Anterior gradient 2 and 3 – two prototype androgen‐responsive genes transcriptionally upregulated by androgens and by oestrogens in prostate cancer cells

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/96748/1/febs12118.pd

Effects of chitosan treatment on strength and thickening properties of oil well cement

The research objectives were to investigate the influence of chitosan on strength and thickening properties of oil well cement under the downhole temperature condition. The results showed that the chitosan has the ability to increase the thickening time, but due to chelating Ca2+ ion, it may cause consistency wave at initial stage, and shorten thickening time at higher dosage and higher temperature. Chelating pretreatment will weaken the retarding effect of chitosan. Effects of LMW chitosan on strength and thickening properties are more acute than that of HMW chitosan. Because of increasing induction period, the pre-chelating LMW chitosan extends thickening time

progression in Swedish

and NF-κBIα genes in melanoma risk, clinicopathological features and tumo

The application of coated superabsorbent polymer in well cement for plugging the microcrack

The research objectives are designed to realize the application of superabsorbent polymer (SAP) in well cement to plug microcrack. Gypsum-chitosan-gypsum coated SAP is proposed. Percolation theory is used to research plugging microcrack mechanism. According to the exact analytical solution of square plane percolation threshold, dosage threshold of coated SAP microspheres is calculated as 28.40%, which can deliver the plugging of microcrack. The method of manufacturing quantitative microcrack is established, and self-designed instrument is employed to test plugging performance. The results show the ability of plugging microcrack when the dosage of coated SAP microsphere is higher than the threshold

Low elastic modulus and expansive well cement system: The application of gypsum microsphere

The research objectives in this paper are designed to use gypsummicrosphere to achieve low elastic modulus and expansive well cement system. Results show that gypsum microsphere has the ability to compensate for volume shrinkage of hardened cement. Expansive crystals produced by the reaction of tricalcium aluminate and dihydrate gypsum exist around gypsum microsphere. Though compressive strength of hardened cement is improved by gypsum powder, existence of massive crystals increases brittleness of cement sheath. Compared with gypsum powder, due to porous structure, gypsum microsphere decreases elastic modulus of hardened cement, which shows brilliant resistance to stress and strain

Importance of polymorphisms at NF-κB1 and NF-κBIα genes in melanoma risk, clinicopathological features and tumor progression in Swedish melanoma patients

In this study, functional polymorphisms of NF-κB1 and NF-κBIα genes were examined in 185 melanoma patients and 438 tumor-free individuals. Associations of the polymorphisms with melanoma risk, age and pigment phenotypes of the patients and clinico-pathological tumor characteristics were analyzed. DNAs were isolated from mononuclear cells of venous blood. Polymorphisms of the genes were genotyped by a PCR-RFLP technique, and transcription level of NF-κBIα was examined by a quantitative real-time reverse transcription PCR. Results showed that both ATTG insertion polymorphism of NF-κB1 and A to G polymorphism of NF-κBIα genes were correlated with melanoma risk, especially, in a combination of ATTG2/ATTGT2 and GG. NF-κB1 ATTG2/ATTG2 and NF-κBIα GG genotypes were associated with male gender and age > 65 years (at diagnosis). Patients with ATTG1/ATTG1 genotype had thinner tumors and lower Clark levels at diagnosis. Frequency of ATTG1/ATTG1 genotype was higher in patients with melanomas on intermittently sun-exposed pattern of the body and NF-κBIα GG was more frequent in the patients with melanomas at rarely exposed sites. There were no differences in the gene transcription level between patients with different NF-κBIα genotypes. These data suggest that NF-κB1 and NF-κBIα genes might be susceptible genes for melanoma risk and functional polymorphisms of these genes might be biological predictors for melanoma progression.The original publication is available at www.springerlink.com: Huajie Bu, Inger Rosdahl, XiaoFeng Sun, Katarina Holmdahl-Källenand and Hong Zhang, Importance of polymorphisms at NF-κB1 and NF-κBIα genes in melanoma risk, clinicopathological features and tumor progression in Swedish melanoma patients, 2007, Journal of Cancer Research and Clinical Oncology, (133), 11, 859-866. http://dx.doi.org/10.1007/s00432-007-0228-7 . Copyright: Springer-Verlag, www.springerlink.co