Function-based Intersubject Alignment of Human Cortical Anatomy

Making conclusions about the functional neuroanatomical organization of the human brain requires methods for relating the functional anatomy of an individual's brain to population variability. We have developed a method for aligning the functional neuroanatomy of individual brains based on the patterns of neural activity that are elicited by viewing a movie. Instead of basing alignment on functionally defined areas, whose location is defined as the center of mass or the local maximum response, the alignment is based on patterns of response as they are distributed spatially both within and across cortical areas. The method is implemented in the two-dimensional manifold of an inflated, spherical cortical surface. The method, although developed using movie data, generalizes successfully to data obtained with another cognitive activation paradigm—viewing static images of objects and faces—and improves group statistics in that experiment as measured by a standard general linear model (GLM) analysis

System for sterilizing objects

A system for producing a stream of humidified sterilizing gas for sterilizing objects such as the water systems of space vehicles and the like includes a source of sterilant gas which is fed to a mixing chamber which has inlet and outlet ports. The level of the water only partially fills the mixing chamber so as to provide an empty space adjacent the top of the chamber. A heater is provided for heating the water in the chamber so as to produce a humidified atmosphere. The sterilant gas is fed through an arcuate shaped tubular member connected to the inlet port of the mixing chamber for producing a vortex type of flow of sterilant gas into the chamber for humidification. A tubular member extends from the mixing chamber for supplying the humidified sterilant gas to the object for being sterilized. Scrubbers are provided for removing the sterilant gas after use

Nanomechanical morphology of amorphous, transition, and crystalline domains in phase change memory thin films

In the search for phase change materials (PCM) that may rival traditional random access memory, a complete understanding of the amorphous to crystalline phase transition is required. For the well-known Ge2Sb2Te5 (GST) and GeTe (GT) chalcogenides, which display nucleation and growth dominated crystallization kinetics, respectively, this work explores the nanomechanical morphology of amorphous and crystalline phases in 50 nm thin films. Subjecting these PCM specimens to a lateral thermal gradient spanning the crystallization temperature allows for a detailed morphological investigation. Surface and depth-dependent analyses of the resulting amorphous, transition and crystalline regions are achieved with shallow angle cross-sections, uniquely implemented with beam exit Ar ion polishing. To resolve the distinct phases, ultrasonic force microscopy (UFM) with simultaneous topography is implemented revealing a relative stiffness contrast between the amorphous and crystalline phases of 14% for the free film surface and 20% for the cross-sectioned surface. Nucleation is observed to occur preferentially at the PCM-substrate and free film interface for both GST and GT, while fine subsurface structures are found to be sputtering direction dependent. Combining surface and cross-section nanomechanical mapping in this manner allows 3D analysis of microstructure and defects with nanoscale lateral and depth resolution, applicable to a wide range of materials characterization studies where the detection of subtle variations in elastic modulus or stiffness are required

Alternate Stimuli for the Elicitation of Event-Related Potentials

Brain-Computer Interfaces (BCIs) are systems that leverage user-brain activity to identify and perform specific functions. In applications requiring overt visual attention, focusing on visual stimuli with known temporal variation can elicit measurable changes in brain activity. However, elements of BCI applications can be intrusive. This research was designed to determine if Event-Related Potentials (ERPs), to include Steady-State Visually-Evoked Potentials (SSVEPs), could be elicited and interpreted from less obtrusive stimuli. Specifically, this research explores the use of variable frequency and long-wavelength (infrared) stimuli for SSVEP interpretation to explore the application of less obtrusive stimuli for application in BCIs. It was determined that increasing the primary wavelength of visual stimuli into the near infrared portion of the electromagnetic spectrum negatively impacts the observation of ERPs in human subjects. Additionally, the longer primary wavelengths of visual stimuli have a negative impact on the observation of target frequency band powers in SSVEP experiments. However, each of these signals were detected across the majority of participants for Light-Emitting Diodes (LEDs) with center frequencies as high as 770 nm and across some participants and conditions for LEDs with center frequencies as high as 830 nm