6,826 research outputs found
Science is perception: what can our sense of smell tell us about ourselves and the world around us?
Human sensory processes are well understood: hearing, seeing, perhaps even tasting and touch—but we do not understand smell—the elusive sense. That is, for the others we know what stimuli causes what response, and why and how. These fundamental questions are not answered within the sphere of smell science; we do not know what it is about a molecule that … smells. I report, here, the status quo theories for olfaction, highlighting what we do not know, and explaining why dismissing the perception of the input as ‘too subjective’ acts as a roadblock not conducive to scientific inquiry. I outline the current and new theory that conjectures a mechanism for signal transduction based on quantum mechanical phenomena, dubbed the ‘swipe card’, which is perhaps controversial but feasible. I show that such lines of thinking may answer some questions, or at least pose the right questions. Most importantly, I draw links and comparisons as to how better understanding of how small (10’s of atoms) molecules can interact so specially with large (10 000’s of atoms) proteins in a way that is so integral to healthy living. Repercussions of this work are not just important in understanding a basic scientific tool used by us all, but often taken for granted, it is also a step closer to understanding generic mechanisms between drug and receptor, for example
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Interleukin 2 activation of natural killer cells rapidly induces the expression and phosphorylation of the Leu-23 activation antigen.
IL-2 potentiates both growth and cytotoxic function of T lymphocytes and NK cells. Resting peripheral blood NK cells can respond directly to rIL-2, without requirement for accessory cells or cofactors, and enhanced cytotoxicity can be measured within a few hours after exposure to this lymphokine. In this study, we describe an activation antigen, Leu-23, that is rapidly induced and phosphorylated after IL-2 stimulation of NK cells and a subset of low buoyant density T lymphocytes. Previously, it has been uncertain whether all NK cells or only a subset are responsive to IL-2. Since within 18 h after exposure to IL-2, essentially all NK cells express Leu-23, these findings indicate that all peripheral blood NK cells are responsive to stimulation by IL-2. The Leu-23 antigen is a disulfide-bonded homodimer, composed of 24-kD protein subunits with two N-linked oligosaccharides. Appearance of this glycoprotein on NK cells is IL-2 dependent and closely parallels IL-2-induced cytotoxicity against NK-resistant solid tumor cell targets
Desynchronization of pulse-coupled oscillators with delayed excitatory coupling
Collective behavior of pulse-coupled oscillators has been investigated
widely. As an example of pulse-coupled networks, fireflies display many kinds
of flashing patterns. Mirollo and Strogatz (1990) proposed a pulse-coupled
oscillator model to explain the synchronization of South East Asian fireflies
({\itshape Pteroptyx malaccae}). However, transmission delays were not
considered in their model. In fact, the presence of transmission delays can
lead to desychronization. In this paper, pulse-coupled oscillator networks with
delayed excitatory coupling are studied. Our main result is that under
reasonable assumptions, pulse-coupled oscillator networks with delayed
excitatory coupling can not achieve complete synchronization, which can explain
why another species of fireflies ({\itshape Photinus pyralis}) rarely
synchronizes flashing. Finally, two numerical simulations are given. In the
first simulation, we illustrate that even if all the initial phases are very
close to each other, there could still be big variations in the times to
process the pulses in the pipeline. It implies that asymptotical
synchronization typically also cannot be achieved. In the second simulation, we
exhibit a phenomenon of clustering synchronization
A handbook for rose growers
Although the current wave of popularity enjoyed by the rose began in the nineteenth century under the sponsorship of the Empress Josephine of France, the rose has been a cherished inhabitant of gardens since earliest times. In this respect it shares the esteem of gardeners with the lily and violet. However, unlike those flowers, its popularity has never waned. Its close association with mankind has led to its inclusion in the customs, languages and cultures of the peoples of the western world. In tribute to its beauty the Greeks gave it the title “Queen of Flowers”—a title which it well deserves if we are to credit the many attempts to grow it in the myriad climates and soils of the earth.
The genus Rosa is widely distributed over the north temperate zone. In a plant group whose members are adapted to the many different climates of this broad geographical area, it would be strange indeed if there were not at least one rose which would flourish in almost any given climatic condition.
