Antibacterial Bioactive Glass, S53P4, for Chronic Bone Infections - A Multinational Study

Correction: Volume: 971 Pages: 115-116 DOI: 10.1007/5584_2017_13 Published: 2017 WOS:000446017300010Osteomyelitis is an infectious process in bone that occasionally leads to bone destruction. Traditionally, the surgical treatment procedure is performed in combination with systemic and local antibiotics as a two-stage procedure that uses autograft or allograft bone for filling of the cavitary defect. Bioactive glass (BAG-S53P4) is a bone substitute with proven antibacterial and bone bonding properties. One hundred and sixteen patients who had verified chronic osteomyelitis was treated using BAG-S53P4 as part of the treatment. Most of the patients had previously undergone numerous procedures, sometimes for decades. A register of patient data obtained from 11 centers from Finland, Italy, the Netherlands, Germany, Azerbaijan and Poland was set-up and continuously maintained at Helsinki University Central Hospital. The location of the osteomyelitis was mainly in the tibia followed by the femur and then the calcaneus. The median age of the patients was 48 years (15-87). The patients were either treated according to a one-stage procedure without local antibiotics (85 %) or by a two-stage procedure using antibiotic beads in the first procedure (15 %). The minimum follow-up was 1 year (12-95 months, median 31). The cure rate was 104/116, the total success rate 90 % and most of the patients showed a rapid recovery. The study shows that (BAG-S53P4) can be used in a one-stage procedure in treatment of osteomyelitis with excellent results.Peer reviewe

Preparation ofpatients for hip or knee replacement surgery asan important element inpreventing periprosthetic joint infection

Replacement of large joints in the lower limbs is a commonly accepted and used method for the treatment of osteoarthritis. Like any other intervention, this treatment method also involves the risk of complications. Periprosthetic joint infection is one of the most serious ones. It qualifies patients for further procedures, which significantly impairs their daily activity and the comfort of life. Osteoarticular infections represent a major therapeutic challenge. This is associated with both, poor penetration of antibiotics into the osteoarticular compartment (system) as well as with the increasing drug resistance of pathogens. Osteoarticular infections require several weeks of antibiotic therapy, as an adjunct treatment, which is an additional financial burden. The implementation of primary prevention scheme in periprosthetic joint infection allows for a significant reduction in the risk of this complication. The article discusses the different nature of the infection within joints and orthopaedic implants. We have presented the key principles for the prevention of septic complications associated with total hip and knee replacement, by discussing the most common sources of primary infection. We have proposed a treatment algorithm based on diagnostic tests reducing the risk of infectious complications and increasing the safety of surgical intervention (surgical procedure) as well as the chances for good long-term treatment outcomes

Complicated thromboembolic prophylaxis in the treatment of septic gonitis – case report

In this paper the case of a patient subjected to orthopaedic treatment with a history of a number of internal comorbidities, cardiac ones in particular, has been reported. Cardiac comorbidities were related to the implantation of a VVI pacemaker. The patient was chronically administered acenocoumarol with a standard INR control. He developed infectious arthritis of the left knee joint. The  condition was the indication for surgery. The  surgical treatment was performed with the implementation of antithrombotic prophylaxis using low-molecular-weight heparin at a dose as prescribed by a cardiologist. The prescribed dosage of nadroparin – 100 mg – was higher than indicated in both Polish and international regimen standards. Higher dose was also maintained in next days that followed the surgery. Intra-articular haematoma occurred as a post-surgery complication, hence the revision of the knee joint was performed. The haematoma was diagnosed intraoperatively, then removed and pulsed lavage was performed. Garamycin sponge was applied to treat the inflammation. A targeted antibiotic therapy was continued. Surgical site drainage was performed for one day without the use of negative pressure. Thromboembolic prophylaxis was implemented in accordance with the applicable dosage regimen in Poland. In view of a vast majority of thrombosis risk factors, prolonged prophylaxis with heparin and return to acenocoumarol were indicated once the surgical would had healed. As a result, other early and late postoperative complications were avoided