Evaluation of bioprosthetic heart valve failure using a matrix-fibril shear stress transfer approach

A matrix-fibril shear stress transfer approach is devised and developed in this paper to analyse the primary biomechanical factors which initiate the structural degeneration of the bioprosthetic heart valves (BHVs). Using this approach, the critical length of the collagen fibrils l c and the interface shear acting on the fibrils in both BHV and natural aortic valve (AV) tissues under physiological loading conditions are calculated and presented. It is shown that the required critical fibril length to provide effective reinforcement to the natural AV and the BHV tissue is l c = 25.36 µm and l c = 66.81 µm, respectively. Furthermore, the magnitude of the required shear force acting on fibril interface to break a cross-linked fibril in the BHV tissue is shown to be 38 µN, while the required interfacial force to break the bonds between the fibril and the surrounding extracellular matrix is 31 µN. Direct correlations are underpinned between these values and the ultimate failure strength and the failure mode of the BHV tissue compared with the natural AV, and are verified against the existing experimental data. The analyses presented in this paper explain the role of fibril interface shear and critical length in regulating the biomechanics of the structural failure of the BHVs, for the first time. This insight facilitates further understanding into the underlying causes of the structural degeneration of the BHVs in vivo

Age-Related Changes in Cardiac Autonomic Modulation and Heart Rate Variability in Mice

Objective: The aim of this study was to assess age-related changes in cardiac autonomic modulation and heart rate variability (HRV) and their association with spontaneous and pharmacologically induced vulnerability to cardiac arrhythmias, to verify the translational relevance of mouse models for further in-depth evaluation of the link between autonomic changes and increased arrhythmic risk with advancing age. Methods: Heart rate (HR) and time- and frequency-domain indexes of HRV were calculated from Electrocardiogram (ECG) recordings in two groups of conscious mice of different ages (4 and 19 months old) (i) during daily undisturbed conditions, (ii) following peripheral β-adrenergic (atenolol), muscarinic (methylscopolamine), and β-adrenergic + muscarinic blockades, and (iii) following β-adrenergic (isoprenaline) stimulation. Vulnerability to arrhythmias was evaluated during daily undisturbed conditions and following β-adrenergic stimulation. Results: HRV analysis and HR responses to autonomic blockades revealed that 19-month-old mice had a lower vagal modulation of cardiac function compared with 4-month-old mice. This age-related autonomic effect was not reflected in changes in HR, since intrinsic HR was lower in 19-month-old compared with 4-month-old mice. Both time- and frequency-domain HRV indexes were reduced following muscarinic, but not β-adrenergic blockade in younger mice, and to a lesser extent in older mice, suggesting that HRV is largely modulated by vagal tone in mice. Finally, 19-month-old mice showed a larger vulnerability to both spontaneous and isoprenaline-induced arrhythmias. Conclusion: The present study combines HRV analysis and selective pharmacological autonomic blockades to document an age-related impairment in cardiac vagal modulation in mice which is consistent with the human condition. Given their short life span, mice could be further exploited as an aged model for studying the trajectory of vagal decline with advancing age using HRV measures, and the mechanisms underlying its association with proarrhythmic remodeling of the senescent heart

SARS-CoV-2 and companion animals: sources of information and communication campaign during the COVID-19 pandemic in Italy

This study analyzed data on the sources and the level of Italians’ awareness on the risk of infection by SARS-CoV-2 at the human–animal interface. Data were collected through a survey-type investigation on a representative sample of the Italian population. Forty-five percent of the interviewees were aware that companion animals could be infected by SARS-CoV-2. However, 29.8% were familiar with preventive measures to adopt to avoid viral transmission between infected humans and companion animals, and only 20.7% knew which companion animals could be at risk of infection. Higher awareness regarding the risk of SARS-CoV-2 transmission between animals and humans (51.7%) and the measures to prevent it (33.3%) was detected among companion animals’ owners. Notably, 40.4% of interviewees were not informed at all. Television broadcasts (26.4%) represented the main source of information, while only 3.5% of the interviewees relied on veterinarians, of which 31.9% considered this source of information as the most trustworthy. Overall, 72.4% of Italians recognized that the communication campaign on COVID-19 and companion animals was inadequate. This survey highlights the need for increasing the public awareness of the risk of companion animals being infected with SARS-CoV-2 and the involvement of professionals in the public communication on zoonoses. © 2023 by the authors

