambda, without resorting to Intra Nuclear Cascade models but by
exploiting only experimental data, under the assumption of a linear dependence
on A of the Final State Interaction contribution. This is the first systematic
determination ever done and it agrees within the errors with recent theoretical
calculations.Comment: 16 pages, 3 figures, 2 table
emission rates in absorptions at rest on Li, Li, Be, C and O
An experimental study of the reaction
on Li, Li, Be, C and O -shell nuclei is
presented. The data were collected by the FINUDA spectrometer operating at the
DANE -factory (LNF-INFN, Italy). Emission rates for the reaction in
the mentioned nuclei are measured and compared with the few existing data. The
spectra of several observables are discussed; indications of Quasi-Free
absorptions by a pair embedded in the nucleus can be obtained from
the study of the missing mass distributions.Comment: Version accepted by PR
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