Because the climate of Iowa and its neighboring states is rigorous and highly changeable, certain handicaps are presented to the rose grower living in this area. However, it is possible to select rose varieties that may be grown with a minimum of care in locations suitable for other sun-loving plants. The experienced gardener will carefully study the requirements of his particular situation before choosing the roses to grow in his garden
Superhydrophobic Thin Films Fabricated by Reactive Layer-by-Layer Assembly of Azlactone-Functionalized Polymers
We report an approach to the fabrication of superhydrophobic thin films that is based on the reactive layer-by-layer assembly of azlactone-containing polymer multilayers. We demonstrate that films fabricated from alternating layers of the azlactone functionalized polymer poly(2-vinyl- 4,4-dimethylazlactone) (PVDMA) and poly(ethyleneimine) (PEI) exhibit micro- and nanoscale surface features that result in water contact angles in excess of 150°. Our results reveal that the formation of these surface features is (i) dependent upon film thickness (i.e., the number of layers of PEI and PVDMA deposited) and (ii) that it is influenced strongly by the presence (or absence) of cyclic azlactone-functionalized oligomers that can form upon storage of the 2-vinyl-4,4-dimethylazlactone (VDMA) used to synthesize PVDMA. For example, films fabricated using polymers synthesized in the presence of these oligomers exhibited rough, textured surfaces and superhydrophobic behavior (i.e., advancing contact angles in excess of 150°). In contrast, films fabricated from PVDMA polymerized in the absence of this oligomer (e.g., using freshly distilled monomer) were smooth and only moderately hydrophobic (i.e., advancing contact angles of ̃75°). The addition of authentic, independently synthesized oligomer to samples of distilled VDMA at specified and controlled concentrations permitted reproducible fabrication of superhydrophobic thin films on the surfaces of a variety of different substrates. The surfaces of these films were demonstrated to be superhydrophobic immediately after fabrication, but they became hydrophilic after exposure to water for 6 days. Additional experiments demonstrated that it was possible to stabilize and prolong the superhydrophobic properties of these films (e.g., advancing contact angles in excess of 150° even after complete submersion in water for at least 6 weeks) by exploiting the reactivity of residual azlactones to functionalize the surfaces of the films using hydrophobic amines (e.g., aliphatic or semifluorinated aliphatic amines). Our results demonstrate a straightforward and substrate-independent approach to the design of superhydrophobic and reactive polymer-based coatings of potential use in a broad range of fundamental and applied contexts
Characterization of Knots and Links Arising From Site-specific Recombination on Twist Knots
We develop a model characterizing all possible knots and links arising from
recombination starting with a twist knot substrate, extending previous work of
Buck and Flapan. We show that all knot or link products fall into three
well-understood families of knots and links, and prove that given a positive
integer , the number of product knots and links with minimal crossing number
equal to grows proportionally to . In the (common) case of twist knot
substrates whose products have minimal crossing number one more than the
substrate, we prove that the types of products are tightly prescribed. Finally,
we give two simple examples to illustrate how this model can help determine
previously uncharacterized experimental data.Comment: 32 pages, 7 tables, 27 figures, revised: figures re-arranged, and
minor corrections. To appear in Journal of Physics
Information and Particle Physics
Information measures for relativistic quantum spinors are constructed to
satisfy various postulated properties such as normalisation invariance and
positivity. Those measures are then used to motivate generalised Lagrangians
meant to probe shorter distance physics within the maximum uncertainty
framework. The modified evolution equations that follow are necessarily
nonlinear and simultaneously violate Lorentz invariance, supporting previous
heuristic arguments linking quantum nonlinearity with Lorentz violation. The
nonlinear equations also break discrete symmetries. We discuss the implications
of our results for physics in the neutrino sector and cosmology
Folding model analysis of alpha radioactivity
Radioactive decay of nuclei via emission of particles has been
studied theoretically in the framework of a superasymmetric fission model using
the double folding (DF) procedure for obtaining the -nucleus
interaction potential. The DF nuclear potential has been obtained by folding in
the density distribution functions of the nucleus and the daughter
nucleus with a realistic effective interaction. The M3Y effective interaction
has been used for calculating the nuclear interaction potential which has been
supplemented by a zero-range pseudo-potential for exchange along with the
density dependence. The nuclear microscopic -nucleus potential thus
obtained has been used along with the Coulomb interaction potential to
calculate the action integral within the WKB approximation. This subsequently
yields microscopic calculations for the half lives of decays of
nuclei. The density dependence and the exchange effects have not been found to
be very significant. These calculations provide reasonable estimates for the
lifetimes of radioactivity of nuclei.Comment: 7 pages including 1 figur
Breaking Synchrony by Heterogeneity in Complex Networks
For networks of pulse-coupled oscillators with complex connectivity, we
demonstrate that in the presence of coupling heterogeneity precisely timed
periodic firing patterns replace the state of global synchrony that exists in
homogenous networks only. With increasing disorder, these patterns persist
until they reach a critical temporal extent that is of the order of the
interaction delay. For stronger disorder these patterns cease to exist and only
asynchronous, aperiodic states are observed. We derive self-consistency
equations to predict the precise temporal structure of a pattern from the
network heterogeneity. Moreover, we show how to design heterogenous coupling
architectures to create an arbitrary prescribed pattern.Comment: 4 pages, 3 figure
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