On the use of shape memory alloys for deployable passive heat radiators in space satellites

The present work presents a multifunctional structure for space engineering application part of the TOPDESS project, funded by ESA. The main aim of the project is the design of a thermal control device able to deploy through passive actuation. A combined device has been designed, made up of a Pulsating Heat Pipe (PHP) foldable heat exchanger and Shape Memory Alloy (SMA) wire. The deployment of the SMA wire is conceived to be controlled by thermal contact with the heat source and by conduction along the wire. Since the heat sources are lumped and the wire is subject to convection, a temperature gradient develops along the wire. A monodimensional mode able to predict the behavior of an SMA wire subjected to a spatial temperature gradient, is presented in this paper. The results show that the system can carry out folding and unfolding cycles with rotation angles greater than 80° only if the wire is subjected to uniform temperature distribution; in the case of temperature gradient, the achievable rotation angle is about 20°. The analysis states the feasibility of the actuation system, highlighting the critical technological aspects, to lay the groundwork for the future development of the whole system

On the handling performance of a vehicle with different front-to-rear wheel torque distributions

The handling characteristic is a classical topic of vehicle dynamics. Usually, vehicle handling is studied through the analysis of the understeer coe�cient in quasi-steady-state maneuvers. In this paper, experimental tests are performed on an electric vehicle with four independent mo- tors, which is able to reproduce front-wheel-drive, rear-wheel-drive and all-wheel-drive (FWD, RWD and AWD, respectively) architectures. The handling characteristics of each architecture are inferred through classical and new concepts. More speci�cally, the study presents a pro- cedure to compute the longitudinal and lateral tire forces, which is based on a �rst estimate and a subsequent correction of the tire forces that guarantee the equilibrium. A yaw moment analysis is then performed to identify the contributions of the longitudinal and lateral forces. The results show a good agreement between the classical and new formulations of the un- dersteer coe�cient, and allow to infer a relationship between the understeer coe�cient and the yaw moment analysis. The handling characteristics for the considered maneuvers vary with the vehicle speed and front-to-rear wheel torque distribution. In particular, an apparently surprising result arises at low speed, where the RWD architecture is the most understeering con�guration. This outcome is discussed through the yaw moment analysis, highlighting the yaw moment caused by the longitudinal forces of the front tires, which is signi�cant for high values of lateral acceleration and steering angle

Education in mine waste engineering: the experience of "SIGEO" Master's Course

On 19th July 1985 the failure of two tailings dams at the service of a fluorite mine in the Stava Valley (Italy) caused the death of 268 people and severe environmental and socioeconomic damage. Similar accidents have happened in Sgorigrad (Bulgaria, 1966), Aberfan (U.K., 1966), Buffalo Creek (USA, 1972), Aznalcollar (Spain, 1998), Taoshi (China, 2008) and many other places worldwide. The European Union has recognized the seriousness of the problems concerning the management and disposal of mining waste (over 400 million tonnes per year worldwide). With the 2006/21/CE Directive, the EU has urged all member States to carry out censuses, monitoring and consolidation of existing structures under the supervision of qualified experts. These experts should be provided with interdisciplinary knowledge that is difficult to attain during normal degree courses. For this reason, the Trento and Modena-Reggio Emilia Universities and the Turin Polytechnic have set up a post-graduate Master’s Course in “Analysis and Management of Geotechnical Structures”. The article describes the interdisciplinary approach adopted in the course and aims to stimulate the sharing of this initiative among other European Universities