Controlling Grain Size in Cold Worked and Annealed 1100 Aluminum to Optimize Ductility in Rocket Diaphragm Systems

Liquid propellant rocket diaphragms require extreme ductility. 1100 Aluminum is used for its high ductility, but the post-processing cold work and subsequent anneal result in excessively large grains. The effect of heat treatment and cold work on grain size in 1100 aluminum was explored. The samples were cold worked to 0, 5, 10, 15 and 30% using tensile elongation. The samples were then heat treated per AMS 2770 with either a Steel Conduction (1000 – 1150°F/min) or a Production (16 – 18°F/min) heating rate. The grain size of the samples were measured using the mean lineal intercept method. The grain diameter ranged from 81 – 189 μm for the Production rate and 83 – 209 μm for the Steel Conduction rate. The 15% cold worked Production rate samples were found to have significantly larger grains than those of the smaller cold work amounts as well as the 15% cold worked Steel Conduction rate samples. This indicated an interaction between the 15% cold work amount and the Production heat treatment which allowed for significant grain growth. The 30% cold worked samples were found to have grain growth in both heat treatments with the largest average grain diameters. The results indicate that the longer times at elevated temperatures during the Production heat treatment allow for significant grain growth at lower cold work amounts. In addition, grain growth is unavoidable for 30% cold work regardless of heating rate

Le point de vue des patients sur le degré de participation des résidents en salle d’opération dans le cas d’une arthroplastie totale de la hanche ou du genou

Introduction: Previous work suggests that patients do not understand the extent of trainee involvement in their care and are uncomfortable with trainee involvement. Methods: We recruited 202 English speaking patients with previous or planned total joint arthroplasty of the lower limb for a prospective survey trial. We assessed participant’s knowledge of trainee level of education and confidence of trainee involvement in their surgery as a function of supervision. Results: Participants’ mean level of confidence in the consultant surgeon was 4.30 (SD±1.13) on a 5-point Likert scale. Confidence in residents was significantly less, regardless of resident experience (p < 0.05). 11.1% of participants did not want trainees involved in their treatment.  60.6% would like to know more about the education level of the trainee. Less than half of participants correctly identified the education level of residents and fellows. Conclusion: Patient confidence in trainees performing part or all of their surgery increases with resident experience and supervision. Most patients do not understand the hierarchy in education of medical trainees and would like to know more about the education level of the trainee involved in their care. Further work should explore how we can help patients better understand trainee involvement in their surgical care.Contexte: Des travaux antérieurs suggèrent que les patients ne comprennent pas le degré de participation des stagiaires dans leurs soins et que cette participation les rend mal à l’aise. Méthodes : Nous avons recruté 202 patients anglophones qui ont eu ou qui vont avoir une arthroplastie totale du membre inférieur pour un essai prospectif par sondage. Nous avons évalué les connaissances des participants sur le niveau de formation des résidents et leur confiance dans la participation des stagiaires dans l’intervention en fonction de la supervision dont ils font l’objet. Résultats : Le niveau moyen de confiance des participants dans le chirurgien consultant était de 4,30 (SD±1,13) sur une échelle de Likert à 5 points. Le degré de confiance dans les résidents était bien inférieur, quelle que soit l’expérience du résident (p < 0,05). Parmi les participants, 11,1 % ne voulaient pas que les résidents interviennent dans leur traitement et 60,6 % souhaitaient en savoir plus sur leur niveau de formation. Moins de la moitié des participants ont correctement identifié le niveau de formation des résidents et des fellows. Conclusion : La confiance des patients par rapport au fait que les stagiaires effectuent une partie ou la totalité de l’intervention chirurgicale augmente avec l’expérience et la supervision des résidents. La plupart des patients ne comprennent pas les niveaux de formation des stagiaires en médecine et voudraient en savoir plus sur celui du médecin en formation qui intervient dans leurs soins. Des études plus poussées s’imposent sur la manière d’aider les patients à mieux comprendre la participation des stagiaires dans les soins chirurgicaux

Polyglutamine-expanded androgen receptor interferes with TFEB to elicit autophagy defects in SBMA.

