1,026 research outputs found
Latent variable mixture modelling and individual treatment prediction
Understanding which groups of patients are more or less likely to benefit from specific treatments has important implications for healthcare. Many personalised medicine approaches in mental health employ variable-centred approaches to predicting treatment response, yet person-centred approaches that identify clinical profiles of patients can provide information on the likelihood of a range of important outcomes. In this paper, we discuss the use of latent variable mixture modelling and demonstrate its use in the application of a patient profiling algorithm using routinely collected patient data to predict outcomes from psychological treatments. This validation study analysed data from two services, which included nâŻ=âŻ44,905 patients entering treatment. There were different patterns of reliable recovery, improvement and clinical deterioration from therapy, across the eight profiles which were consistent over time. Outcomes varied between different types of therapy within the profiles: there were significantly higher odds of reliable recovery with High Intensity therapies in two profiles (32.5% of patients) and of reliable improvement in three profiles (32.2% of patients) compared with Low Intensity treatments. In three profiles (37.4% of patients) reliable recovery was significantly more likely if patients had CBT vs Counselling. The developments and potential application of latent variable mixture approaches are further discussed
Photodetachment study of He^- quartet resonances below the He(n=3) thresholds
The photodetachment cross section of He^- has been measured in the photon
energy range 2.9 eV to 3.3 eV in order to investigate doubly excited states.
Measurements were made channel specific by selectively detecting the residual
He atoms left in a particular excited state following detachment. Three
Feshbach resonances were found in the He(1s2p ^3P)+e^-(epsilon p) partial cross
section: a ^4S resonance below the He(1s3s ^3S) threshold and two ^4P
resonances below the He(1s3p ^3P) threshold. The measured energies of these
doubly excited states are 2.959260(6) eV, 3.072(7) eV and 3.26487(4) eV. The
corresponding widths are found to be 0.20(2) meV, 50(5) meV and 0.61(5) meV.
The measured energies agree well with recent theoretical predictions for the
1s3s4s ^4S, 1s3p^2 ^4P and 1s3p4p ^4P states, respectively, but the widths
deviate noticeably from calculations for 1s3p^2 ^4P and 1s3p4p ^4P states.Comment: 10 pages, 3 figures, LaTeX2e scrartcl, amsmath. Accepted by Journal
of Physics B; minor changes after referee repor
Elastic Cross Sections for Electron Collisions with Molecules Relevant to Plasma Processing
Absolute electron-impact cross sections for molecular targets, including their radicals, are important in developing plasma reactors and testing various plasma processing gases. Low-energy electron collision data for these gases are sparse and only the limited cross section data are available. In this report, elastic cross sections for electron-polyatomic molecule collisions are compiled and reviewed for 17molecules relevant to plasma processing. Elastic cross sections are essential for the absolute scale conversion of inelastic cross sections, as well as for testing computational methods. Data are collected and reviewed for elastic differential, integral, and momentum transfer cross sections and, for each molecule, the recommended values of the cross section are presented. The literature has been surveyed through early 2010.This work is accomplished as a collaboration through APAN (Asia-Pacific Atomic Data Network: a network for dissemination of collisional data relevant to plasmas, discharges, materials, and biosciences). H.C. acknowledges a support by the National Research Foundation of Korea (Grant No. 20100000035), and M.J.B. and S.J.B. support from the Australian Research Council Center of Excellence for Antimatter-Matter Studies. Collaboration between NIFS and NFRI is also acknowledged for the Korea-Japan exchanges
Trends in depression & anxiety symptom severity among mental health service attendees during the COVID-19 pandemic
Background: General population surveys have shown that some groups, particularly young women, experienced increased distress during nationally mandated restrictions to control the spread of COVID-19. However, there has been limited research on such trends among people with pre-existing mental health conditions, leaving mental health services ill equipped to plan for current and future lockdowns. /
Methods: Mean weekly scores on the GAD-7 and PHQ-9 between 01/01/2020-22/06/2020 (n=9,538 individuals) for all patients of two psychological treatment services (Improving Access to Psychological Therapies) in London, were compared to mean weekly scores from the same time periods in 2017-2019 (n=37,849). The proportion of scores which were above the clinical thresholds for âcasenessâ each week were compared, and scores between groups based on gender, age group, and ethnicity, were also compared. /
Results: Confirmed community transmission in the UK (26/02/2020-03/03/2020) and the announcement of the national âlockdownâ (23/03/2020) were associated with significant increases in anxiety symptom scores. âLockdownâ was associated with a decrease in depression scores. These changes were not maintained during lockdown. Significant increases in depression and anxiety were observed at week 23, as restrictions were eased. /
Limitations: This was an exploratory analysis in two services only. Residual confounding and selection biases cannot be ruled out. /
Conclusions: Differences in the weekly average symptom scores were short-term; they did not continue throughout âlockdownâ as might have been expected, except among older people. Replication of this study in other settings and investigating the potential benefits of more regular reviews or more intensive treatments for at-risk groups, are warranted
Absolute Electron Scattering Cross Sections for the CF2 Radical
Using a crossed electron-molecular beam experiment, featuring a skimmed nozzle beam with pyrolytic radical production, absolute elastic cross sections for electron scattering from the CF2 molecule have been measured. A new technique for placing measured cross sections on an absolute scale is used for molecular beams produced as skimmed supersonic jets. Absolute differential cross sections for CF2 are reported for incident electron energies of 30â50 eV and over an angular range of 20â135 deg. Integral cross sections are subsequently derived from those data. The present data are compared to new theoretical predictions for the differential and integral scattering cross sections, as calculated with the Schwinger multichannel variational method using the static-exchange and static-exchange plus polarization approximations
The effectiveness of adapted psychological interventions for people from ethnic minority groups: A systematic review and conceptual typology.
This review assessed the efficacy of adapted psychological interventions for Black and minority ethnic (BME) groups. A conceptual typology was developed based on adaptations reported in the literature, drawing on the common factors model, competence frameworks and distinctions between types of cultural adaptations. These distinctions were used to explore the efficacy of different adaptations in improving symptoms of a range of mental health problems for minority groups. Bibliographic searches of MEDLINE, Embase, PsycINFO, HMIC, ASSIA, CENTRAL, CDSR and CINAHL spanned the period from 1965 to December 2020. Adaptations to interventions were categorised: i) treatment specific: therapist-related, ii) treatment-specific: content-related and iii) organisation-specific. Meta-analyses of RCTs found a significant effect on symptom reduction when adapted interventions were compared to non-adapted active treatments (K = 30, Hedge's g = -0.43 [95% CI: -0.61, -0.25], p < .001). Studies often incorporated multiple adaptations, limiting the exploration of the comparative effectiveness of different adaptation types, although inclusion of organisation-specific adaptations may be associated with greater benefits. Future research, practitioner training and treatment and service development pertaining to adapted care for minority groups may benefit from adopting the conceptual typology described
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