Electric Bike Product Conception and Styling According to Design Trends

The following case study portrays the several steps required to conceive a product from scratch. The first step involves an in-depth analysis of today’s electric bicycle market in order to obtain data and information relating to the levels of innovation and comfort required by customers. Then, we evaluate the implementation of a useful method to understand the level of innovation that the product must have to be competitive on the market. The second part studies the architecture of the product, considering the different components already sold on the market which will become part of the project. The third part concerns a comparison between different stylistic trends that the vehicle may have (in order to outline the best one). The fourth part concerns the CAD realization of the virtual model complete with all its parts, including a structural verification study of the frame. The last part studies the presentation of the product to the customer, exploring different effective ways to communicate what the strengths of the new product will be (also allowing them to customize it before its realization). The plan for the realization of the new product, starting from the concept to arrive at the final presentation to the customer, follows the methods proposed by applying a series of steps to develop a generic new product in an efficient, sensible, and methodical manner. Therefore, we will refer to quality function deployment (QFD), benchmarking (BM), design for X, until reaching the final prototyping and testing phases

On the use of shape memory alloys for deployable passive heat radiators in space satellites

The present work presents a multifunctional structure for space engineering application part of the TOPDESS project, funded by ESA. The main aim of the project is the design of a thermal control device able to deploy through passive actuation. A combined device has been designed, made up of a Pulsating Heat Pipe (PHP) foldable heat exchanger and Shape Memory Alloy (SMA) wire. The deployment of the SMA wire is conceived to be controlled by thermal contact with the heat source and by conduction along the wire. Since the heat sources are lumped and the wire is subject to convection, a temperature gradient develops along the wire. A monodimensional mode able to predict the behavior of an SMA wire subjected to a spatial temperature gradient, is presented in this paper. The results show that the system can carry out folding and unfolding cycles with rotation angles greater than 80° only if the wire is subjected to uniform temperature distribution; in the case of temperature gradient, the achievable rotation angle is about 20°. The analysis states the feasibility of the actuation system, highlighting the critical technological aspects, to lay the groundwork for the future development of the whole system

SARS-CoV-2 and companion animals: sources of information and communication campaign during the COVID-19 pandemic in Italy

This study analyzed data on the sources and the level of Italians’ awareness on the risk of infection by SARS-CoV-2 at the human–animal interface. Data were collected through a survey-type investigation on a representative sample of the Italian population. Forty-five percent of the interviewees were aware that companion animals could be infected by SARS-CoV-2. However, 29.8% were familiar with preventive measures to adopt to avoid viral transmission between infected humans and companion animals, and only 20.7% knew which companion animals could be at risk of infection. Higher awareness regarding the risk of SARS-CoV-2 transmission between animals and humans (51.7%) and the measures to prevent it (33.3%) was detected among companion animals’ owners. Notably, 40.4% of interviewees were not informed at all. Television broadcasts (26.4%) represented the main source of information, while only 3.5% of the interviewees relied on veterinarians, of which 31.9% considered this source of information as the most trustworthy. Overall, 72.4% of Italians recognized that the communication campaign on COVID-19 and companion animals was inadequate. This survey highlights the need for increasing the public awareness of the risk of companion animals being infected with SARS-CoV-2 and the involvement of professionals in the public communication on zoonoses. © 2023 by the authors

Age-Related Changes in Cardiac Autonomic Modulation and Heart Rate Variability in Mice

Objective: The aim of this study was to assess age-related changes in cardiac autonomic modulation and heart rate variability (HRV) and their association with spontaneous and pharmacologically induced vulnerability to cardiac arrhythmias, to verify the translational relevance of mouse models for further in-depth evaluation of the link between autonomic changes and increased arrhythmic risk with advancing age. Methods: Heart rate (HR) and time- and frequency-domain indexes of HRV were calculated from Electrocardiogram (ECG) recordings in two groups of conscious mice of different ages (4 and 19 months old) (i) during daily undisturbed conditions, (ii) following peripheral β-adrenergic (atenolol), muscarinic (methylscopolamine), and β-adrenergic + muscarinic blockades, and (iii) following β-adrenergic (isoprenaline) stimulation. Vulnerability to arrhythmias was evaluated during daily undisturbed conditions and following β-adrenergic stimulation. Results: HRV analysis and HR responses to autonomic blockades revealed that 19-month-old mice had a lower vagal modulation of cardiac function compared with 4-month-old mice. This age-related autonomic effect was not reflected in changes in HR, since intrinsic HR was lower in 19-month-old compared with 4-month-old mice. Both time- and frequency-domain HRV indexes were reduced following muscarinic, but not β-adrenergic blockade in younger mice, and to a lesser extent in older mice, suggesting that HRV is largely modulated by vagal tone in mice. Finally, 19-month-old mice showed a larger vulnerability to both spontaneous and isoprenaline-induced arrhythmias. Conclusion: The present study combines HRV analysis and selective pharmacological autonomic blockades to document an age-related impairment in cardiac vagal modulation in mice which is consistent with the human condition. Given their short life span, mice could be further exploited as an aged model for studying the trajectory of vagal decline with advancing age using HRV measures, and the mechanisms underlying its association with proarrhythmic remodeling of the senescent heart

Education in mine waste engineering: the experience of "SIGEO" Master's Course

On 19th July 1985 the failure of two tailings dams at the service of a fluorite mine in the Stava Valley (Italy) caused the death of 268 people and severe environmental and socioeconomic damage. Similar accidents have happened in Sgorigrad (Bulgaria, 1966), Aberfan (U.K., 1966), Buffalo Creek (USA, 1972), Aznalcollar (Spain, 1998), Taoshi (China, 2008) and many other places worldwide. The European Union has recognized the seriousness of the problems concerning the management and disposal of mining waste (over 400 million tonnes per year worldwide). With the 2006/21/CE Directive, the EU has urged all member States to carry out censuses, monitoring and consolidation of existing structures under the supervision of qualified experts. These experts should be provided with interdisciplinary knowledge that is difficult to attain during normal degree courses. For this reason, the Trento and Modena-Reggio Emilia Universities and the Turin Polytechnic have set up a post-graduate Master’s Course in “Analysis and Management of Geotechnical Structures”. The article describes the interdisciplinary approach adopted in the course and aims to stimulate the sharing of this initiative among other European Universities

Reply: An inverse association between tumour size and overdiagnosis may explain the results by Bucchi et al

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