Macroautophagy (hereafter autophagy) is a key pathway in neurodegeneration. Despite protective actions, autophagy may contribute to neuron demise when dysregulated. Here we consider X-linked spinal and bulbar muscular atrophy (SBMA), a repeat disorder caused by polyglutamine-expanded androgen receptor (polyQ-AR). We found that polyQ-AR reduced long-term protein turnover and impaired autophagic flux in motor neuron-like cells. Ultrastructural analysis of SBMA mice revealed a block in autophagy pathway progression. We examined the transcriptional regulation of autophagy and observed a functionally significant physical interaction between transcription factor EB (TFEB) and AR. Normal AR promoted, but polyQ-AR interfered with, TFEB transactivation. To evaluate physiological relevance, we reprogrammed patient fibroblasts to induced pluripotent stem cells and then to neuronal precursor cells (NPCs). We compared multiple SBMA NPC lines and documented the metabolic and autophagic flux defects that could be rescued by TFEB. Our results indicate that polyQ-AR diminishes TFEB function to impair autophagy and promote SBMA pathogenesis

The prevalence of potentially modifiable functional deficits and the subsequent use of occupational and physical therapy by older adults with cancer

Occupational and physical therapy (OT/PT) services seek to reduce morbidity, mortality, and improve the quality of life of individuals; however, little is known about the needs and use of OT/PT for older adults with cancer. The goal of this study was to describe the functional deficits and their associations with other factors, and to examine the use of OT/PT after a noted functional deficit

Springfield\u27s Legacy: A Vision for A Transformative Transit-Oriented Union Station District

This urban design studio developed concepts around equitable transportation Union Station in Springfield, Massachusetts. The work creates a vision for the Union Station District, a revitalized mixed-use walkable neighborhood adjacent to the restored transportation center. It emphasizes reusing the city’s historic street grid in new, forward thinking ways that enhance neighborhood connectivity. The plan creates physical and social networks that bring together diverse groups of residents and visitors. The Union Station District will be a place that offers a range of non-automobile transportation options to residents and visitors and will help transforming an area characterized by vacant lots and empty buildings into a vibrant, well-connected TOD neighborhood. The Union Station District is envisioned as an active, vibrant place that is accessible and inviting to all. KEY GOAL AND MISSION OF THE PROJECT: • Creating a vibrant, connected, equitable neighborhood that reflects Springfield’s diversity KEY DESIGN AND PLANNING OBJECTIVES AND OUTCOMES: Creating places that welcome people of color and traditionally underrepresented communities Promoting public health and community well-being Encouraging bicycling, walking, public transportation and micro-mobility options for all ages including the youth Fostering arts/culture and innovation economy for placemaking/economic development Creating connectivity and mobility for persons with disabilities Provide better connectivity, reusing the existing street grid, and historic infrastructure Include strategies that limit impervious surfaces/stormwater to improve local climat

AK002, a Humanized Sialic Acid-Binding Immunoglobulin-Like Lectin-8 Antibody that Induces Antibody-Dependent Cell-Mediated Cytotoxicity against Human Eosinophils and Inhibits Mast Cell-Mediated Anaphylaxis in Mice.

INTRODUCTION: Pathologic accumulation and activation of mast cells and eosinophils are implicated in allergic and inflammatory diseases. Sialic acid-binding immunoglobulin-like lectin (Siglec)-8 is an inhibitory receptor selectively expressed on mast cells, eosinophils and, at a lower extent, basophils. When engaged with an antibody, Siglec-8 can induce apoptosis of activated eosinophils and inhibit mast cell activation. AK002 is a humanized, non-fucosylated IgG1 anti-Siglec-8 antibody undergoing clinical investigation for treatment of allergic, inflammatory, and proliferative diseases. Here we examine the human tissue selectivity of AK002 and evaluate the in vitro, ex vivo, and in vivo activity of AK002 on eosinophils and mast cells. METHODS: The affinity of AK002 for Siglec-8 and CD16 was determined by biolayer interferometry. Ex vivo activity of AK002 on human eosinophils from blood and dissociated human tissue was tested in apoptosis and antibody-dependent cell-mediated cytotoxicity (ADCC) assays. The in vivo activity of a murine precursor of AK002 (mAK002) was tested in a passive systemic anaphylaxis (PSA) humanized mouse model. RESULTS: AK002 bound selectively to mast cells, eosinophils and, at a lower level, to basophils in human blood and tissue and not to other cell types examined. AK002 induced apoptosis of interleukin-5-activated blood eosinophils and demonstrated potent ADCC activity against blood eosinophils in the presence of natural killer cells. AK002 also significantly reduced eosinophils in dissociated human lung tissue. Furthermore, mAK002 prevented PSA in humanized mice through mast cell inhibition. CONCLUSION: AK002 selectively evokes potent apoptotic and ADCC activity against eosinophils and prevents systemic anaphylaxis through mast cell inhibition

AK002, a Humanized Sialic Acid-Binding Immunoglobulin-Like Lectin-8 Antibody that Induces Antibody-Dependent Cell-Mediated Cytotoxicity against Human Eosinophils and Inhibits Mast Cell-Mediated Anaphylaxis in Mice

INTRODUCTION: Pathologic accumulation and activation of mast cells and eosinophils are implicated in allergic and inflammatory diseases. Sialic acid-binding immunoglobulin-like lectin (Siglec)-8 is an inhibitory receptor selectively expressed on mast cells, eosinophils and, at a lower extent, basophils. When engaged with an antibody, Siglec-8 can induce apoptosis of activated eosinophils and inhibit mast cell activation. AK002 is a humanized, non-fucosylated IgG1 anti-Siglec-8 antibody undergoing clinical investigation for treatment of allergic, inflammatory, and proliferative diseases. Here we examine the human tissue selectivity of AK002 and evaluate the in vitro, ex vivo, and in vivo activity of AK002 on eosinophils and mast cells. METHODS: The affinity of AK002 for Siglec-8 and CD16 was determined by biolayer interferometry. Ex vivo activity of AK002 on human eosinophils from blood and dissociated human tissue was tested in apoptosis and antibody-dependent cell-mediated cytotoxicity (ADCC) assays. The in vivo activity of a murine precursor of AK002 (mAK002) was tested in a passive systemic anaphylaxis (PSA) humanized mouse model. RESULTS: AK002 bound selectively to mast cells, eosinophils and, at a lower level, to basophils in human blood and tissue and not to other cell types examined. AK002 induced apoptosis of interleukin-5-activated blood eosinophils and demonstrated potent ADCC activity against blood eosinophils in the presence of natural killer cells. AK002 also significantly reduced eosinophils in dissociated human lung tissue. Furthermore, mAK002 prevented PSA in humanized mice through mast cell inhibition. CONCLUSION: AK002 selectively evokes potent apoptotic and ADCC activity against eosinophils and prevents systemic anaphylaxis through mast cell inhibition

Quality of Life Changes during the Pre- to Post-Diagnosis Period and Treatment-Related Recovery Time in Older Women with Breast Cancer

Healthcare providers have little population-based evidence about health-related quality of life (HRQOL) changes, from the pre- to post-diagnosis period, and treatment-related recovery time for women ages 65 and older diagnosed with breast cancer

Barriers to managing childhood mental health problems: a systematic review of primary care practitioner's perceptions

Background: Mental health problems are common and typically have an early onset. Effective treatments for mental health problems in childhood and adolescence are available yet only a minority of affected children access them. This is of serious concern, considering the far-reaching and long-term negative consequences of such problems. Primary care is usually the first port of call for concerned parents so it is important to understand how primary care practitioners (PCPs) manage childhood mental health problems and the barriers they face. Aim: To ascertain PCP’s perceptions of barriers preventing effective management of childhood mental health problems Design: A systematic review of qualitative and quantitative literature Method: A database search of peer-reviewed articles using PsycInfo, MEDLINE, EMBASE and Web of Science, until October 2014, was conducted. Additional studies were identified through hand-searching and forward-citation searches. Studies needed to have at least one search term in four categories: (i) primary care, (ii) childhood/adolescence, (iii) mental health and (iv) barriers. Results: A total of 4151 articles were found, of which 43 were included (30 quantitative and 13 qualitative). The majority of the barriers related to identification, management and/or referral. Considerable barriers included a lack of providers and resources, extensive waiting lists and financial restrictions. Conclusion: The identification of a broad range of significant barriers highlights the need to strengthen the ability to deal with these common difficulties in primary care. There is a particular need for tools and training to aid accurate identification and management, and for more efficient access to specialist services